Abstract:
BACKGROUND:Radical prostatectomy (RP) can cure men with unfavorable intermediate- or high-risk prostate cancer (PC). However, some will experience short prostate-specific antigen (PSA) doubling time (PSADT) failure that requires additional treatment with increased toxicity. The present study investigated whether the greatest percentage of involved biopsy core length (GPC) can preoperatively identify men at risk of short PSADT failure. PATIENTS AND METHODS:A total of 503 men with biopsy-proven PC underwent RP at an academic institution from January 2005 to December 2008. Men with incomplete pathologic information, those who had received neoadjuvant or adjuvant hormonal therapy or chemotherapy, and those who had undergone adjuvant radiation therapy were excluded. The median follow-up period was 4.89 years (interquartile range, 1.97-5.68 years). A competing risk regression was used to assess whether an increasing GPC value was associated with an increased PSADT at < 10-month failure risk, adjusting for age, percentage of positive biopsy results, and risk group. RESULTS:Of the 402 men, 34 (8.46%) developed PSA failure, 17 (50.0%) of whom had a PSADT of < 10 months. An increasing GPC value was significantly associated with an increased PSADT of < 10-month failure risk (adjusted hazard ratio, 1.03; 95% confidence interval, 1.01-1.06; P = .015). Men with a GPC > 30% (median) versus ≤ 30% and unfavorable intermediate- or high-risk PC (P = .011), but not low or favorable intermediate-risk PC (P = .57), had a significantly greater incidence of PSADT < 10-month failure estimates (30% vs. 0% at 5 years). CONCLUSION:Men planning to undergo RP for unfavorable intermediate- or high-risk PC with a GPC of > 30% should be considered for randomized trials evaluating the effect on survival of the neoadjuvant use of treatment that extends survival in those with castrate-resistant metastatic PC.
journal_name
Clin Genitourin Cancerjournal_title
Clinical genitourinary cancerauthors
Cheney MD,Zhang D,Chen MH,Loffredo MJ,Richie JP,D'Amico AVdoi
10.1016/j.clgc.2015.02.012subject
Has Abstractpub_date
2015-08-01 00:00:00pages
338-343issue
4eissn
1558-7673issn
1938-0682pii
S1558-7673(15)00038-5journal_volume
13pub_type
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2016.03.021
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2018.09.024
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2017.01.024
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2017.05.016
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2019.09.003
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
pub_type: 临床试验,杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.3816/CGC.2007.n.006
更新日期:2007-03-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2013.11.005
更新日期:2014-06-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2014.09.006
更新日期:2015-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,评审
doi:10.1016/j.clgc.2013.04.009
更新日期:2013-09-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2019.12.006
更新日期:2020-06-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.3816/CGC.2006.n.006
更新日期:2006-03-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
doi:10.1016/j.clgc.2014.02.003
更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clgc.2019.09.014
更新日期:2020-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clgc.2018.09.013
更新日期:2019-02-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2020.01.007
更新日期:2020-10-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2017.08.011
更新日期:2017-09-05 00:00:00
abstract:BACKGROUND:Non-muscle-invasive bladder cancer (NMIBC) can be treated using transurethral resection (TUR), but high incidence of intravesical recurrence remains a clinical challenge. Single immediate postoperative instillation of chemotherapy (IPIOC) is controversial for NMIBC patients with intermediate recurrence risk....
journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2019.05.028
更新日期:2019-10-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2013.09.001
更新日期:2014-02-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2016.01.003
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Second-line systemic therapy for advanced urothelial carcinoma (UC) has substantial unmet needs, and current agents show dismal activity. Second-line trials of metastatic UC have used response rate (RR) and median progression-free survival (PFS) as primary endpoints, which may not reflect durable benefits. A ...
journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,meta分析
doi:10.1016/j.clgc.2013.09.002
更新日期:2014-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2015.07.004
更新日期:2015-12-01 00:00:00