Efficacy and oncologic safety of nerve-sparing radical hysterectomy for cervical cancer: a randomized controlled trial.

Abstract:

OBJECTIVE:A prospective, randomized controlled trial was conducted to evaluate the efficacy of nerve-sparing radical hysterectomy (NSRH) in preserving bladder function and its oncologic safety in the treatment of cervical cancer. METHODS:From March 2003 to November 2005, 92 patients with cervical cancer stage IA2 to IIA were randomly assigned for surgical treatment with conventional radical hysterectomy (CRH) or NSRH, and 86 patients finally included in the analysis. Adequacy of nerve sparing, radicality, bladder function, and oncologic safety were assessed by quantifying the nerve fibers in the paracervix, measuring the extent of paracervix and harvested lymph nodes (LNs), urodynamic study (UDS) with International Prostate Symptom Score (IPSS), and 10-year disease-free survival (DFS), respectively. RESULTS:There were no differences in clinicopathologic characteristics between two groups. The median number of nerve fiber was 12 (range, 6 to 21) and 30 (range, 17 to 45) in the NSRH and CRH, respectively (p<0.001). The extent of resected paracervix and number of LNs were not different between the two groups. Volume of residual urine and bladder compliance were significantly deteriorated at 12 months after CRH. On the contrary, all parameters of UDS were recovered no later than 3 months after NSRH. Evaluation of the IPSS showed that the frequency of long-term urinary symptom was higher in CRH than in the NSRH group. The median duration before the postvoid residual urine volume became less than 50 mL was 11 days (range, 7 to 26 days) in NSRH group and was 18 days (range, 10 to 85 days) in CRH group (p<0.001). No significant difference was observed in the 10-year DFS between two groups. CONCLUSION:NSRH appears to be effective in preserving bladder function without sacrificing oncologic safety.

journal_name

J Gynecol Oncol

authors

Roh JW,Lee DO,Suh DH,Lim MC,Seo SS,Chung J,Lee S,Park SY

doi

10.3802/jgo.2015.26.2.90

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

90-9

issue

2

eissn

2005-0380

issn

2005-0399

pii

201504090

journal_volume

26

pub_type

杂志文章,随机对照试验
  • Treatment of the patients with abnormal cervical cytology: a "see-and-treat" versus three-step strategy.

    abstract:OBJECTIVE:To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS:A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.3.164

    authors: Cho H,Kim JH

    更新日期:2009-09-01 00:00:00

  • Randomized phase III trial comparing pegylated liposomal doxorubicin (PLD) at 50 mg/m² versus 40 mg/m² in patients with platinum-refractory and -resistant ovarian carcinoma: the JGOG 3018 Trial.

    abstract:OBJECTIVE:The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking. METHODS:This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2021.32.e9

    authors: Motohashi T,Yabuno A,Michimae H,Ohishi T,Nonaka M,Takano M,Nishio S,Fujiwara H,Fujiwara K,Kondo E,Sugiyama T,Tabata T

    更新日期:2021-01-01 00:00:00

  • Comparison of modified Cherney incision and vertical midline incision for management of early stage cervical cancer.

    abstract:OBJECTIVE:The aim of this study was to compare operative feasibility and surgical outcome of the modified Cherney incision and vertical midline incision in patients undergoing radical hysterectomy and pelvic lymphadenectomy. METHODS:Between March 2005 and December 2007, retrospective data of 78 patients (n=17; modifie...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2008.19.4.246

    authors: Lee SH,Yim GW,Lee DW,Kim SW,Kim S,Kim JW,Kim YT

    更新日期:2008-12-01 00:00:00

  • Erratum: Prevalence of germline BRCA mutations among women with carcinoma of the peritoneum or fallopian tube.

    abstract::This corrects the article on p. e43 in vol. 29, PMID: 29770616. ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,已发布勘误

    doi:10.3802/jgo.2018.29.e80

    authors: Choi MC,Bae JS,Jung SG,Park H,Joo WD,Song SH,Lee C,Kim JH,Lee KC,Lee S,Lee JH

    更新日期:2018-09-01 00:00:00

  • Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan.

    abstract:OBJECTIVE:To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. METHODS:The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.4.342

    authors: Chiang YC,Chen CA,Chiang CJ,Hsu TH,Lin MC,You SL,Cheng WF,Lai MS

    更新日期:2013-10-01 00:00:00

  • Comparison of four malignancy risk indices in the detection of malignant ovarian masses.

    abstract:OBJECTIVE:The aim of this study was to evaluate the ability of four risk of malignancy indices (RMI) to detect malignant ovarian tumors. METHODS:This is a prospective study of 100 women admitted to the Department of Obstetrics and Gynecology of Gulhane Military Medicine Academy for surgical exploration of pelvic masse...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.3.177

    authors: Aktürk E,Karaca RE,Alanbay I,Dede M,Karaşahin E,Yenen MC,Başer I

    更新日期:2011-09-01 00:00:00

  • Insulin resistance and overweight prolonged fertility-sparing treatment duration in endometrial atypical hyperplasia patients.

    abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e35

    authors: Yang B,Xie L,Zhang H,Zhu Q,Du Y,Luo X,Chen X

    更新日期:2018-05-01 00:00:00

  • Synergistic growth inhibition by combination of adenovirus mediated p53 transfer and cisplatin in ovarian cancer cell lines.

    abstract:OBJECTIVE:This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS:Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with w...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.1.48

    authors: Ryu SY,Kim K,Lee WS,Kwon HC,Lee KH,Kim CM,Kang SB

    更新日期:2009-03-01 00:00:00

  • Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. METHODS:Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 spe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.3.175

    authors: Koh SC,Huak CY,Lutan D,Marpuang J,Ketut S,Budiana NG,Saleh AZ,Aziz MF,Winarto H,Pradjatmo H,Hoan NK,Thanh PV,Choolani M

    更新日期:2012-07-01 00:00:00

  • Prognostic models for locally advanced cervical cancer: external validation of the published models.

    abstract:OBJECTIVE:To externally validate the prognostic models for predicting the time-dependent outcome in patients with locally advanced cervical cancer (LACC) who were treated with concurrent chemoradiotherapy in an independent cohort. METHODS:A historical cohort of 297 women with LACC who were treated with radical concurr...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.3802/jgo.2017.28.e58

    authors: Lora D,Gómez de la Cámara A,Fernández SP,Enríquez de Salamanca R,Gómez JFPR

    更新日期:2017-09-01 00:00:00

  • Sonographic diagnosis and Endo-SPONGE assisted vacuum therapy of anastomotic leakage following posterior pelvic exenteration for ovarian cancer without using a protective stoma.

    abstract::Anastomotic leakage is a very significant complication after posterior pelvic exenteration and a major cause of postoperative morbidity and mortality. We present a patient who underwent an optimal debulking surgery for an advanced stage ovarian cancer (FIGO IIIC). On postoperative day 12, transvaginal ultrasound revea...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.2.131

    authors: Einenkel J,Holler B,Hoffmeister A

    更新日期:2011-06-30 00:00:00

  • Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS:Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.4.265

    authors: Raungkaewmanee S,Tangjitgamol S,Manusirivithaya S,Srijaipracharoen S,Thavaramara T

    更新日期:2012-10-01 00:00:00

  • Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases.

    abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.1.59

    authors: Lee M,Jung YW,Kim SW,Kim SH,Kim YT

    更新日期:2010-03-01 00:00:00

  • The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients.

    abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e6

    authors: Di Donato V,Page Z,Bracchi C,Tomao F,Musella A,Perniola G,Panici PB

    更新日期:2019-01-01 00:00:00

  • Condom and oral contraceptive use and risk of cervical intraepithelial neoplasia in Australian women.

    abstract:OBJECTIVE:To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN). METHODS:A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.3802/jgo.2014.25.3.183

    authors: Chih HJ,Lee AH,Colville L,Xu D,Binns CW

    更新日期:2014-07-01 00:00:00

  • Erratum: Bowel resection rate but not bowel related morbidity is decreased after interval debulking surgery compared to primary surgery in patents with stage IIIC-IV ovarian cancer.

    abstract::This corrects the article on e25 in vol. 30, PMID: 30740956. ...

    journal_title:Journal of gynecologic oncology

    pub_type: 已发布勘误

    doi:10.3802/jgo.2019.30.e101

    authors: Tozzi R,Casarin J,Baysal A,Valenti G,Kilic Y,Majd HS,Morotti M

    更新日期:2019-09-01 00:00:00

  • Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization.

    abstract:OBJECTIVE:Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e27

    authors: Chang H,Hong JH,Lee JK,Cho HW,Ouh YT,Min KJ,So KA

    更新日期:2018-05-01 00:00:00

  • Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes.

    abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e25

    authors: Albert A,Lee A,Allbright R,Vijayakumar S

    更新日期:2020-05-01 00:00:00

  • Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: a Gynecologic Cancer Inter-Group (GCIG) study.

    abstract:OBJECTIVE:'The Endometrial Cancer Conservative Treatment (E.C.Co.). A multicentre archive' is a worldwide project endorsed by the Gynecologic Cancer Inter-Group, aimed at registering conservatively treated endometrial cancer (EC) patients. This paper reports the oncological and reproductive outcomes of intramucous, G2,...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e74

    authors: Falcone F,Leone Roberti Maggiore U,Di Donato V,Perrone AM,Frigerio L,Bifulco G,Polterauer S,Casadio P,Cormio G,Masciullo V,Malzoni M,Greggi S

    更新日期:2020-09-01 00:00:00

  • SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.

    abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e46

    authors: Yue Y,Xia L,Xu S,Wang C,Wang X,Lu W,Xie X

    更新日期:2020-07-01 00:00:00

  • Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: decreased incidence of the p53 signature in pregnant women.

    abstract:OBJECTIVE:To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy. METHODS:We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during ben...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e96

    authors: Ida T,Fujiwara H,Kiriu T,Taniguchi Y,Kohyama A

    更新日期:2019-11-01 00:00:00

  • Metastatic pattern of uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients.

    abstract:OBJECTIVE:To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. METHODS:We included 113 women (mean age, 53 years; range, 29 to 72 years) with histopathology-confirmed ULMS from 2000 to 2012. Distribution of metastases was noted from imaging by ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.4.306

    authors: Tirumani SH,Deaver P,Shinagare AB,Tirumani H,Hornick JL,George S,Ramaiya NH

    更新日期:2014-10-01 00:00:00

  • Efficacy and safety of neoadjuvant chemotherapy versus primary debulking surgery in patients with ovarian cancer: a meta-analysis.

    abstract:OBJECTIVE:Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. METHODS:PubMed, Embase, ClinicalTrials.gov, a...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e12

    authors: Lv X,Cui S,Zhang X,Ren C

    更新日期:2020-03-01 00:00:00

  • Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand.

    abstract:OBJECTIVE:To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS:EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death....

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2015.26.4.293

    authors: Tangjitgamol S,Khunnarong J,Srijaipracharoen S

    更新日期:2015-10-01 00:00:00

  • Comparison of the Seeplex HPV4A ACE and the Cervista HPV assays for the detection of HPV in hybrid capture 2 positive media.

    abstract:OBJECTIVE:To validate the efficacy of Seeplex HPV4A ACE for the detection of high-risk (HR) human papillomavirus (HPV) and HPV 16 and/or HPV 18 genotypes as compared to the PCR method and the Cervista HPV assays in cervical swab samples. METHODS:Besides liquid-based cytology, additional 97 cervical swab samples were c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.1.5

    authors: Min KJ,So KA,Lee J,Hong HR,Hong JH,Lee JK,Kim AR

    更新日期:2012-01-01 00:00:00

  • Plasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia.

    abstract:OBJECTIVE:The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and the risk for cervical intraepithelial neoplasia (CIN) and cervical cancer. METHODS:Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patient...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.3.174

    authors: Lee SW,Lee SY,Lee SR,Ju W,Kim SC

    更新日期:2010-09-01 00:00:00

  • Gynecologic oncology group trials in uterine corpus malignancies: recent progress.

    abstract::The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced e...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2008.19.4.218

    authors: Miller DS,King LP

    更新日期:2008-12-01 00:00:00

  • Efficacy and fertility outcomes of levonorgestrel-releasing intra-uterine system treatment for patients with atypical complex hyperplasia or endometrial cancer: a retrospective study.

    abstract:OBJECTIVE:To investigate the efficacy of levonorgestrel-releasing intra-uterine system (LNG-IUS) treatment in patients affected by atypical complex hyperplasia/endometrial cancer (ACH/EC) wishing to preserve their fertility and to present fertility outcomes of those patients who actively tried to conceive. METHODS:Dat...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e57

    authors: Leone Roberti Maggiore U,Martinelli F,Dondi G,Bogani G,Chiappa V,Evangelista MT,Liberale V,Ditto A,Ferrero S,Raspagliesi F

    更新日期:2019-07-01 00:00:00

  • Performance of a low cost magnifying device, Magnivisualizer, versus colposcope for detection of pre-cancer and cancerous lesions of uterine cervix.

    abstract:OBJECTIVE:To assess the performance of a low cost magnifying device (Magnivisualizer) compared to a standard optical colposcope for detection of precancerous and cancerous lesions of the uterine cervix. METHODS:A total of 659 consecutive symptomatic women attending a gynecologic outpatient clinic underwent unaided vis...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.4.282

    authors: Singh V,Parashari A,Gupta S,Sodhani P,Sehgal A

    更新日期:2014-10-01 00:00:00

  • Robotic single site radical hysterectomy plus pelvic lymphadenectomy in gynecological cancers.

    abstract:OBJECTIVE:To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS:Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) F...

    journal_title:Journal of gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.3802/jgo.2018.29.e2

    authors: Vizza E,Chiofalo B,Cutillo G,Mancini E,Baiocco E,Zampa A,Bufalo A,Corrado G

    更新日期:2018-01-01 00:00:00