Protective effects of N-acetylcysteine against hyperoxaluria induced mitochondrial dysfunction in male wistar rats.

abstract：:Beta-1,4-galactosyltransferase 1 (beta1,4-GT 1) is the key enzyme transferring galactose to the terminal N-acetylglucosamine (GlcNAc) forming Galbeta3-->4GlcNAc structure in the Golgi apparatus. In addition, it also serves as a cell adhesion molecule by recognizing and binding to terminal GlcNAc of glycoconjugates on ...

journal_title：Molecular and cellular biochemistry

authors： Zhang SW,Xu SL,Cai MM,Yan J,Zhu XY,Hu Y,Gu JX

更新日期：2001-05-01 00:00:00

abstract：:Abnormal angiogenesis underlies many pathological conditions and is critical for the growth and maintenance of various types of tumors, including hormone-dependent cancers. Since estrogens are potent carcinogens in humans and rodents, and are involved in regulating angiogenesis, this study was designed to examine the ...

journal_title：Molecular and cellular biochemistry

authors： Banerjee SK,Campbell DR,Weston AP,Banerjee DK

更新日期：1997-12-01 00:00:00

abstract：:Microtubule associated protein tau is considered to play roles in some types of human transmissible spongiform encephalopathies (TSE). In this study, the full-length and several truncated human tau proteins were expressed from E. coli and purified. Using GST pull down, co-immunoprecipitation assay and tau-coated ELISA...

journal_title：Molecular and cellular biochemistry

authors： Wang XF,Dong CF,Zhang J,Wan YZ,Li F,Huang YX,Han L,Shan B,Gao C,Han J,Dong XP

更新日期：2008-03-01 00:00:00

abstract：:Mucus hypersecretion is a major manifestation in patients with chronic inflammatory airway diseases, and MUC5AC protein is a major component of airway mucus. Earlier studies have demonstrated that neutrophil elastase (NE), a serine protease, mainly produced by neutrophils, stimulates the production of MUC5AC from airw...

journal_title：Molecular and cellular biochemistry

authors： Zhong T,Perelman JM,Kolosov VP,Zhou XD

更新日期：2011-12-01 00:00:00

abstract：:It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could not be cleaved in type I cells, could be effectively cleaved by recombinant active caspase-8 in vitro. The clea...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Qi L,Iwao A,Kihira K,Dida F,Song Z,Azuma E,Komada Y

更新日期：2009-11-01 00:00:00

abstract：:The aim of this study was to determine the effect of magnesium deficiency on small intestinal morphology and function. Rats were assigned to 4 groups and placed on magnesium sufficient or deficient diet for 1 or 3 weeks. Infiltration of neutrophils and mucosal injury were assessed in stained sections of small intestin...

journal_title：Molecular and cellular biochemistry

authors： Scanlan BJ,Tuft B,Elfrey JE,Smith A,Zhao A,Morimoto M,Chmielinska JJ,Tejero-Taldo MI,Mak IuT,Weglicki WB,Shea-Donohue T

更新日期：2007-12-01 00:00:00

abstract：:Elevated levels of triglycerides and very low density lipoproteins (VLDL) are biochemical markers of metabolic syndrome and diabetes. VLDL from hypertriglyceridemic or diabetic patients increased the generation of plasminogen activator inhibitor-1 (PAI-1) from cultured vascular endothelial cells (EC). Susceptibility o...

journal_title：Molecular and cellular biochemistry

authors： Zhao R,Ma X,Shen GX

更新日期：2008-10-01 00:00:00

abstract：:Diabetes-induced changes in glucose formation, intracellular and mitochondrial glutathione redox states as well as hydroxyl free radicals (HFR) generation have been investigated in rabbit kidney-cortex tubules. In contrast to renal tubules of control animals, diabetes-evoked increase in glucose formation in the presen...

journal_title：Molecular and cellular biochemistry

authors： Winiarska K,Drozak J,Wegrzynowicz M,Fraczyk T,Bryla J

更新日期：2004-06-01 00:00:00

abstract：:A high molecular weight protein has been isolated as a major polypeptide comprising 85% of the total extractable proteins in the fruit pericarp of the plant Impatiens balsamina. The protein has been purified to homogeneity following fractionation of the crude cell supernatant with ammonium sulphate, chromatography on ...

journal_title：Molecular and cellular biochemistry

authors： Pal M,Biswas S

更新日期：1994-01-26 00:00:00

abstract：:Guanylyl cyclases in eukaryotic unicells were biochemically investigated in the ciliates Paramecium and Tetrahymena, in the malaria parasite Plasmodium and in the ameboid Dictyostelium. In ciliates guanylyl cyclase activity is calcium-regulated suggesting a structural kinship to similarly regulated membrane-bound guan...

journal_title：Molecular and cellular biochemistry

authors： Linder JU,Schultz JE

更新日期：2002-01-01 00:00:00

abstract：:Liver cytosol from adrenalectomized rats was prebound for 2 hr at 4 degrees C with unlabeled 10(-5) M corticosterone. After treatment of cytosol with dextran-coated charcoal to remove free steroid, samples were incubated at 15-25 degrees C in the presence of 10 mM molybdate plus 5 mM dithiothreitol (followed by a 60 m...

journal_title：Molecular and cellular biochemistry

authors： Hubbard JR,Tanvir,Shirwany A,Kalimi M

更新日期：1985-01-01 00:00:00

abstract：:It has been recently shown that long-term thyroxine administration increases the tolerance of the heart to ischaemia. The present study investigated whether thyroxine induced cardioprotection involves alterations in the pattern of p38 mitogen activated protein kinase (p38MAPK) and c-Jun NH2-terminal kinases (JNKs) act...

journal_title：Molecular and cellular biochemistry

authors： Pantos C,Malliopoulou V,Paizis I,Moraitis P,Mourouzis I,Tzeis S,Karamanoli E,Cokkinos DD,Carageorgiou H,Varonos D,Cokkinos DV

更新日期：2003-01-01 00:00:00

abstract：:Hepatic stellate cells (HSCs), also referred to as Ito cells, perisinusiodal cells and fat-storing cells, have numerous vital functions. They are the main extracellular matrix-producing cells within the liver and are involved in the storage of retinol. HSCs are also known to secrete a number of liver mitogens. Current...

journal_title：Molecular and cellular biochemistry

authors： Riccalton-Banks L,Bhandari R,Fry J,Shakesheff KM

更新日期：2003-06-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isola...

journal_title：Molecular and cellular biochemistry

authors： Ghibu S,Lauzier B,Delemasure S,Amoureux S,Sicard P,Vergely C,Muresan A,Mogosan C,Rochette L

更新日期：2009-01-01 00:00:00

abstract：:The effect of anti-regucalcin monoclonal antibody on neutral phoshatase activity in rat liver cytosol was investigated. Phosphotyrosine, phosphoserine, and phosphothreonine were used as the substrate toward phosphatase assay. Liver cytosolic phosphatase activity with three phosphoaminoacids was significantly increased...

journal_title：Molecular and cellular biochemistry

authors： Omura M,Yamaguchi M

更新日期：1999-07-01 00:00:00

abstract：:We firstly characterized zinc uptake phenomenon across basolateral membrane vesicles (BLMVs) isolated from normal rat kidney. The process was found to be time, temperature, and substrate concentration dependent, and displayed saturability. Zn(2+) uptake was competitively inhibited in the presence of 2 mM Cd with Ki of...

journal_title：Molecular and cellular biochemistry

authors： Kaur J,Sharma N,Attri S,Gogia L,Prasad R

更新日期：2006-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a rapidly progressing, incurable cancer that frequently spreads to portal vein and lung. New insights are needed to identify therapeutic targets to prevent or retard HCC metastatic progression. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role in prec...

journal_title：Molecular and cellular biochemistry

authors： Shi X,Teng F

更新日期：2015-10-01 00:00:00

abstract：:Maitake mushroom has been reported to favorably influence hypertension and diabetes mellitus. The purpose of this study was to compare the effects of whole Maitake mushroom powder and two extracts designated as ether soluble (ES) and water soluble (WS) on Zucker fatty rats (ZFR), a model of insulin resistance, and on ...

journal_title：Molecular and cellular biochemistry

authors： Talpur NA,Echard BW,Fan AY,Jaffari O,Bagchi D,Preuss HG

更新日期：2002-08-01 00:00:00

abstract：:Five isoforms of CK2 may exist simultaneously in yeast cells: free catalytic subunits CK2α', CK2α and three holoenzymatic structures composed of αα'ββ', α(2)ββ' and α'(2)ββ'. Each isolated and purified form exhibits properties typical for CK2, but they differ in substrate specificity as well as in sensitivity to speci...

journal_title：Molecular and cellular biochemistry

authors： Janeczko M,Masłyk M,Szyszka R,Baier A

更新日期：2011-10-01 00:00:00

abstract：:Protein phosphorylation was investigated in [32P]-labeled cardiomyocytes isolated from adult rat heart ventricles. The beta-adrenergic stimulation (by isoproterenol, ISO) increased the phosphorylation of inhibitory subunit of troponin (TN-I), C-protein and phospholamban (PLN). Such stimulation was largely mediated by ...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Vo XT

更新日期：1995-08-01 00:00:00

abstract：:Methylxanthines are widely consumed because of their stimulating effect primarily on the central nervous system. Their diuretic and respiratory stimulant action is used in clinical medicine. L-Arginine metabolism in the brain is very important for normal brain function. In addition to brain protein synthesis, arginine...

journal_title：Molecular and cellular biochemistry

authors： Nikolic J,Bjelakovic G,Stojanovic I

更新日期：2003-02-01 00:00:00

abstract：:The treatment of obstructive sleep apnea-hypopnea syndrome targets the narrow anatomic structure of the upper airway (UA) and lacks an effective therapy for UA dilator muscle dysfunction. Long-term hypoxia can cause damage to UA dilator muscles and trigger a vicious cycle. We previously confirmed that hypoxia-inducibl...

journal_title：Molecular and cellular biochemistry

authors： Lu Y,Mao J,Han X,Zhang W,Li Y,Liu Y,Li Q

更新日期：2021-01-03 00:00:00

abstract：:We have previously demonstrated that Cationic Arginine-Rich Peptides (CARPs) and in particular poly-arginine-18 (R18; 18-mer of arginine) exhibit potent neuroprotective properties in both in vitro and in vivo neuronal injury models. Based on the current literature, there is a consensus that arginine residues by virtue...

journal_title：Molecular and cellular biochemistry

authors： MacDougall G,Anderton RS,Ouliel E,Gao J,Redmond SL,Knuckey NW,Meloni BP

更新日期：2020-01-01 00:00:00

abstract：:Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. Here we show that SNTB2 forms a complex with utrophin...

journal_title：Molecular and cellular biochemistry

authors： Krautbauer S,Neumeier M,Haberl EM,Pohl R,Feder S,Eisinger K,Rein-Fischboeck L,Buechler C

更新日期：2019-02-01 00:00:00

abstract：:In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistanc...

journal_title：Molecular and cellular biochemistry

authors： Balakumar M,Raji L,Prabhu D,Sathishkumar C,Prabu P,Mohan V,Balasubramanyam M

更新日期：2016-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been indicated as important signal mediators for many cell surface receptors. We previously demonstrated that ROS are generated by cross-linking surface receptor CD40 and consequently induce c-Jun N-terminal kinase activation and interleukin-6 secretion in murine B cells. In this stu...

journal_title：Molecular and cellular biochemistry

authors： Lee JR

更新日期：2003-10-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Efficient and secure drugs that can lower elevated plasma Lp(a) concentrations are currently lacking. Fibroblast growth factor-21 (FGF-21), a member of the FGFS super family, regulates glucose and lipid metabolism in hep...

journal_title：Molecular and cellular biochemistry

authors： Lin X,Li G,He X,Ma X,Zhang K,Zhang H,Zeng G,Wang Z

更新日期：2014-08-01 00:00:00

abstract：:In this article, we discuss our attempts to establish the existence in the cytoplasm of regulatory molecules involved in translational control. Our studies have revealed the presence of cAMP independent protein kinase in the free mRNP complex capable of phosphorylating a Mr = 38 000 polypeptide, also part of the same ...

journal_title：Molecular and cellular biochemistry

authors： Bag J,Sells BH

更新日期：1981-11-13 00:00:00

abstract：:Brain membrane lipid fatty acid composition and consequently membrane fluidity change with increasing age. Intracellular fatty acid binding proteins (FABPs) such as heart H-FABP and the brain specific B-FABP, detected by immunoblotting of brain tissue, are thought to be involved in fatty acid uptake, metabolism, and d...

journal_title：Molecular and cellular biochemistry

authors： Pu L,Igbavboa U,Wood WG,Roths JB,Kier AB,Spener F,Schroeder F

更新日期：1999-08-01 00:00:00