Abstract:
BACKGROUND:Pogostemonis Herba, the dried aerial part of Pogostemon cablin Blanco, is a well-known materia medica in Asia that is widely used for syndrome of gastrointestinal dysfunctions. OBJECTIVE:This study was undertaken to examine whether Pogostemon cablin extract (PCe) might have any beneficial effect on hypoxia induced rabbit cardiomyocyte injury. MATERIALS AND METHODS:Isolated cardiomyocytes were divided into three groups and the changes of cell viability in cardiomyocytes of hypoxic and hypoxia/reoxygenation group were determined. The effect of PCe on reactive oxygen species (ROS) generation, intracellular formation of ROS was also measured by monitoring the 2',7'-dichlorofluorescein fluorescence. RESULTS:PCe effectively protected the cells against both the hypoxia and reoxygenation induced injury, and the protective effect of PCe is not mediated by interaction with adenosine triphosphate-sensitive K(+) channels. In the presence of PCe, production of ROS under chemical hypoxia was remarkably reduced which suggests that PCe might exert its effect as a ROS scavenger. CONCLUSION:The present study provides clear evidence for the beneficial effect of PCe on cardiomyocyte injury during hypoxia or reoxygenation following prolonged hypoxia.
journal_name
Pharmacogn Magjournal_title
Pharmacognosy magazineauthors
Lim CY,Kim BY,Lim SH,Cho SIdoi
10.4103/0973-1296.153084subject
Has Abstractpub_date
2015-04-01 00:00:00pages
311-9issue
42eissn
0973-1296issn
0976-4062pii
PM-11-311journal_volume
11pub_type
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journal_title:Pharmacognosy magazine
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journal_title:Pharmacognosy magazine
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