Abstract:
:A comprehensive transcriptome analysis of an expressed sequence tag (EST) database of the spider Dolomedes fimbriatus venom glands using single-residue distribution analysis (SRDA) identified 7,169 unique sequences. Mature chains of 163 different toxin-like polypeptides were predicted on the basis of well-established methodology. The number of protein precursors of these polypeptides was appreciably numerous than the number of mature polypeptides. A total of 451 different polypeptide precursors, translated from 795 unique nucleotide sequences, were deduced. A homology search divided the 163 mature polypeptide sequences into 16 superfamilies and 19 singletons. The number of mature toxins in a superfamily ranged from 2 to 49, whereas the diversity of the original nucleotide sequences was greater (2-261 variants). We observed a predominance of inhibitor cysteine knot toxin-like polypeptides among the cysteine-containing structures in the analyzed transcriptome bank. Uncommon spatial folds were also found.
journal_name
Sci Datajournal_title
Scientific dataauthors
Kozlov SA,Lazarev VN,Kostryukova ES,Selezneva OV,Ospanova EA,Alexeev DG,Govorun VM,Grishin EVdoi
10.1038/sdata.2014.23subject
Has Abstractpub_date
2014-08-05 00:00:00pages
140023issn
2052-4463journal_volume
1pub_type
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