The evaluation of bone metabolism in children with renal transplantation.

Abstract:

:This study aims to evaluate BMD and bone biomarkers and to investigate the effects of immunosuppressives on bone disease after RTx. Thirty-three RTR aged 16.7 ± 3.7 yr and healthy controls (n = 32) were enrolled. There was no difference between pre-RTx BMD and BMD at the time of study (45.9 ± 30.9 months after RTx), while both values were lower than controls (p < 0.01 and p < 0.05, respectively). Worst BMD scores were obtained at sixth month after RTx (-0.2 ± 0.9) and best at fourth year (1.4 ± 1.3). 25-hydroxy-(OH) vitamin D and OPG were higher in RTR (p < 0.001). BMD z scores negatively correlated with OPG and cumulative CS doses at the time of study (r = -0.344, p < 0.05 and r = -0.371, p < 0.05, respectively). Regression analysis revealed OPG as the only predictor of BMD (β -0.78, 95% CI -0.004 to -0.013, p < 0.001). The increase in OPG, a significant predictor of BMD, could either be secondary to graft dysfunction or for protection against bone loss. CS doses should be minimized to avoid their untoward effects on bone metabolism.

journal_name

Pediatr Transplant

authors

Büyükkaragöz B,Bakkaloglu SA,Kandur Y,Isiyel E,Akcaboy M,Buyan N,Hasanoglu E

doi

10.1111/petr.12469

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

351-7

issue

4

eissn

1397-3142

issn

1399-3046

journal_volume

19

pub_type

杂志文章
  • Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation.

    abstract::CNL is a rare myeloproliferative disorder frequently seen in older adults. A significant proportion of patients show progression to AML. Here, we report the case of a patient with FA who was monitored for leukopenia but who developed leukocytosis during the follow-up and was diagnosed with CNL probably after an acquir...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13199

    authors: Uygun V,Daloğlu H,Öztürkmen S,Karasu G,Avcı Z,Yeşilipek A

    更新日期:2018-08-01 00:00:00

  • Exploring the potential for online peer support mentorship: Perspectives of pediatric solid organ transplant patients.

    abstract:OBJECTIVE:Self-management for patients who have undergone solid organ transplantation is demanding and a challenge for adolescents transitioning into adult-oriented healthcare systems. This study explores whether adolescent and young adult solid organ transplant patients support the use of online peer support programs ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13900

    authors: Anthony SJ,Young K,Ghent E,Gold A,Martin K,Solomon M,Teoh CW,Stinson J

    更新日期:2020-11-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2001.00035.x

    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • Does renal transplant in children with LUTD improve their bladder function?

    abstract::Much is still unknown about LUT function after receiving renal graft. Graft function was the main focus of different studies discussing the same issue. However, these studies ignored the effects of the graft on lower tract function and more demand for bladder cycling and growth of the child. Therefore, we aimed at eva...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13735

    authors: Aboulela W,Fawzy AM,Abdelmawla MA,Salah DM,Eldin MS,Mohamed Anwar AZ,El Ghoneimy M,Shouman AM,Shoukry AI,Bazaraa H,Tawfiek ER,Fadel F,Badawy H,Morsi HA,Ghoneima W

    更新日期:2020-09-01 00:00:00

  • Arterioportal fistulae following segmental liver transplantation in a child.

    abstract::We report a case of arterio-portal fistulae in a 12-month-old-child following a segmental liver transplantation. The fistula, probably the result of mass ligature of a vascular pedicle during back table allograft reduction, is to our knowledge the first such case reported. Diagnosed on the third post-operative day, th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-2-00002.x

    authors: Mieles LA,Waldman D,Orloff MS

    更新日期:2002-10-01 00:00:00

  • Cardiac magnetic resonance imaging in children with chronic kidney disease and renal transplantation.

    abstract::CV disease is the major cause of death in patients with CKD. Recently, CMR imaging emerges as a complementary method providing advantages in cardiac assessment; however, data on CMR in pediatric CKD are scarce. We performed CMR in 15 children: two with CKD, six on peritoneal dialysis, seven on hemodialysis, and in 18 ...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-3046.2012.01672.x

    authors: Schaefer B,Rusai K,Toth A,Pasti K,Ujszaszi A,Kreko M,Horvath E,Sallay P,Reusz GS,Merkely B,Tulassay T,Szabo AJ

    更新日期:2012-06-01 00:00:00

  • Liver failure and x-linked immunodeficiency type 47.

    abstract::Patients with defects in the ATP6AP1 gene have rarely been described. ATP6AP1-related disorders are a subtype of CDG, which result in enzyme deficiencies affecting multiple organ systems ranging from mild to life-threatening. Of the 13 patients described, all had hepatopathy, but this is the first case to be successfu...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13808

    authors: Gumm AJ,Basel DG,Thakrar P,Suchi M,Telega G

    更新日期:2020-12-01 00:00:00

  • Post-transplantation growth among pediatric recipients of liver transplantation.

    abstract::Improving a patient's quality-of-life (QOL) post-liver transplantation is of great importance. An aspect of improved QOL is the restoration of normal growth patterns in pediatric patients. To describe the post-transplantation growth patterns of 72 children included in the National Institute of Diabetes and Digestive a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00326.x

    authors: Evans IV,Belle SH,Wei Y,Penovich C,Ruppert K,Detre KM,National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Team.

    更新日期:2005-08-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • Surgical treatment of primary liver tumors in children: outcomes analysis of resection and transplantation in the SEER database.

    abstract::Adjusted survival outcomes following hepatic resection and transplantation for pediatric liver tumors have not been compared. To address this question, we conducted a retrospective cohort study using the SEER registry. While SEER lacks certain specifics regarding staging, chemotherapy, comorbidities, and recurrence, i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12144

    authors: McAteer JP,Goldin AB,Healey PJ,Gow KW

    更新日期:2013-12-01 00:00:00

  • Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation.

    abstract::We studied restoration of the coagulation and fibrinolysis system in pediatric patients following liver transplantation and biomarkers of blood coagulation and fibrinolysis for suspecting the occurrence of acute cellular rejection. Coagulation activity recovered rapidly within two days following transplantation, but i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01248.x

    authors: Mimuro J,Mizuta K,Kawano Y,Hishikawa S,Hamano A,Kashiwakura Y,Ishiwata A,Ohmori T,Madoiwa S,Kawarasaki H,Sakata Y

    更新日期:2010-05-01 00:00:00

  • Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.

    abstract:UNLABELLED:Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12520

    authors: Bolton SM,Campbell KM,Kukreja M,Kohli R

    更新日期:2015-08-01 00:00:00

  • Subcutaneous IgG replacement after pediatric SCT.

    abstract::Hypogammaglobulinemia is common after pediatric SCT and IgG replacement is recommended. Some children will have a prolonged hypogammaglobulinemia but may have poor venous access which impedes further iv IgG replacement. In primary antibody deficiencies, sc IgG replacement, performed by parents at home, has been shown ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01783.x

    authors: Sundin M,Nordin K,Jostemyr Y,Winiarski J

    更新日期:2012-12-01 00:00:00

  • Bilateral lung transplant in Gauchers type-1 disease.

    abstract::We report a case of a patient who received a bilateral lung transplant for end-stage lung disease secondary to Gauchers type-1 disease with no evidence of recurrence of the disease in the transplanted lung. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00251.x

    authors: Rao AR,Parakininkas D,Hintermeyer M,Segura AD,Rice TB

    更新日期:2005-04-01 00:00:00

  • Living donor liver transplantation for hepatoblastoma with Beckwith-Wiedemann syndrome.

    abstract::BWS is one of the most well-known somatic overgrowth syndromes, which is characterized by macroglossia, organomegaly, abdominal wall defects, and predisposition to embryonal tumors, such as Wilms' tumor, hepatoblastoma, and adrenocortical carcinoma. We report a case of BWS in a girl with unresectable hepatoblastoma, w...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01198.x

    authors: Sasaki K,Kasahara M,Fukuda A,Shigeta T,Tanaka H,Nakagawa S,Mitsui K,Harada R,Nakagawa A

    更新日期:2010-11-01 00:00:00

  • Preemptive plasmapheresis and recurrence of focal segmental glomerulosclerosis in pediatric renal transplantation.

    abstract::  FSGS has a high recurrence rate after renal transplantation. To examine the effects of the use of preemptive and post-transplant PP on recurrence and graft outcome, we conducted a retrospective study on 34 pediatric patients (mean age 13±5 yr) with biopsy-proven pretransplant FSGS and who underwent a renal transplan...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01478.x

    authors: Gonzalez E,Ettenger R,Rianthavorn P,Tsai E,Malekzadeh M

    更新日期:2011-08-01 00:00:00

  • Tacrolimus withdrawal and conversion to sirolimus at three months post-pediatric renal transplantation.

    abstract:UNLABELLED:Nephrotoxicity caused by CNI may adversely affect long-term graft outcomes. For this reason, we have adopted a protocol for withdrawing TAC and converting to SRL at three months post-renal transplantation. All recipients received basiliximab induction and TAC, MMF, and prednisone. Patients without acute reje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00906.x

    authors: Hymes LC,Warshaw BL,Amaral SG,Greenbaum LA

    更新日期:2008-11-01 00:00:00

  • Health-related quality of life changes following renal transplantation in children.

    abstract:BACKGROUND:Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL. METHODS:We performed a retrospective study using the PedsQL3.0ESRD module during dialysis and at 3 and 12 months following kidney transplant in 56 recipients. For the enti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13333

    authors: Wightman A,Bradford MC,Smith J

    更新日期:2019-03-01 00:00:00

  • Pleural disease in patients undergoing lung transplantation for cystic fibrosis.

    abstract::Cystic fibrosis (CF) is associated with varying degrees of pleural inflammatory reaction that occurs as a result of chronic pulmonary infections and intervention to pleural space. The amount of pleural reaction is associated with the difficulty involved when performing the pneumonectomy at the time of lung replacement...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Dosanjh A,Jones L,Yuh D,Robbins RC

    更新日期:1998-11-01 00:00:00

  • Grading acute graft-versus-host disease: time to reconsider.

    abstract::Acute graft-versus-host disease (GVHD) is a common and serious complication of allogeneic blood and marrow transplantation. Acute GVHD is commonly graded according to modified Glucksberg criteria. There is considerable within-grade heterogeneity with different patterns of skin, liver, or gut involvement. In this comme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12433

    authors: Goyal RK,Goyal M,Sankaranarayan K

    更新日期:2015-05-01 00:00:00

  • Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipients.

    abstract::Despite the introduction of a variety of new immunosuppressive agents, cyclosporine A (CsA) has maintained a strong position in pediatric transplantation (Tx). Post-Tx dosing with CsA is a challenging task because of the narrow therapeutic window of the drug, the great individual variability of metabolism and the lack...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00025.x

    authors: Seikku P,Hoppu K,Jalanko H,Holmberg C

    更新日期:2003-04-01 00:00:00

  • Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

    abstract:BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS da...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13826

    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

    更新日期:2020-12-01 00:00:00

  • Lipoprotein profile changes in children after renal transplantation in the modern immunosuppression era.

    abstract::There are little data on prevalence of dyslipidemia in pediatric kidney TX recipients in the modern IS era. LP profiles of 38 TX recipients receiving triple IS with MMF, prednisone, and tacrolimus were compared with those of 11 children on HD using mixed model multiple linear regression analysis of repeated measures a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00905.x

    authors: Sgambat K,He J,McCarter RJ,Moudgil A

    更新日期:2008-11-01 00:00:00

  • Liver transplantation for hepatoblastoma: indications and contraindications in the modern era.

    abstract::In the past 20 yr, a dramatic improvement has been achieved in the outcome of children with hepatoblastoma by combining cisplatin based chemotherapy and surgery. Treatment of patients in the USA is an exception to the rule that all patients should receive neoadjuvant chemotherapy. It is paramount that surgical resecti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00354.x

    authors: Otte JB,de Ville de Goyet J,Reding R

    更新日期:2005-10-01 00:00:00

  • Minimum mycophenolic acid levels are associated with donor-specific antibody formation.

    abstract::Although de novo DSA are associated with inferior graft survival, there are no effective strategies to prevent their formation. Underexposure to MPA (prodrug: MMF) also contributes to rejection rates early after transplantation, but the effect of this phenomenon on the formation of DSA long-term post-transplantation i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12637

    authors: Filler G,Todorova EK,Bax K,Alvarez-Elías AC,Huang SH,Kobrzynski MC

    更新日期:2016-02-01 00:00:00

  • Imaging in pediatric renal transplantation.

    abstract::Renal transplantation is the therapy of choice in children with ESKD. Radiological investigations are required in both pre- and post-transplant assessment, although there is paucity of both consensus-based statements and evidence-based imaging guidelines in pediatric renal transplantation. The phases of pediatric ESKD...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12885

    authors: Damasio MB,Ording Muller LS,Piaggio G,Marks SD,Riccabona M

    更新日期:2017-05-01 00:00:00

  • Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

    abstract::Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children pos...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13420

    authors: Flynn E,Huang JY,Hardikar W,Herd L,Hodgson A,Monagle P

    更新日期:2019-06-01 00:00:00

  • C2 blood concentrations of orally administered cyclosporine in pediatric liver graft recipients with a body weight below 10 kg.

    abstract::Pharmacokinetic studies in adult and pediatric liver transplant recipients have shown that the C(2) monitoring is superior to the traditional determination of CsA trough levels (C(0)) as an estimate of CsA exposure. However, target reference values for C(2) in very small infants have not been established yet. The obje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00138.x

    authors: Ganschow R,Richter A,Grabhorn E,Schulz A,von Hugo A,Mir TS,Broering DC,Rogiers X,Hinrichs B,Burdelski M

    更新日期:2004-04-01 00:00:00

  • Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: clinical outcomes in a context of specialized oral care using low-level laser therapy.

    abstract::OM is a painful inflammatory condition of the oral mucosa, derived from the toxic effects of chemotherapy and radiotherapy. High OM severity is frequently present in HSCT pediatric patients, who exhibit multiple painful ulcers that limit their mastication and swallowing, leading to poor nutritional status. Few studies...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12440

    authors: Eduardo Fde P,Bezinelli LM,de Carvalho DL,Lopes RM,Fernandes JF,Brumatti M,Vince CS,de Azambuja AM,Vogel C,Hamerschlak N,Correa L

    更新日期:2015-05-01 00:00:00

  • Living donor lobar lung transplantation: the pediatric experience.

    abstract::Living donor (LD) lobar lung transplantation is now an accepted alternative to cadaveric lung transplantation in selected patients with end-stage lung disease. This study reviews the Childrens Hospital Los Angeles LD experience of 17 patients (mean 13.2 +/- 2.7 yrs; range 9.3-18.5 yrs). 12 LD patients had end-stage cy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Woo MS,MacLaughlin EF,Horn MV,Wong PC,Rowland JM,Barr ML,Starnes VA

    更新日期:1998-08-01 00:00:00