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Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

Abstract：

:Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kettle JG,Ballard P,Bardelle C,Cockerill M,Colclough N,Critchlow SE,Debreczeni J,Fairley G,Fillery S,Graham MA,Goodwin L,Guichard S,Hudson K,Ward RA,Whittaker D

doi

10.1021/acs.jmedchem.5b00098

subject

Has Abstract

pub_date

2015-03-26 00:00:00

pages

2834-44

issue

6

eissn

0022-2623

issn

1520-4804

journal_volume

58

pub_type

杂志文章

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