Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients.

Abstract:

BACKGROUND:Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. OBJECTIVES:This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B patients. PATIENTS AND METHODS:In this study, we evaluated 151 treatment naive chronic hepatitis B patients and grouped them according to their HBeAg status. Serum hepatitis B virus (HBV) DNA and HBsAg levels were measured, and liver function tests, and liver biopsy were performed for the study population. RESULTS:There was a significant difference in age, and HBV DNA and HBsAg levels between HBeAg-negative and HBeAg-positive groups yet there was no statistically significant difference in sex, liver function tests, grading and staging of liver biopsy between the groups. Hepatitis B virus DNA and HBsAg levels were correlated in both HBeAg-negative and HBeAg-positive chronic hepatitis B patients. CONCLUSIONS:We concluded that chronic hepatitis B patients had different HBV DNA and HBsAg levels according to their HBeAg status.

authors

Keshvari M,Alavian SM,Sharafi H

doi

10.5812/jjm.21444

subject

Has Abstract

pub_date

2015-01-14 00:00:00

pages

e21444

issue

3

eissn

2008-3645

issn

2008-4161

journal_volume

8

pub_type

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