Racial differences in iron measures and outcomes observed during an iron reduction trial in peripheral arterial disease.

Abstract:

:Elevated body iron (ferritin) levels may contribute to adverse health outcomes. Racial differences in iron measures and clinical outcomes were observed during an iron reduction trial in peripheral arterial disease. At entry, Black compared with White participants had higher ferritin and lower red cell measures, as well as differing ferritin and percent transferrin saturation (%TS) responses, and HDL/LDL ratios associated with statin use. Lower hematocrit levels during follow-up resulted in fewer phlebotomies, less iron unloading (ferritin reduction, p=.035) and 32% less iron removed in Black compared with White participants randomized to iron reduction. Improved primary (all-cause mortality) and secondary (death plus non-fatal myocardial infarction and stroke) outcomes among White participants correlated with lower ferritin levels (p=.005 and p=.053, respectively) and higher %TS levels (p<.001 and p=.001 respectively), associations not observed in Black participants. Variant iron homeostasis contributory to racial health disparities warrants personalized intervention strategies and race-specific clinical trial design.

authors

Zacharski LR,Shamayeva G,Chow BK,DePalma RG

doi

10.1353/hpu.2015.0026

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

243-59

issue

1

eissn

1049-2089

issn

1548-6869

pii

S1548686915100202

journal_volume

26

pub_type

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