Abstract：
:Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis and is typically associated with chronic viral infection. Alcohol-induced and non-alcoholic steatohepatitis are two rising hepatic problems. The innate immune inflammasome signaling cascade mediates the production of essential proinflammatory cytokines interleukin-1β (IL-1β) and IL-18. These cytokines regulate hepatic cell interaction and crosstalk of the various inflammatory pathways and influence disease outcome.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Negash AA,Gale M Jrdoi
10.1111/imr.12279subject
Has Abstractpub_date
2015-05-01 00:00:00pages
143-55issue
1eissn
0105-2896issn
1600-065Xjournal_volume
265pub_type
杂志文章,评审abstract：:As biomedical research becomes increasingly data-intensive, it is increasingly essential to integrate genomic-scale datasets, so as to generate a more holistic picture of complex biological processes. The systems biology paradigm may differ in strategy from traditional reductionist scientific methods, but the goal rem...
journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1987.tb00509.x
更新日期：1987-04-01 00:00:00
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更新日期：2002-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2008.00721.x
更新日期：2009-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2008.00631.x
更新日期：2008-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2010-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1984.tb00479.x
更新日期：1984-04-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2018-11-01 00:00:00
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doi：10.1111/j.1600-065X.2012.01130.x
更新日期：2012-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01288.x
更新日期：1999-04-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/imr.12266
更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2011.01045.x
更新日期：2011-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,收录出版,评审
doi：10.1034/j.1600-065x.2001.1830118.x
更新日期：2001-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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更新日期：2012-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1991.tb00584.x
更新日期：1991-02-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2019-01-01 00:00:00
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doi：10.1111/j.1600-065x.1997.tb00947.x
更新日期：1997-02-01 00:00:00
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journal_title：Immunological reviews
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doi：10.1034/j.1600-0528.2002.00021h.x
更新日期：2000-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01298.x
更新日期：1999-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01186.x
更新日期：1998-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12112
更新日期：2013-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2010.00983.x
更新日期：2011-03-01 00:00:00
abstract：:Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lympho...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2009.00884.x
更新日期：2010-03-01 00:00:00
