The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus.

abstract：:We report a case of the rare porokeratosis variant porokeratosis ptychotropica (PP). A circumferential perianal plaque and the characteristic histology of multiple cornoid lamellae with underlying dermal amyloid deposition were seen. Amyloid deposition was seen in the biopsied intertriginous area of the plaque only, w...

journal_title：Clinical and experimental dermatology

authors： Tallon B,Blumental G,Bhawan J

更新日期：2009-12-01 00:00:00

abstract：:Three patients with subungual exostoses, two involving the great toe and one the fourth toe, are presented. Local excision was performed, and the specimens were processed for light and electron microscopy. Light-microscopic study revealed that the tumours consisted of a proliferative fibrocartilaginous cap that merged...

journal_title：Clinical and experimental dermatology

authors： Kato H,Nakagawa K,Tsuji T,Hamada T

更新日期：1990-11-01 00:00:00

abstract：:We describe a 26-year-old Indian man who presented with chickenpox and subsequently developed pemphigus vulgaris 17 days after initial resolution of lesions. The mechanism of progression from one disease to the other is postulated to be that of epitope spreading or molecular mimicry. ...

journal_title：Clinical and experimental dermatology

authors： Goon AT,Tay YK,Tan SH

更新日期：2001-11-01 00:00:00

abstract：:A 69-year-old woman presented with a nonhealing ulcer on her right cheek. On histological examination of a biopsy, no evidence of granuloma formation or malignancy was found, and the overall picture was felt to be consistent with dermatitis artefacta (DA). The patient was referred to a joint psychodermatology clinic, ...

journal_title：Clinical and experimental dermatology

authors： Lowry CL,Bewley A,Taylor R

更新日期：2013-07-01 00:00:00

abstract：:A patient is reported who developed dysplastic naevi at an early age. He also suffered from a syndrome including Wilms' tumour, aniridia, mental retardation and diabetes mellitus in association with an interstitial deletion of the short arm of chromosome 11. It is suggested that genetic factors may be important in spo...

journal_title：Clinical and experimental dermatology

authors： McDonagh AJ,Wright AL,Messenger AG

更新日期：1990-01-01 00:00:00

abstract：:A 93-year-old woman with an 8-year history of episodes of fixed drug eruption due to paracetamol is described. The rash was characterized by bullae, crusted lesions, hyperpigmented and erythematous patches as well as lesions resembling toxic epidermal necrolysis. Direct immunofluorescence revealed deposition of IgG an...

journal_title：Clinical and experimental dermatology

authors： Duhra P,Porter DI

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Vitiligo is an acquired pigmentation disorder, which can have a negative effect on patient quality of life (QoL). AIM:To evaluate QoL and psychiatric comorbidity in paediatric patients with vitiligo. METHODS:In total, 30 patients aged 8-18 years who were diagnosed with vitiligo and 30 age- and sex-matched ...

journal_title：Clinical and experimental dermatology

authors： Ucuz I,Altunisik N,Sener S,Turkmen D,Kavuran NA,Marsak M,Colak C

更新日期：2020-02-16 00:00:00

abstract：:Azathioprine is used in a variety of dermatological conditions. However, because of its side-effect profile, azathioprine is limited for use in patients with severe disease. An unpredictable, rare and potentially fatal side-effect of azathioprine is the development of a hypersensitivity reaction, often consisting of f...

journal_title：Clinical and experimental dermatology

authors： Knowles SR,Gupta AK,Shear NH,Sauder D

更新日期：1995-07-01 00:00:00

abstract：:Waldenström macroglobulinaemia (WM) is a chronic lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraprotein. Specific cutaneous features of WM include neoplastic cell infiltrates, IgM storage papules and IgM bullous dermatosis. We report a patient with subepidermal bullous disease assoc...

journal_title：Clinical and experimental dermatology

authors： Chattopadhyay M,Rytina E,Dada M,Bhogal BS,Groves R,Handfield-Jones S

更新日期：2013-12-01 00:00:00

abstract：:Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare lichenoid dermatosis defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of horny follicular papules variously located. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed an...

journal_title：Clinical and experimental dermatology

authors： Bianchi L,Paro Vidolin A,Piemonte P,Carboni I,Chimenti S

更新日期：2001-09-01 00:00:00

abstract：:Polymorphisms of the IL-10 promoter have been implicated in the genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single-nucleotide polymorphisms (SNPs) within the interleukin-10 promoter region (-3575T/A, -2763A/C, -1082G/A and -592C/A) were analysed in 139 patients wit...

journal_title：Clinical and experimental dermatology

authors： Wongpiyabovorn J,Hirankarn N,Ruchusatsawat K,Yooyongsatit S,Asawanonda P,Poovorawan Y

更新日期：2008-03-01 00:00:00

abstract：:Secukinumab is an interleukin (IL)-17 monoclonal antibody inhibiting T-helper (Th)1-mediated immune response. It has proven high efficacy for moderate to severe psoriasis but data on its long-term toxicities are limited. We describe two patients who received secukinumab for clinically presumed psoriasis, but were subs...

journal_title：Clinical and experimental dermatology

authors： Yoo J,Shah F,Velangi S,Stewart G,Scarisbrick JS

更新日期：2019-06-01 00:00:00

abstract：:Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed--sometimes with life-threatening consequences. We report a case of isoniazid-induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid...

journal_title：Clinical and experimental dermatology

authors： Darvay A,Basarab T,McGregor JM,Russell-Jones R

更新日期：1999-05-01 00:00:00

abstract：:Renal itch is localized or generalized itch, affecting patients with chronic renal failure, where there is no primary skin disease and no systemic or psychological dysfunction that might cause pruritus. It does not result from raised serum urea levels. The prevalence of renal itch has increased with the growing popula...

journal_title：Clinical and experimental dermatology

authors： Murphy M,Carmichael AJ

更新日期：2000-03-01 00:00:00

abstract：:Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onse...

journal_title：Clinical and experimental dermatology

authors： Hegarty AM,Barrett AW,Scully C

更新日期：2004-01-01 00:00:00

abstract：:Histology sections from 61 cases of squamous cell carcinoma (SCC) of the vulva presenting after 1988 were reviewed for evidence of associated epithelial abnormality. Of the 50 patients with epithelium adjacent to the tumour, 24 had histological evidence of lichen sclerosus (LS), 20 of severe vulvar intraepithelial neo...

journal_title：Clinical and experimental dermatology

authors： Zaki I,Dalziel KL,Solomonsz FA,Stevens A

更新日期：1996-09-01 00:00:00

abstract：:Sensitive skin (SS) is a widespread condition, but still not completely understood. To identify risk factors that increase the likelihood of SS, 258 women aged between 20 and 65 years old and resident in the Netherlands were surveyed by questionnaire, which included questions on sociodemographic characteristics (age g...

journal_title：Clinical and experimental dermatology

authors： Falcone D,Richters RJH,Uzunbajakava NE,van Erp PEJ,van de Kerkhof PCM

更新日期：2017-08-01 00:00:00

abstract：:Dermatofibromata are common benign dermal tumours of unknown aetiology. They usually present as a single lesion on the limbs of young adults. Multiple dermatofibromata have been reported occurring in patients with autoimmune disease, who were receiving immunosuppressive treatment. A 25-year-old female is reported who ...

journal_title：Clinical and experimental dermatology

authors： Stainforth J,Goodfield MJ

更新日期：1994-01-01 00:00:00

abstract：:We report 20 patients who contracted cutaneous leishmaniasis in Central and South America, 18 of them in Belize. The diagnosis was confirmed by the polymerase chain reaction (PCR) in 79% of those tested; the corresponding figure for histology was 62%, touch smear 46%, and culture 11%. Results of PCR can be falsely pos...

journal_title：Clinical and experimental dermatology

authors： Palmer RA,Tran D,Hepburn NC,Ashton RE

更新日期：2001-01-01 00:00:00

abstract：:Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

journal_title：Clinical and experimental dermatology

authors： Patel AN,Cohen SN,Leach IH,Scharrer K

更新日期：2012-04-01 00:00:00

abstract：:Xanthomas are important clinical manifestations of disordered lipid metabolism, which are mostly found in patients with familial hypercholesterolaemia (FH), an inherited disorder that is predominantly caused by mutations in the low-density lipoprotein receptor gene (LDLR). Tuberous and tendinous xanthomas with wide di...

journal_title：Clinical and experimental dermatology

authors： Kong MX,Zhang Q,Cao L,Zhao C,Ru GQ,Bi Q

更新日期：2015-10-01 00:00:00

abstract：:Refractory leg ulcers in two patients healed following splenectomy. Neither patient had the ethnic background or family history of haematological abnormalities to suggest a haemoglobinopathy. ...

journal_title：Clinical and experimental dermatology

authors： Lawrence P,Aronson I,Saxe N,Jacobs P

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Immune reconstitution inflammatory syndrome (IRIS) occurs in 10-25% of unselected patients starting highly active antiretroviral therapy (HAART). About 52-78% of these cases involve cutaneous features. AIM:To describe the prevalence and incidence of new dermatological conditions within 6 months of patients ...

journal_title：Clinical and experimental dermatology

authors： Osei-Sekyere B,Karstaedt AS

更新日期：2010-07-01 00:00:00

abstract：:A lighter or whiter complexion is socially desirable in many cultures. This has led to an unregulated and highly profitable market in skin-lightening creams that are readily available over the counter or on the internet. Plant extracts and newer tyrosinase inhibitors such as kojic acid or its derivative kojic dipalmit...

journal_title：Clinical and experimental dermatology

authors： Madhogaria S,Ahmed I

更新日期：2010-06-01 00:00:00

abstract：:Ten patients with plaque-type psoriasis were treated by applying semi-permeable hydrocolloid dressings (Com-feel, Coloplast, Denmark) and the effect compared to untreated skin. The treatment effect was evaluated by: (a) O2-consumption as measured by a TCM-2 oxygen-monitor; (b) blood flow as measured by laser-Doppler f...

journal_title：Clinical and experimental dermatology

authors： Broby-Johansen U,Kristensen JK

更新日期：1989-07-01 00:00:00

abstract：:Immunosuppression is recognized to predispose to the development of disseminated superficial actinic porokeratosis and to cause the spread of pre-existing lesions. Porokeratosis of Mibelli has been less frequently described following immunosuppression and we report a further case. ...

journal_title：Clinical and experimental dermatology

authors： Wilkinson SM,Cartwright PH,English JS

更新日期：1991-01-01 00:00:00

abstract：:Japan is currently experiencing many outbreaks of scabies, occurring mainly in long-term care facilities. Scabies burrows, the only pathognomonic lesion for scabies, often occur on the creases of the palms, and are followed by a pattern of scale reminiscent of the 'wake' left on the surface of water by a moving bird o...

journal_title：Clinical and experimental dermatology

authors： Yoshizumi J,Harada T

更新日期：2009-08-01 00:00:00

abstract：:Ichthyosis hystrix, Curth-Macklin type (IHCM) is an extremely rare autosomal dominant dermatosis caused by mutations in the keratin genes, KRT1 or KRT10, which often manifests as extensive, dark, spiky or verrucous plaques and severe palmoplantar keratoderma. We report a novel frameshift truncation mutation, c.1596_15...

journal_title：Clinical and experimental dermatology

authors： Yang Z,Xu Z,Zhang N,Ma L

更新日期：2020-08-01 00:00:00

abstract：:We report a patient with purely cutaneous Rosai-Dorfman disease (RDD) who presented with a solitary, asymptomatic plaque on the back of her left thigh, with characteristic, large histiocytoid cells exhibiting emperipolesis histologically. Cutaneous lesions occur in 27% of patients with lymph node involvement in RDD ho...

journal_title：Clinical and experimental dermatology

authors： Child FJ,Fuller LC,Salisbury J,Higgins EM

更新日期：1998-01-01 00:00:00

abstract：:Asymmetrical periflexural exanthem is a rare clinical condition, seen almost exclusively in children. Very few adult cases have been reported in the literature. We report a case of this rare eruption in an adult man showing characteristic clinical and histological features. Interestingly, this patient also exhibited a...

journal_title：Clinical and experimental dermatology

authors： Dar NR,Raza N

更新日期：2009-10-01 00:00:00