Abstract：
:The purpose of this study was to investigate the genotoxic effects of chronic fluoride exposure on mammalian cells in vivo by use of the mouse bone-marrow micronucleus test and the sperm morphology methodology. Mice of genotype B6C3F1 were obtained at weaning and maintained on a low-fluoride diet (less than 0.2 ppm F) ad libitum throughout the experiment. The animals were randomly assigned to seven groups and given fluoride (as sodium fluoride) in concentrations ranging from 1.0 to 75 ppm in the drinking water. Negative (distilled water) and positive (cyclophosphamide) controls were included. After a 21-week treatment period, the animals were killed by cervical dislocation, and blood was obtained by cardiac puncture. Slides of femur marrow cells were prepared and blindly examined for the frequency of micronucleated polychromatic erythrocytes (MN-PCE). Slides of sperm from the cauda epididymides of the male mice were also prepared and similarly examined for morphological abnormalities. Weight of the testes was recorded, and the plasma, humeri, testes, and carcasses were saved for fluoride analyses. Analyses of bone and plasma fluoride confirmed the effective absorption of fluoride following ingestion. The frequency of MN-PCE, the count of abnormal sperm, and the weight of the testes for mice chronically exposed to fluoride, in doses ranging from approximately 0.3 to 23 mg/kg/day, were not significantly different from those of the negative control animals. The results of this study support the view that fluoride has no genotoxic effects.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Dunipace AJ,Zhang W,Noblitt TW,Li Y,Stookey GKdoi
10.1177/00220345890680111101subject
Has Abstractpub_date
1989-11-01 00:00:00pages
1525-8issue
11eissn
0022-0345issn
1544-0591journal_volume
68pub_type
杂志文章abstract：:The filtration and diffusion of tritiated water through dentin disks were measured ina split-chamber diffusion cell. The dentin had been cut with a diamond disk and the surfaces modified with a carbide fissure bur or diamond bur. Disks were given a secondary burnishing treatment with a blank bur or a modified blank bu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600061101
更新日期：1981-06-01 00:00:00
abstract：:Inflammatory conditions as they occur during periodontal disease often result in decreased alveolar bone levels and a loss of connective tissue homeostasis. Here we have focused on the effect of microRNA-138 (miR-138) as a potential regulator of periodontal stem cells as they affect homeostasis during inflammatory con...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515613043
更新日期：2016-02-01 00:00:00
abstract：:It was recently reported that human periapical cysts (hPCys), a commonly occurring odontogenic cystic lesion of inflammatory origin, contain mesenchymal stem cells (MSCs) with the capacity for self-renewal and multilineage differentiation. In this study, periapical inflammatory cysts were compared with dental pulp to ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515570316
更新日期：2015-06-01 00:00:00
abstract：:Dental plaque collected from the label aspect of the anterior dentition of children harbored Neisseria that synthesized an extracellular iodophilic polysaccharide (EIP) from sucrose. Gas chromatograms of fully-acetylated EIP derivatives indicated that glucose (97%) and galactose (3%) were the only monosaccharide const...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610050101
更新日期：1982-05-01 00:00:00
abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523784
更新日期：2014-04-01 00:00:00
abstract：:The aim of this study was to determine whether the parotid gland, like other salivary glands, produces blood group antigens. A post-embedding immunogold staining (IGS) method for ABH antigens was applied to osmicated and nonosmicated, routinely prepared specimens of normal human parotid glands. A and B antigens were n...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730021101
更新日期：1994-02-01 00:00:00
abstract：:The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory bi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512470691
更新日期：2013-02-01 00:00:00
abstract：:Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034508329273
更新日期：2009-02-01 00:00:00
abstract：:This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515573833
更新日期：2015-05-01 00:00:00
abstract：:We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457605500111011
更新日期：1976-01-01 00:00:00
abstract：:Breastfeeding is a powerful health-promoting behavior. A 2016 Lancet global collaboration to review the health implications of breastfeeding was among the first to consider oral health outcomes. While a role was suggested for breastfeeding in preventing malocclusion, caries was the only included disease condition unfa...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517738925
更新日期：2018-03-01 00:00:00
abstract：:Cyclic adenosine 3',5'-monophosphate (cAMP) concentrations and cellular distribution were studied in dental and periodontal tissues during tooth eruption in kittens. Although the mean levels of cAMP around developing teeth were similar in all the tissue samples, there were marked differences in cAMP stainability of ti...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560040801
更新日期：1977-04-01 00:00:00
abstract：:This systematic review and meta-analysis assessed the efficacy of lasers in reducing dentin hypersensitivity (DH) as compared with placebo or no treatment. Seven electronic databases and a manual search resulted in 2,538 unique publications. After selection, 13 studies were included in the meta-analysis. A CONSORT-bas...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/0022034513487212
更新日期：2013-06-01 00:00:00
abstract：:Dynamic changes of pulpal blood flow (PBF) and gingival blood flow (GBF) induced by intra-venous injection of two kinds of vasoactive drugs were observed in dogs by means of Laser Doppler Velocimetry. Intra-venous injection of norepinephrine caused PBF to increase, corresponding to the blood pressure (BP) increase, wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680050701
更新日期：1989-05-01 00:00:00
abstract：:Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509341243
更新日期：2009-08-01 00:00:00
abstract：:The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519853574
更新日期：2019-11-01 00:00:00
abstract：:Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515572190
更新日期：2015-04-01 00:00:00
abstract：:The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500214
更新日期：2006-02-01 00:00:00
abstract：:Apoptosis plays important roles in various stages of organogenesis. In this study, we hypothesized that apoptosis would play an important role in tooth morphogenesis. We examined the role of apoptosis in early tooth development by using a caspase inhibitor, z-VAD-fmk, concomitant with in vitro organ culture and tooth ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500610
更新日期：2006-06-01 00:00:00
abstract：:Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780070701
更新日期：1999-07-01 00:00:00
abstract：:Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacry...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400508
更新日期：2005-05-01 00:00:00
abstract：:Dental diseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable resident oral microbiome. It is known that frequent carbohydrate consumption or reduced saliva flow can lead to caries, and excessive plaque accumulation increases the risk of periodontal diseases. However, whe...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517742139
更新日期：2018-04-01 00:00:00
abstract：:Greater fluoride concentrations were obtained in enamel treated with phosphate/fluoride solutions than in that treated with TiF4 at similar pH's (1.0) and F concentrations (0.6M F and 1.6M F). However, fluoride solution without added phosphate at pH 1.0 and 1.6M F concentration produced lower fluoride concentrations i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580021001
更新日期：1979-02-01 00:00:00
abstract：:Using a pin-on-disc sliding-wear test apparatus, the wear behavior of a typical composite restorative vs. styli fashioned from human enamel, sintered alumina, and magnesium fluoride was examined. The rates of restorative wear were found to be identical, within the experimental error of the measurements, for tests usin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630062501
更新日期：1984-06-01 00:00:00
abstract：:Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510378425
更新日期：2010-12-01 00:00:00
abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516979
更新日期：2014-03-01 00:00:00
abstract：:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600818
更新日期：2007-08-01 00:00:00
abstract：:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700801
更新日期：2008-08-01 00:00:00
abstract：:Current knowledge regarding the sensitivity of the teeth to forces is based on psychophysical experiments that measured touch detection thresholds under static jaw conditions. It is not known whether jaw movements alter the perception of forces applied to the teeth, but, based on limb movement studies, it is hypothesi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510363101
更新日期：2010-04-01 00:00:00
abstract：:Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345970760100901
更新日期：1997-10-01 00:00:00
