Maternal Anxiety and the Second-Trimester Prenatal Screening: A Prospective Cohort Study.

Abstract:

OBJECTIVE:Assessing the effects of maternal anxiety on the markers and results of quadruple screening and on maternal anxiety after receiving positive results. METHODS:This prospective cohort study evaluated 1,595 pregnant women referred for prenatal visits. Maternal state/trait anxiety levels were measured, then quadruple screening was performed by measuring serum α-fetoprotein (AFP), β-human chorionic gonadotropin, inhibin A, and unconjugated estriol (UE3). After receiving the results, the state/trait anxiety was remeasured. Amniocentesis was performed for screening-positive mothers. RESULTS:High prescreening maternal anxiety was associated with lower rates of elevated AFP (OR, 0.27; 95% CI, 0.1-0.74) and elevated inhibin A (OR, 0.38; 95% CI, 0.15-0.98). High maternal anxiety was associated with higher rates of decreased UE3 (OR, 1.8; 95% CI, 1.06-3.08). There were no significant associations between prescreening maternal anxiety and the final screening or amniocentesis results. Among the screening-positive mothers, those who had high state/trait anxiety before screening had higher anxiety scores after receiving positive results compared to those with low prescreening anxiety levels (52.9 ± 10.8 vs. 43.7 ± 10.3). CONCLUSION:High prescreening maternal anxiety is associated with lower rates of elevated AFP and inhibin A and higher rates of decreased UE3. However, maternal anxiety does not affect the final screening or amniocentesis result. High maternal state/trait anxiety before screening is associated with significantly higher maternal anxiety after the receipt of positive results.

journal_name

Fetal Diagn Ther

authors

Mousavi S,Hantoushzadeh S,Sheikh M,Shariat M

doi

10.1159/000381640

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

269-75

issue

4

eissn

1015-3837

issn

1421-9964

pii

000381640

journal_volume

38

pub_type

杂志文章
  • Ominous normalization of middle cerebral artery flow velocity waveforms preceding fetal death: case report.

    abstract::The loss of middle cerebral artery compensatory vasodilation appears to be ominous in fetuses with absent end-diastolic umbilical waveforms. The authors report a case with a loss of the 'brain-sparing effect' 24 h before fetal death. Current pathophysiological explanations are discussed. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264215

    authors: Chitrit Y,Zorn B,Filidori M,Bucourt M,Chasseray JE,Caubel P

    更新日期:1995-03-01 00:00:00

  • Bidirectional communication between neural and cardiac cells in human amniotic fluid.

    abstract:OBJECTIVE:To evaluate whether amniotic fluid cells contain cardiomyocyte- and neuron-like cells. STUDY DESIGN:In this experimental study, cells from human amniotic fluid samples were analyzed for mRNA expression of microtubule-associated protein 2 (MAP-2), vimentin and oxytocin (OT) receptor via RT-PCR. Immunocytochem...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000200016

    authors: Stefanidis K,Loutradis D,Anastasiadou V,Dinopoulou V,Eleni E,Arampatzi E,Lekka K,Mesogitis S,Antsaklis A

    更新日期:2009-01-01 00:00:00

  • Fetal intraventricular bleeding possibly due to maternal vitamin K deficiency.

    abstract::We report a rare case of fetal intraventricular bleeding possibly due to maternal vitamin K deficiency. A 20-year-old woman was admitted to our hospital due to impending premature delivery and loss of dietary intake at 28 weeks of gestation. Her blood examination showed metabolic alkalosis, prolonged prothrombin time,...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000163078

    authors: Minami H,Furuhashi M,Minami K,Miyazaki K,Yoshida K,Ishikawa K

    更新日期:2008-01-01 00:00:00

  • Two-Dimensional Ultrasound Evaluation of the Fetal Cerebral Aqueduct: Improving the Antenatal Diagnosis and Counseling of Aqueductal Stenosis.

    abstract:OBJECTIVE:To describe a technique for the visualization and measurement of cerebral aqueduct diameter through a 2D sagittal median plane, and to report its aspect and measurement in fetuses with aqueductal stenosis (AS). METHODS:This was a cross-sectional study of 207 morphologically normal fetuses in low-risk pregnan...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000458439

    authors: Viñals F,Ruiz P,Quiroz G,Guerra FA,Correa F,Martínez D,Puerto B

    更新日期:2017-01-01 00:00:00

  • Evaluation of fetal echogenic bowel in the second trimester.

    abstract::Previous studies cite different possible etiologies for fetal echogenic bowel (FEB). The purpose of this study was to evaluate the possible etiologies for second-trimester FEB, and to provide clinical guidelines for evaluation of this finding. The study included 79 patients diagnosed with FEB in the second trimester. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020914

    authors: Yaron Y,Hassan S,Geva E,Kupferminc MJ,Yavetz H,Evans MI

    更新日期:1999-05-01 00:00:00

  • Correlation of abnormal rapid FISH and chromosome results from amniocytes for prenatal diagnosis.

    abstract::Rapid fluorescence in situ hybridization (FISH) performed on 1,788 amniocenteses, using Aneuvision (Vysis) probes for chromosomes 13, 18, 21, X, and Y, over several years, yielded 115 cases with percentages of aneuploidy between 4 and 100%. All cases above 60% were confirmed to be positive by chromosome analysis. Fift...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000089310

    authors: Wyandt HE,Tonk VS,Huang XL,Evans AT,Milunsky JM,Milunsky A

    更新日期:2006-01-01 00:00:00

  • Reassuring fetal middle cerebral artery doppler velocimetry in alloimmunised pregnancies: neonatal outcomes without invasive procedures.

    abstract:OBJECTIVE:To assess the neonatal outcome in red blood cell alloimmunised pregnancies at increased risk of fetal anaemia where invasive testing was avoided based on reassuring middle cerebral artery (MCA) Doppler velocity results. METHODS:We included 28 alloimmunised pregnant women at significant risk of fetal or neona...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000086809

    authors: Abdel-Fattah SA,Shefras J,Kyle PM,Cairns P,Hunter A,Soothill PW

    更新日期:2005-09-01 00:00:00

  • Fetal heart disease: severity, associated anomalies and parental decision.

    abstract:OBJECTIVE:This study describes the association between the complexity of congenital cardiac and extracardiac malformations, and the parental decision of pregnancy continuation or termination. METHODS:Congenital heart defects (CHD) was diagnosed by ultrasound in 251 fetuses before the 24th week (23 + 6 weeks) of gestat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000346564

    authors: Nell S,Wijngaarde CA,Pistorius LR,Slieker M,ter Heide H,Manten GT,Freund MW

    更新日期:2013-01-01 00:00:00

  • Identification of Macrosomic, normal and intrauterine growth retarded neonates using the modified Neonatal Growth Assessment Score.

    abstract:OBJECTIVE:Separation of Macrosomic, normal and intrauterine growth retarded (IUGR) neonates using the modified Neonatal Growth Assessment Score (NGAS). METHODS:A sample of 23 neonates with evidence of growth acceleration and 74 neonates classified as normal or IUGR in a previous study was used in this investigation. T...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000074262

    authors: Deter RL,Spence LR

    更新日期:2004-01-01 00:00:00

  • Levels of maternal serum angiogenic factors in third-trimester normal pregnancies: reference ranges, influence of maternal and pregnancy factors and fetoplacental Doppler indices.

    abstract:AIM:To establish normal ranges of maternal placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PlGF ratio at 32-41 weeks' gestation and to evaluate the influence of maternal characteristics, and of fetoplacental Doppler. MATERIAL AND METHODS:Serum levels of PlGF, sFlt-1 and sFlt-1/Pl...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000360078

    authors: Lobmaier SM,Figueras F,Mercade I,Crovetto F,Peguero A,Parra-Saavedra M,Ortiz JU,Crispi F,Gratacós E

    更新日期:2014-01-01 00:00:00

  • Prenatal diagnosis of fetal cardiac right ventricular diverticulum disappearing at three months of age. A case report and literature review.

    abstract::Congenital cardiac diverticula are transmural localized protrusions within the free wall of the ventricles. Right ventricular diverticula are rarely diagnosed during the fetal period, and due to their rarity, their natural history remains unclear. We present a case of prenatal diagnosis of right ventricular diverticul...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000196815

    authors: Perlitz Y,Mukary M,Lorber A,Ben-Ami M

    更新日期:2009-01-01 00:00:00

  • Maternal renal and interlobar arteries waveforms evaluation with color Doppler ultrasound in pregnancy-induced hypertension.

    abstract::The authors performed a color Doppler ultrasound examination of both renal and interlobar arteries of 15 pregnant women affected by pregnancy-induced hypertension. The pulsatility index (PI), the resistance index (RI) and the systolic/diastolic ratio (S/D) values were compared with those of 15 healthy pregnant women o...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264292

    authors: Boemi G,Bruno MT,La Ferrera G,Butera L,Pulvirenti G,Lanzone A,Mancuso S

    更新日期:1996-03-01 00:00:00

  • Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review.

    abstract::Fetal dextrocardia is a type of cardiac malposition where the major axis from base to apex points to the right side. This condition is usually associated with a wide spectrum of complex cardiac defects. As a result, dextrocardia is conceptually difficult to understand and diagnose on prenatal ultrasound. The advantage...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000468929

    authors: Yeo L,Luewan S,Markush D,Gill N,Romero R

    更新日期:2018-01-01 00:00:00

  • Leiden mutation, bed rest and infection: simultaneous triggers for maternal deep-vein thrombosis and neonatal intracranial hemorrhage?

    abstract::The possible etiologic roles of infection and bed rest are discussed in connection with a case of maternal homozygous Leiden mutation leading to prematurity, maternal deep-vein thrombosis and neonatal intracranial hemorrhage in a heterozygous premature baby. Maternal bacterial infection and bed rest may trigger deep-v...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000076711

    authors: Sikovanyecz J,Orvos H,Pál A,Katona M,Endreffy E,Horváth E,Szabó J

    更新日期:2004-05-01 00:00:00

  • Feasibility of retroviral vector-mediated in utero gene transfer to the fetal rabbit.

    abstract:OBJECTIVES:Successful treatment or prevention of severe hereditary diseases could conceivably be achieved by genetic intervention early in development. Viral vector-mediated fetal gene transfer is proving a valuable tool to test the above concept in relevant animal models. Although the pregnant rabbit is a well-recogni...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000088036

    authors: Moreno R,Rosal M,Cabero L,Gratacós E,Aran JM

    更新日期:2005-11-01 00:00:00

  • Echocardiographic risk stratification of fetuses with sacrococcygeal teratoma and twin-reversed arterial perfusion.

    abstract:OBJECTIVE:To evaluate pre-intervention echocardiographic parameters of cardiac function in fetuses who survive without hydrops as compared to fetuses who develop hydrops or perinatal death in the setting of sacrococcygeal teratoma (SCT) and twin-reversed arterial perfusion sequence (TRAP). METHODS:Clinical, echocardio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000330762

    authors: Byrne FA,Lee H,Kipps AK,Brook MM,Moon-Grady AJ

    更新日期:2011-01-01 00:00:00

  • The early amniocentesis study: a randomized clinical trial of early amniocentesis and midtrimester amniocentesis. II. Evaluation of procedure details and neonatal congenital anomalies.

    abstract::The present study provides detailed neonatal and congenital malformation follow-up from 695 women enrolled in a prospective randomized multicenter study comparing the safety and accuracy of early (11-12 weeks of gestation) and midtrimester amniocentesis (15-16 weeks of gestation). No differences were found for total p...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000264440

    authors: Wilson RD,Johnson J,Windrim R,Dansereau J,Singer J,Winsor EJ,Kalousek D

    更新日期:1997-03-01 00:00:00

  • Amniopatch treatment for spontaneous previable, preterm premature rupture of membranes associated or not with incompetent cervix.

    abstract:OBJECTIVE:We reviewed women with previable spontaneous premature rupture of membranes (sPPROM) in whom an amniopatch was performed and compared their pregnancy outcomes with a conservative management group. METHODS:Amniopatch, an amnioinfusion of autologous platelet concentrate followed by cryoprecipitate, was perform...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000342418

    authors: Kwak HM,Choi HJ,Cha HH,Yu HJ,Lee JH,Choi SJ,Oh SY,Roh CR,Kim JH

    更新日期:2013-01-01 00:00:00

  • Monozygotic twinning as a congenital defect and congenital defects in monozygotic twins.

    abstract::The process of monozygotic twinning in animals and humans is presented. In addition, congenital defects in monozygotic twins versus dizygotic twins and singletons is discussed. Overall, the rates of congenital anomalies are higher among whites as compared to blacks, males as compared to females, and multiples as compa...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263545

    authors: Luke B,Keith LG

    更新日期:1990-01-01 00:00:00

  • Fetal pathology in second-trimester miscarriages.

    abstract:OBJECTIVE:We aimed to analyze, based upon autopsy, the main characteristics of miscarriages in the second trimester. METHODS:We have processed the results of fetopathological investigations of 544 aborted fetuses resulting from 486 second-trimester miscarriages. RESULTS:Malformation could be identified in 13.05% of a...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000210832

    authors: Joó JG,Beke A,Berkes E,Papp Z,Rigó J Jr,Papp C

    更新日期:2009-01-01 00:00:00

  • Think of the Conus Medullaris at the Time of Diagnosis of Fetal Sacral Agenesis.

    abstract:BACKGROUND:There is no precise prenatal indicator to refine an accurate prognosis in case of sacral agenesis and to define the diagnostic approach and outcome criteria in case of fetal sacral agenesis using 3 characteristics of the conus medullaris (CM): its position, its appearance, and associated spinal abnormalities...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000451080

    authors: Mottet N,Martinovic J,Baeza C,Guimiot F,Bault JP,Aubry MC,Riethmuller D,Zerah M,Cretolle C,Benachi A

    更新日期:2017-01-01 00:00:00

  • First trimester diagnosis of sirenomelia by 2D and 3D ultrasound.

    abstract::A case of sirenomelia in a 27-year-old woman detected at 11 weeks 5 days of gestation is presented. It was suspected by two-dimensional sonography and color Doppler imaging. Three-dimensional ultrasound confirmed the final diagnosis. With detailed evaluation of the acquired volumes, valuable information was obtained a...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000236359

    authors: Contu R,Zoppi MA,Axiana C,Ibba RM,Monni G

    更新日期:2009-01-01 00:00:00

  • Thoraco-amniotic shunting.

    abstract::Thoraco-amniotic shunting was performed in 51 singleton pregnancies for decompression and chronic drainage of fetal pleural effusions (n = 47), pericardial effusion (n = 1), or pulmonary cysts (n = 3). Five fetuses had chromosomal defects and in 4 the parents elected termination of pregnancy. All 18 non-hydropic fetus...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263586

    authors: Nicolaides KH,Azar GB

    更新日期:1990-01-01 00:00:00

  • Hemimegalencephaly: 2D, 3D Ultrasound and MRI Correlation.

    abstract:BACKGROUND:Hemimegalencephaly (HMC) is a disorder associated with enlarged and dysplastic hamartomatous overgrowth of all or part of the one cerebral hemisphere that can be isolated or associated with other syndromes. In the normal development of the brain it is important to bear in mind that there are two main process...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000322012

    authors: Romero XC,Molina FS,Pastor E,Amaya F

    更新日期:2011-01-01 00:00:00

  • Successful fetal intervention for congenital high airway obstruction syndrome.

    abstract:INTRODUCTION:Complete congenital high airway obstruction syndrome (CHAOS) usually leads to stillbirth or death within minutes of delivery. We describe the management and long-term follow-up of a baby with a prenatally diagnosed airway obstruction. CASE:Because of progressive hydrops fetalis, massive ascites and everte...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000063179

    authors: Paek BW,Callen PW,Kitterman J,Feldstein VA,Farrell J,Harrison MR,Albanese CT

    更新日期:2002-09-01 00:00:00

  • Screening for Sex Chromosome Aneuploidy by Cell-Free DNA Testing: Patient Choice and Performance.

    abstract:OBJECTIVE:To study patient choice regarding testing for sex chromosome aneuploidy (SCA) and the performance of cell-free DNA (cfDNA) screening for SCA. METHODS:Patient choice regarding screening for SCA and factors influencing this choice were evaluated in a single center. In a subsequent two-center study, cases that ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000479507

    authors: Bevilacqua E,Ordóñez E,Hurtado I,Rueda L,Mazzone E,Cirigliano V,Jani JC

    更新日期:2018-01-01 00:00:00

  • Human embryonic stem cells form embryoid bodies containing visceral endoderm-like derivatives.

    abstract:OBJECTIVE:The objective of this study was to determine the potential of human embryonic stem (hES) cells to provide an in vitro model of human extraembryonic endoderm development. METHODS:The hES cell line HES-2 was propagated in Dulbecco's modification of Eagle's medium (DMEM) in the presence of 20% fetal calf serum ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000076701

    authors: Conley BJ,Trounson AO,Mollard R

    更新日期:2004-05-01 00:00:00

  • Co-inheritance of β- and δ-thalassemia compromising prenatal screening in a Chinese couple seeking prevention.

    abstract::Although δ-globin gene mutations have no clinical implications, association of β- and δ-thalassemia may lead to misdiagnosis. We describe the case of a Chinese woman who was assumed to have an α-thalassemia heterozygote, but was later shown to have β-thalassemia with a normal amount of HbA(2) caused by the -77 mutatio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000321046

    authors: Li J,Xie XM,Zhou JY,Li DZ

    更新日期:2011-01-01 00:00:00

  • Debate about ultrasound screening policies.

    abstract::Routine ultrasound examination is defined as a screening procedure performed on the total obstetric population usually at 18-20 weeks of gestation as opposed to the selective use of ultrasound that might provide more information for a problem that is suspected on clinical grounds. Standard ultrasound examination inclu...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000020840

    authors: Antsaklis AJ

    更新日期:1998-07-01 00:00:00

  • Prenatal diagnosis of lissencephaly by magnetic resonance image.

    abstract::Two cases of lissencephaly were prenatally diagnosed by a magnetic resonance image (MRI). Smooth surface of brain and remarkable sylvian fissure, which were barely detectable by ultrasound, were easily observed in MRI. MRI is the most appropriate tool in diagnosing lissencephaly. ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263748

    authors: Okamura K,Murotsuki J,Sakai T,Matsumoto K,Shirane R,Yajima A

    更新日期:1993-01-01 00:00:00