A Gonadotropin-Releasing Hormone (GnRH) Stimulation Test Before and After GnRH Analogue Treatment for Central Precocious Puberty: Has the GnRH Test been Adequately Simplified?

Abstract:

OBJECTIVE:To investigate and simplify the gonadotropin-releasing hormone (GnRH) stimulation test for assessing pubertal activation and suppression. METHODS:The authors identified 72 girls diagnosed with central precocious puberty who were treated with a GnRH analogue (GnRHa). Patients who underwent an assessment regarding GnRHa-mediated puberty suppression had been diagnosed via the GnRH stimulation test prior to GnRHa treatment. The authors analyzed the diagnostic values of the during/before-treatment LH levels at different time points by a receiver-operating characteristic (ROC) curve. RESULTS:Before GnRHa treatment, the mean luteinizing hormone (LH) level was higher at the 30-min test time point than at baseline or the 15, 60, 90, and 120-min points (P < 0.001). After GnRHa treatment, the LH levels were suppressed in 62 patients (86.1%) and inadequately suppressed in 10 (13.9%). The LH level was higher at the 30-min test time point than those at baseline or the 45 and 60-min level (P < 0.001). The area under the curve in a post-GnRHa treatment was greatest at 30 min. CONCLUSIONS:The simplified GnRH test is adequate for evaluating pubertal activation (30 and/or 45-min time points of the GnRH test) and suppression (the 30-min time point).

journal_name

Indian J Pediatr

authors

Kim MS,Hwang PH,Lee DY

doi

10.1007/s12098-015-1761-z

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

996-1000

issue

11

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-015-1761-z

journal_volume

82

pub_type

杂志文章
  • MRI Customized Play Therapy in Children Reduces the Need for Sedation--A Randomized Controlled Trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of an MRI-specific play therapy intervention on the need for sedation in young children. METHODS:All children in the age group of 4-10 y, who were advised an MRI scan over a period of one year were randomized. Exclusion criteria included children with neurodevelopmental disorder...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12098-015-1917-x

    authors: Bharti B,Malhi P,Khandelwal N

    更新日期:2016-03-01 00:00:00

  • Recent advances in improved tuberculosis vaccines.

    abstract::Tuberculosis continues to be a major infectious cause of global morbidity and mortality, both in children and adults, in spite of widespread vaccination of infants with Bacille Calmette-Guerin (BCG) and the availability of effective antibiotics. The failure of BCG to significantly affect disease incidence in adults in...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: McMurray DN

    更新日期:2000-02-01 00:00:00

  • Ultrasound Examination of Pediatric Musculoskeletal Diseases and Neonatal Spine.

    abstract::Ultrasound (US) is a simple, non-invasive imaging modality which allows high-resolution imaging of the musculoskeletal (MSK) system. Its increasing popularity in pediatrics is due to the fact that it does not involve radiation, has an ability to visualize non-ossified cartilaginous and vascular structures, allows dyna...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-015-1957-2

    authors: Karnik AS,Karnik A,Joshi A

    更新日期:2016-06-01 00:00:00

  • Pathophysiology and current management of necrotizing enterocolitis.

    abstract::Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of morbidity and mortality in these infants. In this article, the authors review the pathophysiology and clinical presentation of NEC and provide a critical appraisal of t...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-014-1388-5

    authors: Kasivajjula H,Maheshwari A

    更新日期:2014-05-01 00:00:00

  • Status epilepticus in Indian children in a tertiary care center.

    abstract:OBJECTIVE:To study the clinical profile, immediate outcome and possible risk factors of SE in pediatric age group admitted to pediatric intensive care unit (PICU) in a tertiary care center. METHODS:A retrospective study of case records of 451 neuroemergency patients admitted in PICU in a tertiary care center between J...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02760691

    authors: Gulati S,Kalra V,Sridhar MR

    更新日期:2005-02-01 00:00:00

  • Approach to a child with sore throat.

    abstract::Sore throat is one of the common reasons for outpatient and emergency visits among children. It could be because of several etiologies; of these bacterial pharyngitis is the most important. Major challenge for the clinician is to diagnose group A beta hemolytic streptococcus (GABHS) pharyngitis and diphtheria, which a...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-011-0467-0

    authors: Shah R,Bansal A,Singhi SC

    更新日期:2011-10-01 00:00:00

  • Impact of Leadership of Trained Intensivist in Pediatric Intensive Care Unit in a Middle Income Country: An Uncontrolled Before-After Study.

    abstract:OBJECTIVE:To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes. METHODS:This study was a retrospective observational study conducted in the 16-bedded PICU of a tertiary referral center. Two years (2013-2015) period of the PICU without a...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-019-03154-5

    authors: Kesici S,Bayrakci B

    更新日期:2020-04-01 00:00:00

  • CVID enteropathy- a rare cause of chronic diarrhea in a child.

    abstract::Common variable immunodeficiency (CVID) is a rare primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections especially in respiratory and gastrointestinal systems. The authors present here a case of CVID with uncommon gastrointestinal manifestation in the form of CVID e...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0635-2

    authors: Patel J,Kumar A,Agasti A,Choksey A,Phadke A,Sawant P

    更新日期:2012-10-01 00:00:00

  • Association of celiac disease with aplastic anemia.

    abstract::The authors report a case of 13-y-old boy who presented with pain in bilateral knee and ankle joints accompanied by petechiae all over the body and hematochezia. On investigation, he had pancytopenia, which on subsequent evaluation revealed aplastic anemia. On investigation for short stature, he was diagnosed as a cas...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0579-6

    authors: Maheshwari A,Nirupam N,Aneja S,Meena R,Chandra J,Kumar P

    更新日期:2012-10-01 00:00:00

  • Stem cell therapy: challenges ahead.

    abstract::Stem cells have generated great interest for their potential therapeutic use because of their capacity to self-renew indefinitely and to generate all cell lineages (pluripotency). Many diseases such as neurodegenerative disorders or diabetes are caused by loss of functionality or deficiency of a particular cell type. ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-014-1521-5

    authors: Bhagavati S

    更新日期:2015-03-01 00:00:00

  • Effect of physical and mental activity on blood pressure.

    abstract:OBJECTIVES:The authors measured and recorded the physical (outdoor playing) and mental (home study) activity behavior and blood pressure amongst school going children and observed their association with the blood pressure levels. METHOD:It was a cross sectional school-based study from 12 primary schools; selected by s...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF02724095

    authors: Thakor HG,Kumar P,Desai VK

    更新日期:2004-04-01 00:00:00

  • Somatizing disorders affecting the respiratory tract.

    abstract::Respiratory disease in childhood is common but not all children presenting to the paediatrician have an underlying organic cause for their symptoms. This article reviews the spectrum of non-organic somatization disorders that might be encountered and advises about the diagnosis and treatment of habit cough, laryngeal ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02726188

    authors: Connett GJ

    更新日期:2000-02-01 00:00:00

  • Process evaluation of pulse polio immunisation in Delhi.

    abstract::The aim of the study was to assess the functional aspects and the staffing at Pulse Polio immunisations posts. Interns and medical students conducted the survey in eighty seven pulse polio immunisation posts scattered all over National Capital Territory of Delhi on 18th January 1997. A pre-tested structured format con...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02730902

    authors: Kumar P,Pandit K,Chhabra P,Bhasin S,Aggarwal OP

    更新日期:1998-07-01 00:00:00

  • Askin tumor: a malignant small cell tumor.

    abstract::Malignant tumours of the chest wall are rare in the pediatric age group. Askin tumour, a primitive neuroectodermal tumour with aggressive nature, is extremely rare. Clinico-pathological features make it quite distinct from Ewing's sarcoma. Aggressive nature of the tumour results in short clinical presentation of the p...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02726235

    authors: Aggarwal M,Lakhhar B,Aggarwal BK,Anugu R

    更新日期:2000-11-01 00:00:00

  • Paracetamol poisoning in children.

    abstract::Paracetamol (acetaminophen) has become an antipyretic drug of choice. Due to its widespread use, toxicity secondary to overdose has increased in recent years. Children are especially vulnerable to accidental exposure due to non availability of child proof containers in India. The main clinical features of acute toxici...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02761132

    authors: Lall SB,Paul R

    更新日期:1998-05-01 00:00:00

  • Hirschsprung Disease - Current Diagnosis and Management.

    abstract::Hirschsprung disease is a common cause of neonatal and infantile large gut obstruction. It is characterised by varying extent of contiguous aganglionosis extending from the anorectum proximally. Since its recognition, the diagnosis and management has continuously evolved with advances in histological evaluation and su...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-017-2371-8

    authors: Das K,Mohanty S

    更新日期:2017-08-01 00:00:00

  • Psychosocial problems in families of children with cancer.

    abstract:OBJECTIVE:The aim of this study is to assess the effect of diagnosis of cancer on the parents, to study the coping response adopted by the child and the family and to evolve counseling strategies. METHODS:Prospective questionnaire based. Thirty-four parents of children suffering from cancer were included, of which 15 ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-007-0149-0

    authors: Rajajee S,Ezhilarasi S,Indumathi D

    更新日期:2007-09-01 00:00:00

  • Pediatric Interventional Radiology: Non-Vascular Interventions.

    abstract::Pediatric interventional radiology (PIR), which includes variety of procedures done under image guidance has emerged as an essential adjunct to various surgical and medical conditions, plays a significant role in the delivery of safe and effective care by reducing surgical risks, decreasing the length of hospital stay...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-015-1987-9

    authors: Kandasamy D,Gamanagatti S,Gupta AK

    更新日期:2016-07-01 00:00:00

  • Care in diabetic emergencies.

    abstract::A review is presented on the care of three diabetic emergencies: diabetic ketoacidosis (DKA), hypoglycemias and sick days. A treatment scheme, based on low-dose insulin regime and i.v. insulin administration is presented. Plenty of emphasis is laid on fluid and electrolyte therapy. It is stressed that the primary goal...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02776468

    authors: Akerblom HK,Kaprio EA

    更新日期:1989-11-01 00:00:00

  • Separation of thoraco-omphalopagus Siamese twin.

    abstract::A pair of female thoraco-omphalopagus twins, with two pairs of lungs, common diaphragm and separate pleural cavities was separated at the age of 5(1/2) months after a parasitic relationship had developed between them. Before separation both the babies developed recurrent respiratory tract infection and frequent diarrh...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02730669

    authors: Ray AK,Mukherjee NN,Mukherjee G,Patra R,Ghosh DK

    更新日期:2004-08-01 00:00:00

  • Left ventricular failure due to a rare variant of congenital adrenal hyperplasia.

    abstract::"Hypertensive" variant of congenital adrenal hyperplasia is rare. The authors describe an interesting case of a 6-y-old boy who presented with an acute respiratory illness and progressive breathlessness since 1 y. Genital hyperpigmentation was noticed since 2 y of age; the onset of pubarche and increasing penile size ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0649-9

    authors: Bhatia S,Muranjan MN,Lahiri KR

    更新日期:2012-09-01 00:00:00

  • Monitoring Treatment of Childhood Tuberculosis and the Role of Therapeutic Drug Monitoring.

    abstract::Most children tolerate the first-line antibiotics used to treat Mycobacterium tuberculosis (TB) very well. The most common adverse effect is gastrointestinal distress unrelated to hepatotoxicity; the latter is seen in less than 1% of children. Despite the infrequency of hepatotoxicity, the potential long-term impact o...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-019-02882-y

    authors: Cruz AT,Starke JR

    更新日期:2019-08-01 00:00:00

  • Effect of gender, birth weight and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia.

    abstract::Blood samples from 813 newborns were spotted on to filter paper and the 17-hydroxyprogesterone concentration was measured using the Delfia (R) fluorometric immunoassay. The median, mean, and standard deviation (SD) for the total population were 20, 21 and (11) nmol/L respectively. Males had significantly higher levels...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02761890

    authors: al-Nuaim AR,Abdullah MA,Stevens B,Zain M

    更新日期:1995-09-01 00:00:00

  • Allergenicity of common foods restricted in respiratory allergy.

    abstract::Although hypersensitivity to foods is often linked to exacerbations of symptoms of respiratory allergy, no such information is available regarding the foods traditionally considered to play a probable etiological role in respiratory allergy in India, which are in fact quite different from the ones implicated in the We...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02723925

    authors: Sharman J,Kumar L,Singh S

    更新日期:2000-10-01 00:00:00

  • Rectal involvement in neutropenic enterocolitis.

    abstract::Neutropenic enterocolitis is a common gastrointestinal complication in children undergoing chemotherapy for a variety of malignancies. It usually involves ileum and caecum, and involvement of rectum has rarely been reported. The authors report neutropenic enterocolitis in a child undergoing chemotherapy for acute lymp...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0506-x

    authors: Gupta S,Kapoor S,Ravi RN,Prakash A,Aggarwal SK

    更新日期:2012-04-01 00:00:00

  • Risk factors for low birth weight in Nepali infants.

    abstract::A detailed information on a total of 448 consecutive Nepali births which occurred between January 1, 1985 and December 31, 1994 was collected from the birth registers of the Khasi-Jaintia Presbetyrian Synod Hospital of Shillong, Meghalaya. After the exclusion of still and twin births, and the cases of missing informat...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02760471

    authors: Mondal B

    更新日期:2000-07-01 00:00:00

  • Diagnosis and management of acyanotic heart disease: part II -- left-to-right shunt lesions.

    abstract::In this review, the clinical features and management of most commonly encountered acyanotic, left-to-right shunt lesions are discussed. Patients with small defects, especially in childhood, are usually asymptomatic while moderate to large defects in infancy may present with symptoms. Hyperdynamic precordium, widely sp...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02724429

    authors: Syamasundar Rao P

    更新日期:2005-06-01 00:00:00

  • Accidental inorganic mercury chloride poisoning in a 2-year old child.

    abstract::Inorganic mercury poisoning is uncommon, but when it occurs it can result in severe, life threatening features and acute renal failure. A 2-year old well thriving child presented with alleged history of accidental ingestion of inorganic mercury chloride. He presented with evidence of corrosive trauma to the gastrointe...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-010-0143-9

    authors: Verma S,Kumar R,Khadwal A,Singhi S

    更新日期:2010-10-01 00:00:00

  • Prooxidant-antioxidant balance in perinatal asphyxia.

    abstract:OBJECTIVE:To determine the prooxidant-antioxidant balance (PAB) in neonatal asphyxia and compare it with values for PAB in healthy neonates. METHODS:In a prospective observational study, serum PAB of umbilical cord blood of 30 neonates with asphyxia [pH < 7.2, low Apgar score, signs of respiratory distress syndrome (R...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-013-1239-9

    authors: Boskabadi H,Navaee Boroujeni A,Mostafavi-Toroghi H,Hosseini G,Ghayour-Mobarhan M,Hamidi Alamdari D,Biranvandi M,Saber H,Ferns GA

    更新日期:2014-03-01 00:00:00

  • Management of Non-Hodgkin Lymphoma: ICMR Consensus Document.

    abstract::Hitherto poor outcomes, paucity of data and heterogeneity in International approach to Pediatric NHL (Non-Hodgkin Lymphoma) prompted the need for guidelines for Indian population with vast variability in access, affordability and infrastructure across the country. These guidelines are based on consensus among the expe...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-017-2318-0

    authors: Thacker N,Bakhshi S,Chinnaswamy G,Vora T,Prasad M,Bansal D,Agarwala S,Kapoor G,Radhakrishnan V,Laskar S,Kaur T,Rath GK,Dhaliwal RS,Arora B

    更新日期:2017-05-01 00:00:00