Abstract:
:Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly develop resistance to currently used antifungal agents. Resistance to the class of azoles, which are still widely used agents, varies in proportion (from 5 to 20%) depending on geographical area. Moreover, resistance to the class of echinocandins, which was introduced in the late 1990s, is rising in several institutions. The recent emergence of isolates with acquired resistance to both classes of agents is a major concern since alternative therapeutic options are scarce. Although considered less pathogenic than C. albicans, C. glabrata has still evolved specific virulence traits enabling its survival and propagation in colonized and infected hosts. Development of drug resistance is usually associated with fitness costs, and this notion is documented across several microbial species. Interestingly, azole resistance in C. glabrata has revealed the opposite. Experimental models of infection showed enhanced virulence of azole-resistant isolates. Moreover, azole resistance could be associated with specific changes in adherence properties to epithelial cells or innate immunity cells (macrophages), both of which contribute to virulence changes. Here we will summarize the current knowledge on C. glabrata drug resistance and also discuss the consequences of drug resistance acquisition on the balance between C. glabrata and its hosts.
journal_name
FEMS Yeast Resjournal_title
FEMS yeast researchauthors
Vale-Silva LA,Sanglard Ddoi
10.1093/femsyr/fov025subject
Has Abstractpub_date
2015-06-01 00:00:00pages
fov025issue
4eissn
1567-1356issn
1567-1364pii
fov025journal_volume
15pub_type
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journal_title:FEMS yeast research
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journal_title:FEMS yeast research
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.12004.x
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.2012.00823.x
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abstract::The Saccharomyces cerevisiae allantoate/ureidosuccinate permease gene (DAL5) is often used as a reporter in studies of the Tor1/2 protein kinases which are specifically inhibited by the clinically important immunosuppressant and anti-neoplastic drug, rapamycin. To date, only a single type of cis-acting element has bee...
journal_title:FEMS yeast research
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journal_title:FEMS yeast research
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fow008
更新日期:2016-03-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.2009.00505.x
更新日期:2009-06-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.2006.00201.x
更新日期:2007-08-01 00:00:00
abstract::Schizosaccharomyces pombe Cap1 has been identified as the (adenylyl) cyclase-associated protein. Cap1 was able to bind Cap1 itself and actin. Cap1 localized at the growing tip, and this localization was dependent on the Cap1 P2 region. In a two-hybrid screening using cap1 as bait, we isolated csh3, which encodes a pro...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fov097
更新日期:2015-12-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fow072
更新日期:2016-11-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fow076
更新日期:2016-11-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章,评审
doi:10.1111/j.1567-1364.2010.00665.x
更新日期:2010-12-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fow073
更新日期:2016-09-01 00:00:00
abstract::Endosomal sorting complexes required for transport (ESCRTs) are involved in the formation of multivesicular bodies and sorting of targeted proteins to the yeast vacuole. The deletion of seven genes encoding components of the ESCRT machinery render Saccharomyces cerevisiae cells sensitive to high extracellular CaCl2 co...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fov007
更新日期:2015-03-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1016/j.femsyr.2004.09.002
更新日期:2005-02-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/1567-1364.12147
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.2007.00239.x
更新日期:2007-09-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1016/j.femsyr.2005.05.004
更新日期:2005-12-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/1567-1364.12014
更新日期:2013-03-01 00:00:00
abstract::The feasibility of using a single vector to clone a cytochrome P450 monooxygenase (P450) in different yeasts and then compare whole-cell hydroxylase activity was investigated. A broad-range yeast expression vector using the ylTEFp to drive expression of the cloned gene and the scTEFp to drive the hygromycin resistance...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/1567-1364.12142
更新日期:2014-06-01 00:00:00
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journal_title:FEMS yeast research
pub_type: 杂志文章,评审
doi:10.1093/femsyr/fow084
更新日期:2016-11-01 00:00:00
abstract::In yeast, rRNA genes can be detected with the FISH technique using rRNA gene probes. This technique yields reliable, reproducible and precise results, but is time-consuming. Here, the primed in situ DNA synthesis (PRINS) procedure has been optimized for rapid detection of yeast rRNA genes. PRINS, which is as sensitive...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/j.1567-1364.2009.00499.x
更新日期:2009-06-01 00:00:00
abstract::Previous work has shown that the synthetic lethality of the slt2Δrim101Δ mutant results from a combination of factors, including improper functioning of the septum assembly machinery. Here, we identify new multicopy suppressors of this lethality including Kss1, Pcl1 and Sph1, none of which seems to be linked to the up...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/fow060
更新日期:2016-09-01 00:00:00
abstract::The microbial consortium of wine fermentations is highly dependent upon winemaking decisions made at crush, including the decision to inoculate and the decision to add sulfur dioxide (SO2) to the must. To investigate this, Chardonnay grape juice was subjected to two inoculation treatments (uninoculated and pied de cuv...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1093/femsyr/foz049
更新日期:2019-08-01 00:00:00
abstract::Messenger RNAs retained in the nucleus of Saccharomyces cerevisiae are subjected to a degradation system designated DRN (Degradation of mRNA in the Nucleus) that is dependent on the nuclear mRNA cap-binding protein, Cbc1p, as well as nuclear exosome component Rrp6p, a 3' to 5' exoribonuclease. DRN has been shown to ac...
journal_title:FEMS yeast research
pub_type: 杂志文章
doi:10.1111/1567-1364.12180
更新日期:2014-09-01 00:00:00
abstract::The mechanism involved in the cellular phosphate response of Saccharomyces cerevisiae forms part of the PHO pathway, which upon expression allows a co-ordinated cellular response and adaptation to changes in availability of external phosphate. Although genetic studies and analyses of the S. cerevisiae genome have prod...
journal_title:FEMS yeast research
pub_type: 杂志文章,评审
doi:10.1111/j.1567-1364.2006.00036.x
更新日期:2006-03-01 00:00:00