Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.

abstract：:Almost 150 years after the first identification of Neandertal skeletal material, the cognitive and symbolic abilities of these populations remain a subject of intense debate. We present 99 new Neandertal remains from the Troisième caverne of Goyet (Belgium) dated to 40,500-45,500 calBP. The remains were identified thr...

journal_title：Scientific reports

authors： Rougier H,Crevecoeur I,Beauval C,Posth C,Flas D,Wißing C,Furtwängler A,Germonpré M,Gómez-Olivencia A,Semal P,van der Plicht J,Bocherens H,Krause J

更新日期：2016-07-06 00:00:00

abstract：:Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodime...

journal_title：Scientific reports

authors： Kawasaki Y,Sakimura A,Park CM,Tomaru R,Tanaka T,Ozawa T,Zhou Y,Narita K,Kishi H,Muraguchi A,Sakurai H

更新日期：2016-08-17 00:00:00

abstract：:15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the stru...

journal_title：Scientific reports

authors： Kim SN,Akindehin S,Kwon HJ,Son YH,Saha A,Jung YS,Seong JK,Lim KM,Sung JH,Maddipati KR,Lee YH

更新日期：2018-06-11 00:00:00

abstract：:The temporal dynamics of brain activation during visual and auditory perception of congruent vs. incongruent musical video clips was investigated in 12 musicians from the Milan Conservatory of music and 12 controls. 368 videos of a clarinetist and a violinist playing the same score with their instruments were presente...

journal_title：Scientific reports

authors： Proverbio AM,Calbi M,Manfredi M,Zani A

更新日期：2014-07-29 00:00:00

abstract：:Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a lack of understanding of the mechanisms behind the disease, and consequently a lack of druggable targets. PAK4 plays critical roles in cell s...

journal_title：Scientific reports

authors： Rane C,Senapedis W,Baloglu E,Landesman Y,Crochiere M,Das-Gupta S,Minden A

更新日期：2017-02-15 00:00:00

abstract：:Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...

journal_title：Scientific reports

authors： Liu F,Li H,Ren C,Bo X,Shu W

更新日期：2016-06-22 00:00:00

abstract：:The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama G...

journal_title：Scientific reports

authors： Bowyer FT,Shore AJ,Wood RA,Alcott LJ,Thomas AL,Butler IB,Curtis A,Hainanan S,Curtis-Walcott S,Penny AM,Poulton SW

更新日期：2020-02-10 00:00:00

abstract：:Intracellular endogenous fluorescent co-enzymes, reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), play a pivotal role in cellular metabolism; quantitative assessment of their presence in living cells can be exploited to monitor cellular energetics in Parkinson's disease (PD), a n...

journal_title：Scientific reports

authors： Chakraborty S,Nian FS,Tsai JW,Karmenyan A,Chiou A

更新日期：2016-01-13 00:00:00

abstract：:Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and the depletion of the glutathione (GSx) stores in neural tissue. The use of N-acetylcysteine (NAC) has been recently p...

journal_title：Scientific reports

authors： Faria M,Prats E,Gómez-Canela C,Hsu CY,Arick MA 2nd,Bedrossiantz J,Orozco M,Garcia-Reyero N,Ziv T,Ben-Lulu S,Admon A,Gómez-Oliván LM,Raldúa D

更新日期：2019-11-11 00:00:00

abstract：:We investigated high-efficiency two-terminal tandem photovoltaic (PV) devices consisting of a p/i/n thin film silicon top sub-cell (p/i/n-TFS) and a heterojunction with an intrinsic thin-layer (HIT) bottom sub-cell. We used computer simulations and experimentation. The short-circuit current density (Jsc) of the top su...

journal_title：Scientific reports

authors： Park J,Dao VA,Kim S,Pham DP,Kim S,Le AHT,Kang J,Yi J

更新日期：2018-10-18 00:00:00

abstract：:Chondrichthyes - sharks, rays, skates, and chimeras, are among the most threatened and data deficient vertebrate species. Global demand for shark and ray derived products, drives unregulated and exploitative fishing practices, which are in turn facilitated by the lack of ecological data required for effective conserva...

journal_title：Scientific reports

authors： Johri S,Solanki J,Cantu VA,Fellows SR,Edwards RA,Moreno I,Vyas A,Dinsdale EA

更新日期：2019-03-14 00:00:00

abstract：:Various important topological properties of healthy brain connectome have recently been identified. However, the manner in which brain lesion changes the functional network topology is unknown. We examined how critical specific brain areas are in the maintenance of network topology using multivariate support vector re...

journal_title：Scientific reports

authors： Yuan B,Fang Y,Han Z,Song L,He Y,Bi Y

更新日期：2017-12-20 00:00:00

abstract：:Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of ...

journal_title：Scientific reports

authors： Hirabayashi K,Nakazawa Y,Sakashita K,Kurata T,Saito S,Yoshikawa K,Tanaka M,Yanagisawa R,Koike K

更新日期：2014-11-06 00:00:00

abstract：:The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple rou...

journal_title：Scientific reports

authors： Pal I,Bhattacharyya D,Kar RK,Zarena D,Bhunia A,Atreya HS

更新日期：2019-03-14 00:00:00

abstract：:A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...

journal_title：Scientific reports

authors： Haloul M,Oliveira ERA,Kader M,Wells JZ,Tominello TR,El Andaloussi A,Yates CC,Ismail N

更新日期：2019-10-01 00:00:00

abstract：:The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell sur...

journal_title：Scientific reports

authors： Bastida-Ruiz D,Wuillemin C,Pederencino A,Yaron M,Martinez de Tejada B,Pizzo SV,Cohen M

更新日期：2020-06-15 00:00:00

abstract：:Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous factors. So far, root exudates have mainly been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated for polar and semi-pol...

journal_title：Scientific reports

authors： Dietz S,Herz K,Gorzolka K,Jandt U,Bruelheide H,Scheel D

更新日期：2020-07-01 00:00:00

abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...

journal_title：Scientific reports

authors： Spadacenta S,Dicke PW,Thier P

更新日期：2019-10-25 00:00:00

abstract：:Polystyrene sulfonate (PSS), a strong polyelectrolyte, was used to prepare red photoluminescent PSS-penicillamine (PA) copper (Cu) nanoclusters (NC) aggregates, which displayed high selectivity and sensitivity to the detection of hydrogen sulfide (H2S). The size of the PSS-PA-Cu NC aggregates could be readily controll...

journal_title：Scientific reports

authors： Chen PC,Li YC,Ma JY,Huang JY,Chen CF,Chang HT

更新日期：2016-04-26 00:00:00

abstract：:Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A-C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evolution of SRLVs is ...

journal_title：Scientific reports

authors： Molaee V,Bazzucchi M,De Mia GM,Otarod V,Abdollahi D,Rosati S,Lühken G

更新日期：2020-02-10 00:00:00

abstract：:This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...

journal_title：Scientific reports

authors： Liang B,Xie L,Yang F,Makamure J,Zhang L,Pang R,Du P,Fan W,Zheng C

更新日期：2020-12-14 00:00:00

abstract：:Although re-sequencing of gene panels and mRNA expression profiling are now firmly established in clinical laboratories, in-depth proteome analysis has remained a niche technology, better suited for studying model systems rather than challenging materials such as clinical trial samples. To address this limitation, we ...

journal_title：Scientific reports

authors： Hughes CS,McConechy MK,Cochrane DR,Nazeran T,Karnezis AN,Huntsman DG,Morin GB

更新日期：2016-10-07 00:00:00

abstract：:Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been...

journal_title：Scientific reports

authors： Zhao X,Cui Q,Fu Q,Song X,Jia R,Yang Y,Zou Y,Li L,He C,Liang X,Yin L,Lin J,Ye G,Shu G,Zhao L,Shi F,Lv C,Yin Z

更新日期：2017-08-18 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...

journal_title：Scientific reports

authors： Luo Y,Qu T,Cui Y,Pan Y,Yu M,Luo H,Jia Y,Tan Z,Liu J,Zhang B

更新日期：2019-07-01 00:00:00

abstract：:Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the ...

journal_title：Scientific reports

authors： Wooff Y,Fernando N,Wong JHC,Dietrich C,Aggio-Bruce R,Chu-Tan JA,Robertson AAB,Doyle SL,Man SM,Natoli R

更新日期：2020-02-10 00:00:00

abstract：:The presence of non-poplar extracts, cutin, and wax layer in the wheat straw outer surface (WOS) greatly limit its application in bio-composite preparation. In this study, a dielectric-barrier-discharge plasma using water vapor as feeding gas was used to fast modify the WOS. The morphology, free radical concentrations...

journal_title：Scientific reports

authors： Chen W,Xu Y,Shi S,Cao Y,Chen M,Zhou X

更新日期：2018-02-02 00:00:00

abstract：:Predicting the occurrence of ventricular tachyarrhythmia (VTA) in advance is a matter of utmost importance for saving the lives of cardiac arrhythmia patients. Machine learning algorithms have been used to predict the occurrence of imminent VTA. In this study, we used a one-dimensional convolutional neural network (1-...

journal_title：Scientific reports

authors： Taye GT,Hwang HJ,Lim KM

更新日期：2020-04-21 00:00:00

abstract：:Crossmodal studies have reported not only facilitatory but also inhibitory perceptual interactions. For instance, tactile stimulation to the index finger of a hand leads to the degradation of visual discrimination performance (touch-induced visual suppression, TIVS). It has been suggested that the magnitude of TIVS de...

journal_title：Scientific reports

authors： Hidaka S,Suzuishi Y,Ide M,Wada M

更新日期：2018-11-19 00:00:00

abstract：:Selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. Since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by multiple components of the immune system, gaining a better understandi...

journal_title：Scientific reports

authors： Kloch A,Wenzel MA,Laetsch DR,Michalski O,Bajer A,Behnke JM,Welc-Falęciak R,Piertney SB

更新日期：2018-05-30 00:00:00