Abstract:
:A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at low pH (pH 4.0 and pH 2.0), whereas no prominent quaternary structural changes were seen at 50 °C. Both oligomers and smaller oligomeric species exhibited abilities to suppress client aggregation at low pH and at 50 °C. These results suggest that sHsps may function in different modes in different stressed conditions.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Liu L,Chen J,Yang B,Wang Ydoi
10.1016/j.fob.2015.02.006subject
Has Abstractpub_date
2015-03-05 00:00:00pages
155-62issn
2211-5463pii
S2211-5463(15)00016-9journal_volume
5pub_type
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