Abstract:
:When Alzheimer's disease (AD) progresses, several pathological features arise including accumulation of misfolded protein aggregates [e.g., amyloid-β (Aβ) plaques], metal ion dyshomeostasis, and oxidative stress. These characteristics are recently suggested to be interconnected through a potential factor, metal-associated Aβ (metal-Aβ) species. The role of metal-Aβ species in AD pathogenesis remains unclear, however. To elucidate the contribution of metal-Aβ species to AD pathology, as well as to develop small molecules as chemical tools and/or theranostic (therapeutic and diagnostic) agents for this disease, curcumin (Cur), a natural product from turmeric, and its derivatives have been studied towards both metal-free and metal-induced Aβ aggregation. Although Cur has indicated anti-amyloidogenic activities and antioxidant properties, its biological use has been hindered due to low solubility and stability in physiologically relevant conditions. Herein, we report the reactivity of Cur and its derivatives (Gd-Cur, a potential multimodal Aβ imaging agent; Cur-S, a water soluble derivative of Cur that has substitution at the phenolic hydroxyls) with metal-free Aβ and metal-Aβ species. Our results and observations indicate that Gd-Cur could modulate Cu(II)-triggered Aβ aggregation more noticeably over metal-free or Zn(II)-induced analogues; however, Cur-S was not observed to noticeably modulate Aβ aggregation with and without metal ions. Overall, our studies present information that could aid in optimizing the molecular scaffold of Cur for the development of chemical tools or theranostics for metal-Aβ species.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Kochi A,Lee HJ,Vithanarachchi SM,Padmini V,Allen MJ,Lim MHdoi
10.2174/1567205012666150504150125subject
Has Abstractpub_date
2015-01-01 00:00:00pages
415-23issue
5eissn
1567-2050issn
1875-5828pii
CAR-EPUB-67024journal_volume
12pub_type
杂志文章abstract::Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205013666160314145347
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2018-02-22 00:00:00
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doi:10.2174/156720510791383859
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doi:10.2174/156720510790691218
更新日期:2010-03-01 00:00:00
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journal_title:Current Alzheimer research
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更新日期:2012-09-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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journal_title:Current Alzheimer research
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更新日期:2014-01-01 00:00:00
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journal_title:Current Alzheimer research
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更新日期:2018-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Current Alzheimer research
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doi:10.2174/1567205016666181212155147
更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
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更新日期:2014-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205011666140130150108
更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:2014-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/156720501108140910123112
更新日期:2014-01-01 00:00:00
abstract::Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/156720509787602843
更新日期:2009-04-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/156720508783884620
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205016666190725155038
更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current Alzheimer research
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doi:10.2174/15672050113106660176
更新日期:2014-01-01 00:00:00
abstract::In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205013666160620114309
更新日期:2017-01-01 00:00:00