Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions.

Abstract:

:A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at low pH (pH 4.0 and pH 2.0), whereas no prominent quaternary structural changes were seen at 50 °C. Both oligomers and smaller oligomeric species exhibited abilities to suppress client aggregation at low pH and at 50 °C. These results suggest that sHsps may function in different modes in different stressed conditions.

journal_name

FEBS Open Bio

journal_title

FEBS open bio

authors

Liu L,Chen J,Yang B,Wang Y

doi

10.1016/j.fob.2015.02.006

subject

Has Abstract

pub_date

2015-03-05 00:00:00

pages

155-62

issn

2211-5463

pii

S2211-5463(15)00016-9

journal_volume

5

pub_type

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