Safety and efficacy of intravenous colistin in children.

Abstract:

OBJECTIVE:To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium. METHODS:This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE criteria. RESULTS:Out of 68 children, 52 (76.5%) survived. There were three children with evidence of acute kidney injury and none had neurotoxicity. Serum creatinine significantly decreased at 48 h and at end of treatment, from that at beginning of therapy (P=0.007). CONCLUSIONS:Colistimethate sodium is effective against carbapenem-resistant Gram-negative bacteria, and is safe in children.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Kumar PP,Giri SR,Shaikh FA,Panigrahy N,Chirla D

doi

10.1007/s13312-015-0586-1

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

129-30

issue

2

eissn

0019-6061

issn

0974-7559

journal_volume

52

pub_type

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