Abstract:
:The acute chest syndrome (ACS) is the main cause of mortality among adult patients with sickle cell disease (SCD). Its pathophysiology is still unclear. Using positron emission tomography (PET) with F-fluorodeoxyglucose [18F-fluorodeoxyglucose (F-FDG)], we explored the relationship between regional lung density and lung metabolism, as a reflection of lung neutrophilic infiltration during ACS.Patients were prospectively enrolled in a single-center study. Dual modality chest PET/computed tomography (CT) scans were performed, with F-FDG emission scans for quantification of regional F-FDG uptake and CT scans with radiocontrast agent to check for pulmonary artery thrombosis. Regional lung F-FDG uptake was quantified in ACS patients and in SCD patients without ACS (SCD non-ACS controls). Maximal (SUVmax) and mean (SUVmean) standardized uptake values were computed.Seventeen patients with ACS (mean age 28.3 ± 6.4 years) were included. None died nor required invasive mechanical ventilation. The main lung opacity on CT scans was lower lobe consolidation. Lungs of patients with ACS exhibited higher SUVmax than those of SCD non-ACS controls (2.5 [2.1-2.9] vs 0.8 [0.6-1.0]; P < 0.0001). Regional SUVmax and SUVmean was higher in lower than in upper lobes of ACS patients (P < 0.001) with a significant correlation between lung density and SUVmax (R = 0.78). SUVmean was higher in upper lobes of ACS patients than in lungs of SCD non-ACS controls (P < 0.001). Patients with SUVmax >2.5 had longer intensive care unit (ICU) stay than others (7 [6-11] vs 4 [3-6] days; P = 0.016).Lungs of patients with ACS exhibited higher F-FDG uptake than SCD non-ACS controls. Lung apices had normal aeration and lower F-FDG uptake than lung bases, but higher F-FDG uptake than lungs of SCD non-ACS controls. Patients with higher lung F-FDG uptake had longer ICU stay than others.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
de Prost N,Sasanelli M,Deux JF,Habibi A,Razazi K,Galactéros F,Meignan M,Maître B,Brun-Buisson C,Itti E,Dessap AMdoi
10.1097/MD.0000000000000821subject
Has Abstractpub_date
2015-05-01 00:00:00pages
e821issue
18eissn
0025-7974issn
1536-5964pii
00005792-201505020-00010journal_volume
94pub_type
临床试验,杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Cyclin B plays a crucial role in cancer cell cycle progression and is overexpressed in many human cancers, including breast cancer. However, the prognostic value of cyclin B expression in breast cancer is controversial. We performed a meta-analysis to assess the clinicopathological and prognostic significanc...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000006860
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The receptor for advanced glycosylation end products (RAGE) has been widely linked to diabetic atherosclerosis, but its effects on coronary artery disease (CAD) and ischemic stroke (IS) remain controversial. The Gly82Ser polymorphism is located in the ligand-binding V domain of RAGE, suggesting a possible in...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000005593
更新日期:2016-12-01 00:00:00
abstract::The aim of our study was to investigate the relationship between the waist-to-height ratio (WHR) and all-cause mortality and functional outcomes after acute ischemic stroke in a prospective cohort study.A total of 2076 patients (36.66% females) with ischemic stroke were analyzed from ACROSS-China, which is a nationwid...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000006520
更新日期:2017-03-01 00:00:00
abstract::The manometry with water-perfused or solid-state catheters is the predominant diagnostic procedure to detect motility disorders of the esophagus. Another method is the manometry using gas-perfused catheters. Although the high-resolution manometry is the method of first choice, the conventional manometry with helium ha...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009910
更新日期:2018-02-01 00:00:00
abstract::Pedicle screws are widely used in spinal surgeries, but it remains technically demanding to place. There are numerous studies on the anatomy of pedicle; however, there is very little insight on the relationship between the pedicle and the spinous process, which is an important part of the spinal posterior column.The a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006732
更新日期:2017-05-01 00:00:00
abstract::Alveolar echinococcosis is a chronically progressive and potentially fatal disease. Patients with multiple giant alveolar echinococcosis have a poor prognosis when radical resection cannot be achieved, but curative resection can be limited by low future remnant liver volumes. In these cases, 2-stage liver resection ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007819
更新日期:2017-08-01 00:00:00
abstract:RATIONALE:This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient. PATIENT CONCERNS:A 14-month-old boy was...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014105
更新日期:2019-01-01 00:00:00
abstract::Posthepatectomy liver failure (PHLF) is the main cause of perioperative death, and liver cirrhosis is one of the most important risk factors for PHLF. Spleen stiffness (SS) is a novel ultrasonic indicator for liver cirrhosis and portal hypertension, however, it is not clear that whether it has a significant influence ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015458
更新日期:2019-05-01 00:00:00
abstract:RATIONALE:Eclampsia, an obstetric emergency frequently seen in pregnant or puerperal women, is a risk factor for posterior reversible encephalopathy syndrome (PRES). Most cases of eclampsia occur postpartum. We report a woman with PRES associated with eclampsia 10 weeks post-delivery, the latest onset ever reported. P...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015187
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007484
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Over one-third of human immunodeficiency virus (HIV)-infected pregnant women are clinically depressed, increasing the risk of mother-to-child transmission (MTCT) of HIV, as well as negative birth and child development outcomes. This study will evaluate the efficacy and cost-effectiveness of an evidence-bas...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000016329
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:This study is a prospective, assessor-blinded, parallel-group, randomized controlled pilot trial to explore the effectiveness of 12-week adjuvant moxibustion therapy for arthralgia in menopausal females at stage I to III breast cancer on aromatase inhibitor (AI) administration, compared with those receivin...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000017260
更新日期:2019-09-01 00:00:00
abstract::To determine the utility of low kilovoltage computed tomographic venography (CTV) for the detection of deep venous thrombus in the lower limbs.Twenty-one thrombi in 19 enrolled patients were investigated in this retrospective study. Patients were initially scanned using CTV at 100 kVp, at the femur level, followed by ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009775
更新日期:2018-02-01 00:00:00
abstract:RATIONALE:X-linked dominant hypophosphatemia rickets (XLH, OMIM 307800) is the most common hereditary hypophosphatemic rickets and characterized by growth retardation, skeletal malformations, dental dysplasia, spontaneous fractures and osteomalacia. PHEX gene was identified for XLH and novel mutations were consistent w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011453
更新日期:2018-08-01 00:00:00
abstract::The aim of the study was to evaluate the clinical effect of the limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis (DLSS) with instability. Hemilaminectomy decompression, intervertebral fusion, and pedicle screw fixation for treating DLSS with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018277
更新日期:2019-12-01 00:00:00
abstract::The first case of atypical pneumonia caused by coronavirus disease 2019 (COVID-19) was reported in Wuhan, China in December 2019. Since then, cases of novel coronavirus-infected pneumonia (NCIP) have been reported throughout China as well as in 25 other countries. With the rapid growth of this global outbreak, psychol...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021662
更新日期:2020-08-21 00:00:00
abstract:BACKGROUND:Pneumonia is the second leading cause of death in children worldwide after preterm birth and certification. Bacteria, viruses, mycoplasma, and other microorganisms are known to be the main causes of pneumonia, of which bacterial pathogenic factors account for 12.5% of cases. The invention and application of ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023217
更新日期:2020-12-11 00:00:00
abstract:RATIONALE:Achromobacter xylosoxidans infection is mostly reported in immunocompromised patients. Until now, it is still rarely reported in patients undergoing peritoneal dialysis. PATIENT CONCERNS:This is the 1st case of A xylosoxidans infection due to tunnel infection of a Tenckhoff catheter. DIAGNOSIS:The diagnosis...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006654
更新日期:2017-04-01 00:00:00
abstract::Prostate cancer (PCa) is a highly aggressive malignant tumor and the biological mechanisms underlying its progression remain unclear.We performed weighted gene co-expression network analysis in PCa dataset from the Cancer Genome Atlas database to identify the key module and key genes related to the progression of PCa....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021158
更新日期:2020-07-10 00:00:00
abstract::Kinesin family member 2A (KIF2A) is a member of Kinesin-13 family and involved in cell migration and cell signaling. Human epidermal growth factor receptor 2 (HER2-neu) is implicated in the development of many cancers. Both of these 2 proteins are upstream inducer of PI3K/AKT signaling pathway that plays an important ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002803
更新日期:2016-02-01 00:00:00
abstract:RATIONALE:Treprostinil, a potent vasodilator, is the treatment of choice for severe pulmonary arterial hypertension (PAH) during pregnancy. Its inhibition of platelet aggregation increases the risk of hemorrhage. In addition, anticoagulation therapy is widely used in pregnancy with PAH due to the hypercoagulable state....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011810
更新日期:2018-08-01 00:00:00
abstract::Coronary artery disease (CAD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Patients with CKD who undergo percutaneous coronary intervention (PCI) may have more ischemic events than patients without CKD. The aim of our study was to determine the incidence of periprocedural myocardial...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005381
更新日期:2016-11-01 00:00:00
abstract::Heart rate variability (HRV) is an objective measure of emotional regulation. This study aimed to estimate the accuracy with which an artificial neural network (ANN) algorithm could classify emotions using HRV data that were obtained using wristband heart rate monitors.Four emotions were evoked during gameplay: pleasu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016863
更新日期:2019-08-01 00:00:00
abstract::Gynecologic vasculitis (GynV) has been reported as part of systemic vasculitis (SGynV) and as single-organ (isolated gynecologic) vasculitis (IGynV). In the current study, we analyzed the clinical and histologic characteristics of patients with GynV and sought to identify features that differentiate the isolated from ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181a577f3
更新日期:2009-05-01 00:00:00
abstract:RATIONALE:Hypernatremia is a rare but fatal complication of hypertonic saline (HS) irrigation in hepatic hydatid disease. It needs careful monitoring and treatment. PATIENT CONCERNS:A 28-year-old woman with hepatic hydatid cysts who received operation treatment developed electrolyte disturbances. We also conducted a r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007889
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The objective of this study is to evaluate the accuracy of radionuclide in diagnosis of bone metastasis (BM) after breast cancer surgery (BCS). METHODS:The electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CBM, and CNKI) will be systematically and comprehensively searched until June 1...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021585
更新日期:2020-08-14 00:00:00
abstract::The objective of this study was to compare the differences between the measurements performed manually to those obtained using a digital model scanner of patients with orthodontic treatment.A cross-sectional study was performed in a sample of 30 study models from patients with permanent dentition who attended a univer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010887
更新日期:2018-06-01 00:00:00
abstract::Retrospective radiographic analysis.To determine the fusion rate of stand-alone lateral lumbar interbody fusion (LLIF). Biomechanical studies have indicated that LLIF may be more stable than anterior or transforaminal lumbar interbody fusion. Early clinical reports of stand-alone LLIF have shown success in obtaining f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000275
更新日期:2014-12-01 00:00:00
abstract::Nonspecific ST-segment and T-wave (ST-T) changes represent one of the most prevalent electrocardiographic abnormalities in hypertensive patients. However, a limited number of studies have investigated the association between nonspecific ST-T changes and unsatisfactory blood pressure (BP) control in adults with hyperte...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006423
更新日期:2017-03-01 00:00:00
abstract::There is an increased interest in extending surgical criteria for pancreatic cancer by performing pancreaticoduodenectomy (PD) combined with portal vein (PV) or superior mesenteric vein (SMV) resection and reconstruction for borderline resectable patients. However, whether this procedure suitable for elderly patients ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007335
更新日期:2017-07-01 00:00:00