Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia.

Abstract:

OBJECTIVE:To determine the frequency of the transforming growth factor-alpha (TGFalpha) Taq1 polymorphism in nonsyndromic cleft lip with or without cleft palate (CL+/-P) and cleft palate only (CP) in Kelantan, Malaysia. SETTING:The study was conducted at the Combined Cleft Clinic and at the Human Genome Centre in Hospital Universiti Sains Malaysia in Kelantan, Malaysia. DESIGN:We examined the C2/Taq1 variant of the TGFalpha gene in 46 patients with nonsyndromic CL+/-P or CP only and in 33 controls. The TGFalpha genotype frequencies in patients were compared with those in controls using the chi-square or Fisher exact test. DNA samples were obtained from peripheral blood. RESULTS:No association was found between TGFalphaTaq1 polymorphism and CL+/-P or CP in this case-control study. In addition, no homozygosity for the rare allele C2 was noted in CL+/-P, CP, or the controls. CONCLUSION:No evidence of TGFalphaTaq1 polymorphism was observed in association with CL+/-P and CP in this study.

authors

Rahman RA,Ahmad A,Rahman ZA,Mokhtar KI,Lah NA,Zilfalil BA,Samsudin AR

doi

10.1597/07-020.1

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

583-6

issue

6

eissn

1055-6656

issn

1545-1569

pii

07-020

journal_volume

45

pub_type

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