Abstract:
BACKGROUND:The activity of angiotension converting enzyme (ACE; OMIM: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ACE in psychiatric disorders. Genetic polymorphism of insertion/deletion (I/D; dbSNP rs4646994) in the gene encoding ACE has been well defined. METHODS:The present case-control study was performed on 363 (268 males, 95 females) in-patients with schizophrenia diagnosis, and 363 (268 males, 95 females) healthy blood donor controls. The genotypes of I/D ACE polymorphism were determined using PCR method. PCR products were separated and sized by electrophoresis on a 2% agarose gel. The insertion allele (I) was detected as a 478 bp band, and the deletion allele (D) was visualized as a 191 bp band. The association between genotypes of the I/D polymorphism and the schizophrenia risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs). RESULTS:Among females, the II genotype significantly decreased the risk of schizophrenia compared with the DD genotype (OR=0.18, 95%CI: 0.04-0.72, P=0.015). There was significant linear trend for the number of the I allele and schizophrenia risk among females (Chi(2)=5.19, P=0.023). There was no significant association between I/D polymorphism and susceptibility to schizophrenia among male subjects. There was significant interaction between gender and the II genotype (P=0.031). CONCLUSION:The II genotype of the I/D polymorphism has a protective effect for schizophrenia among females.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Mazaheri H,Saadat Msubject
Has Abstractpub_date
2015-03-01 00:00:00pages
369-73issue
3eissn
2251-6085issn
2251-6093journal_volume
44pub_type
杂志文章abstract:BACKGROUND:To extract utility values of diabetic retinopathy on a perfect health and perfect vision scales for Iranians with both types diabetes. METHODS:In this investigation, 150 untreated patients with diabetic retinopathy consecutively were examined and interviewed in Farabi Eye Hospital, Tehran, Iran, a tertiary ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Cholera epidemics have a recorded history in eastern Congo dating to 1971. A study was conducted to find out the linkage between climate variability/change and cholera outbreak and to assess the related economic cost in the management of cholera in Congo. METHODS:This study integrates historical data (20 ye...
journal_title:Iranian journal of public health
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更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the association between physical inactivity and academic record in Korean adolescents. METHODS:Adolescent students from the first grade of middle school to the third grade of high school (n=75,066) participated in the 5th Korea Youth Risk Behavior Web-based Surve...
journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::Congenital Nail abnormalities are rare ectodermal defects. Autosomal recessive nail dysplasia is much rarer. Recently it has been recognized as a condition resulting in nail dystrophy in the absence of other cutaneous or extracutaneous disorders. Few case reports have identified mutations in the Frizzled 6 (FZD6) gene...
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journal_title:Iranian journal of public health
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更新日期:2016-11-01 00:00:00
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journal_title:Iranian journal of public health
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journal_title:Iranian journal of public health
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journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2014-06-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2018-07-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2019-12-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2014-03-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2018-11-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The centralization of human activities is associated with different pollutants which enter into environment easily and cause the urban environment more vulnerable. Regarding the importance of air pollution issue for Tehran metropolis, many plans and regulations have been developed. However, most of them fail...
journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2015-07-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2015-05-01 00:00:00
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journal_title:Iranian journal of public health
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journal_title:Iranian journal of public health
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journal_title:Iranian journal of public health
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更新日期:2018-07-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2012-01-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2011-01-01 00:00:00
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journal_title:Iranian journal of public health
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更新日期:2012-01-01 00:00:00
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journal_title:Iranian journal of public health
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journal_title:Iranian journal of public health
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