Abstract:
:The primary objective of this review is to develop a conceptual model for Crohn's disease (CD) outlining the disease burden for patients, healthcare systems and wider society, as reported in the scientific literature. A search was conducted using MEDLINE, PsycINFO, EconLit, Health Economic Evaluation Database and Centre for Reviews and Dissemination databases. Patient-reported outcome (PRO) measures widely used in CD were reviewed according to the US FDA PRO Guidance for Industry. The resulting conceptual model highlights the characterization of CD by gastrointestinal disturbances, extra-intestinal and systemic symptoms. These symptoms impact physical functioning, ability to complete daily activities, emotional wellbeing, social functioning, sexual functioning and ability to work. Gaps in conceptual coverage and evidence of reliability and validity for some PRO measures were noted. Review findings also highlight the substantial direct and indirect costs associated with CD. Evidence from the literature confirms the substantial burden of CD to patients and wider society; however, future research is still needed to further understand burden from the perspective of patients and to accurately understand the economic burden of disease. Challenges with existing PRO measures also suggest the need for future research to refine or develop new measures.
journal_name
Expert Rev Pharmacoecon Outcomes Resjournal_title
Expert review of pharmacoeconomics & outcomes researchauthors
Gater A,Kitchen H,Heron L,Pollard C,Håkan-Bloch J,Højbjerre L,Hansen BB,Strandberg-Larsen Mdoi
10.1586/14737167.2015.1045883subject
Has Abstractpub_date
2015-01-01 00:00:00pages
643-56issue
4eissn
1473-7167issn
1744-8379journal_volume
15pub_type
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
doi:10.1586/14737167.4.5.573
更新日期:2004-10-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
doi:10.1586/14737167.5.1.59
更新日期:2005-02-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章
doi:10.1586/14737167.6.1.67
更新日期:2006-02-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章,评审
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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更新日期:2008-10-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章,评审
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journal_title:Expert review of pharmacoeconomics & outcomes research
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更新日期:2010-04-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
pub_type: 杂志文章,评审
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journal_title:Expert review of pharmacoeconomics & outcomes research
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更新日期:2012-04-01 00:00:00
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journal_title:Expert review of pharmacoeconomics & outcomes research
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journal_title:Expert review of pharmacoeconomics & outcomes research
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更新日期:2003-08-01 00:00:00
abstract::The past 10 years has witnessed a major transformation in the treatment of rheumatoid arthritis, a chronic condition that leads to significant morbidity, impairment in quality of life and mortality. Adalimumab joins a class of biologic response modifiers that prevent joint destruction and maintain functional status. F...
journal_title:Expert review of pharmacoeconomics & outcomes research
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