Abstract:
:Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR. Experimental models of diabetes were induced with streptozotocin (STZ) treatment or Insulin2 gene mutation (Akita) in mice. Protein expression and localization were examined by western blots (WB) and immunofluorescence (IF). mRNA expression was quantified by PCR array and real-time PCR. The activity of VEGFR1 signaling was blocked by a neutralizing antibody called MF1. Vascular leakage was evaluated by measuring the leakage of [(3)H]-mannitol tracer into the retina and the IF staining of albumin. VEGFR1 blockade significantly inhibited diabetes-related vascular leakage, leukocytes-endothelial cell (EC) adhesion (or retinal leukostasis), expression of intercellular adhesion molecule- (ICAM-) 1 protein, abnormal localization and degeneration of the tight junction protein zonula occludens- (ZO-) 1, and the cell adhesion protein vascular endothelial (VE) cadherin. In addition, VEGFR1 blockade interfered with the gene expression of 10 new cytokines and chemokines: cxcl10, il10, ccl8, il1f6, cxcl15, ccl4, il13, ccl6, casp1, and ccr5. These results suggest that VEGFR1 mediates complications of DR and targeting this signaling pathway represents a potential therapeutic strategy for the prevention and treatment of DR.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
He J,Wang H,Liu Y,Li W,Kim D,Huang Hdoi
10.1155/2015/605946subject
Has Abstractpub_date
2015-01-01 00:00:00pages
605946eissn
2090-004Xissn
2090-0058journal_volume
2015pub_type
杂志文章abstract:Purpose:To report the long-term follow-up results of posterior segment intraocular foreign body (IOFB) removal in children and to determine the prognostic factors for visual outcome. Methods:Design: retrospective, noncomparative, interventional case series; a single tertiary care center study. Participants or samples:...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5861043
更新日期:2018-06-25 00:00:00
abstract:Purpose:To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods:We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in bo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7936205
更新日期:2020-07-04 00:00:00
abstract:Purpose:To examine the morphological changes in the meibomian glands of patients with keratoconus as well as to study the relationship between these changes in the morphology and several tear film parameters. Methods:Examination of the meibomian gland (MG) of 300 keratoconus patients presenting to the center using inf...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2965872
更新日期:2019-06-02 00:00:00
abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1917093
更新日期:2016-01-01 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9028483
更新日期:2019-02-24 00:00:00
abstract:Purpose:To evaluate contrast sensitivity (CS) changes in acute central serous chorioretinopathy (CSC). Methods:Visual acuity (VA), CS, and subretinal fluid (SRF) were evaluated monthly for 6 months. Treatment was considered at 3 months in case of persistent SRF. Results:Twelve of 20 eyes (60%) had spontaneous SRF res...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/9053932
更新日期:2017-01-01 00:00:00
abstract:Purpose:Evaluation of the indications, anatomical and functional results, and complications of total penetrating keratoplasty (TPK) in disorders involving whole cornea. Materials and Methods:We analyzed outcomes of the surgical treatment of 47 eyes of 46 patients that underwent TPK. Indications were infectious keratit...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9580292
更新日期:2018-04-19 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6354025
更新日期:2017-01-01 00:00:00
abstract::Purpose. To present a series of retinal disease cases that were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality. Methods. The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD)...
journal_title:Journal of ophthalmology
pub_type:
doi:10.1155/2011/764183
更新日期:2011-01-01 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1319628
更新日期:2018-03-07 00:00:00
abstract:Purpose:Glaucoma is the leading cause of irreversible blindness throughout the world. The pathogenesis of glaucoma is complex, and neuroprotection is a crucial aspect of therapy. High concentrations of extracellular glutamate are toxic to the optic nerve. The glutamate-aspartate transporter (GLAST) in retinal Müller ce...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6128470
更新日期:2018-10-31 00:00:00
abstract::Purpose. This study aims to explore the safety and efficacy of a novel treatment-intense pulsed light (IPL) in MGD eyes. Methods. This study is a prospective and open label study. Forty eyes of 40 MGD patients were recruited in the study and received 4 consecutive IPL treatments on day 1, day 15, day 45, and day 75. T...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1910694
更新日期:2016-01-01 00:00:00
abstract::We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/3438041
更新日期:2017-01-01 00:00:00
abstract:Purpose:To explore whether bandage lenses could be a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients in terms of infection prevention, ocular impacts, and patient satisfaction. Methods:Patients who underwent cataract surgery were randomly divided into the eye patch g...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1493967
更新日期:2018-05-15 00:00:00
abstract::Purpose. To evaluate visual and safety outcomes of 23-gauge (G) pars plana vitrectomy (PPV) with application of perfluorocarbon liquid (PFCL) for intraoperative protection of the macula during intraocular foreign body (IOFB) removal. Methods. Retrospective study of 42 patients who underwent 23 G PPV for IOFB removal f...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6232151
更新日期:2017-01-01 00:00:00
abstract::This study is for identifying systemic factors correlating with intraocular levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in diabetic retinopathy. Forty-two consecutive patients undergoing pars plana vitrectomy (PPV) for PDR were included in this cross-sectional study. The aqueous humor ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/4831967
更新日期:2019-07-17 00:00:00
abstract::Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9721085
更新日期:2019-07-02 00:00:00
abstract:Purpose:To compare the efficacy of passive drainage (PD) and repeated fluid-air (FA) exchange for removing emulsified silicone oil (SO) droplets. Methods:Twenty rhegmatogenous retinal detachment (RRD) patients who underwent primary pars plana vitrectomy (PPV) with SO tamponade were randomly and evenly divided into two...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8184607
更新日期:2020-07-04 00:00:00
abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5320105
更新日期:2016-01-01 00:00:00
abstract:Purpose:To investigate the association between regional solar radiation and myopia occurrence in South Korean children. Materials and Methods:A population-based cross-sectional study using data of 1218 children aged 7-9 years from the Korea National Health and Nutritional Examination Survey was conducted from January ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7643850
更新日期:2019-06-10 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/4165706
更新日期:2017-01-01 00:00:00
abstract:Introduction:Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specia...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/3985865
更新日期:2019-07-01 00:00:00
abstract:Purpose:To evaluate intraoperative complications and utilization of adjunctive devices between microscope and intracameral illuminations during cataract surgery in the elderly over 75 years. Design:A retrospective, consecutive, interventional case series Participants. Two hundred eighty-six eyes of 184 patients older ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1594152
更新日期:2019-01-10 00:00:00
abstract:Purpose:To evaluate the clinical classification and characteristics of hereditary optic neuropathy patients in a single center in China. Method:Retrospective case study. Patients diagnosed with hereditary optic neuropathy between January 2014 and December 2015 in the neuro-ophthalmology division in Shanghai Eye and EN...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6186052
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the surgical outcome of Ahmed glaucoma valve (AGV) implantation according to the angle status in neovascular glaucoma (NVG) eyes. MATERIALS AND METHODS:This retrospective study included 70 NVG patients who underwent AGV implanta...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7672485
更新日期:2017-01-01 00:00:00
abstract:Purpose:To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods:Consecutive pati...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/3751702
更新日期:2018-02-04 00:00:00
abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/397495
更新日期:2015-01-01 00:00:00
abstract::Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/923941
更新日期:2015-01-01 00:00:00
abstract:Purpose:To determine the effectiveness and safety of selective laser trabeculoplasty (SLT) in young patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Methods:This was a retrospective clinical study. Fifty-six eyes from 56 young (age ≤ 40 y) patients with POAG or OHT treated with SLT were ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/5742832
更新日期:2020-06-09 00:00:00
abstract::Ciliopathies encompass a group of genetic disorders characterized by defects in the formation, maintenance, or function of cilia. Retinitis pigmentosa (RP) is frequently one of the clinical features presented in diverse ciliopathies. RP is a heterogeneous group of inherited retinal disorders, characterized by the deat...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2015/414781
更新日期:2015-01-01 00:00:00