Abstract：
:Fifty years ago, in 1964, our understanding of the immune system was very rudimentary. Gell and Coombs had just described classes of hypersensitivity reactions, and Bruton had described and commenced immunoglobulin replacement in agammaglobulinaemia. The distinction between T and B cells was not identified and characterised until the 1960s and 1970s. This was followed by increasing recognition of T and B cell collaboration in immune responses and identification of significant immunodeficiencies. CD4 and CD8 T cells were only recognised in the 1970s and 1980s. We now know of five CD4 subsets; dysfunction of each is associated with different disorders. By 2014, advances in technology have enabled identification of the genetic basis of over 240 primary immunodeficiencies. Research into the gut microbiome and vitamin D holds promise for the understanding, treatment and prevention of autoimmune and allergic diseases. Immunoglobulin preparations for the treatment of antibody deficiencies improved with the development of preparations for intravenous then subcutaneous administration, giving patients choice and the ability for home-based treatment, especially if experiencing infusion associated adverse effects. Newborn screening for severe combined immunodeficiency is a reality. Improvements in haemopoietic stem cell transplantation and now gene therapy, albeit still only available in the research setting, are improving long-term survival in primary immunodeficiencies. Biologic therapeutic agents are improving the control of autoimmune disease but potentially leading to secondary immunodeficiency, increasing the risk of opportunistic infection and malignancy. It is an exciting time.
journal_name
J Paediatr Child Healthjournal_title
Journal of paediatrics and child healthauthors
Wong Mdoi
10.1111/jpc.12834subject
Has Abstractpub_date
2015-02-01 00:00:00pages
135-9issue
2eissn
1034-4810issn
1440-1754journal_volume
51pub_type
历史文章,杂志文章,评审abstract：:A retrospective study of 9070 female infants born at the Foothills Provincial Hospital was conducted to determine the incidence of labial fusion at birth. A prospective study was also conducted on 1970 female patients assessed through a paediatric outpatient clinic to determine the incidence of labial fusion in this p...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1993.tb00495.x
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVE:To analyse hospital readmissions to 1 year in infants < 33 weeks' gestation. STUDY DESIGN:Cohort of very preterm infants born in Western Australia. METHODS:Parental social class, history of asthma, race, gestational age, birthweight, sex, severity of respiratory disease and oxygen requirement at 28 days chr...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.1999.00308.x
更新日期：1999-04-01 00:00:00
abstract：AIM:To examine the use of high frequency ventilation (HFV) to treat newborn infants in Australia and New Zealand and the associated complications and outcomes. METHODS:Data for all infants receiving HFV were collected from the 28 neonatal intensive care units contributing to the Australian and New Zealand Neonatal Net...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2007.01036.x
更新日期：2007-03-01 00:00:00
abstract：AIM:This study compared the personality profiles of children with sighing dyspnoea with healthy children and tested the hypothesis of heightened anxiety scores in sighing dyspnoeic subjects using the Childhood Behavior Check List for Ages 4 to 18 (CBCL/4-18). The pulmonary function tests of these two groups of children...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2007.01059.x
更新日期：2007-04-01 00:00:00
abstract：:We describe three infants born to mothers with poorly controlled Graves' disease, who developed transient central hypothyroidism in the immediate postnatal period. Suppression of the fetal pituitary-thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months pos...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2002.00741.x
更新日期：2002-04-01 00:00:00
abstract：:Turner syndrome (TS) affects approximately 1 in 2000 liveborn girls. It is a common cause of short stature and is often, but not universally, associated with characteristic dysmorphic features and ovarian dysgenesis. Genotype/phenotype correlation in TS is generally poor and girls with TS may occasionally have normal ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2007.01219.x
更新日期：2007-11-01 00:00:00
abstract：AIM:The aim of this study is to measure objectively and accurately the physical activity (PA) patterns in Spanish children and adolescents according to their obesity status, gender and age groups. METHODS:A sample of 487 children and 274 adolescents from the European Youth Heart Study participated in the study. The va...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12442
更新日期：2013-11-01 00:00:00
abstract：:Infantile botulism classically presents with a triad of clinical features: Bulbar palsies (slow/absent pupil response) Alert Absent fever Other common features are: Constipation, ptosis and poor feeding The diagnosis is a clinical one, confirmed by EMG and by testing stool for the organism, C. botulinum, or its toxin....
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2000.00595.x
更新日期：2000-12-01 00:00:00
abstract：:Lower urinary tract symptoms, particularly urgency, frequency and incontinence are common in school-aged children but are often overlooked. They may cause considerable physical, social and psychological difficulties to children and their families, and usually are manifestations of underlying non-neurogenic voiding dis...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1754.2011.02216.x
更新日期：2012-02-01 00:00:00
abstract：:The following principles are now clearly defined in the management of children with developmental delay: (1) Multidisciplinary teams are more effective than individual therapeutic approaches. (2) The whole development of the child needs to be considered rather than a single deficient area alone. (3) Home-based program...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1754.1992.tb02688.x
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVES:Although enormous effort has been focused over the past two decades on examining the potential adverse effects of exposure to environmental lead on human health, there has been a debate over the persistence and dynamic pattern of these effects. METHODOLOGY:Articles relevant to this issue which were publishe...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1754.1998.00187.x
更新日期：1998-04-01 00:00:00
abstract：:We report the case of a 7 year old girl who presented to the Children's Emergency Department with a 6 week history of bilateral facial and neck swelling. She had felt generally unwell, tired, with a recent onset of dry cough, and had presented multiple times to her general practitioner (GP) who after initially unsucce...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2010.01741.x
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To identify whether obstetric and perinatal factors are independent predictors of child behaviour at 5 years. METHODOLOGY:The Mater University Study of Pregnancy (MUSP) is a prospective cohort study of 8556 mothers enrolled in early pregnancy. The relationship of obstetric and perinatal factors, maternal lif...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1997.tb01658.x
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:Children referred for persistent cough were evaluated for the referring and final diagnosis, and the extent of the use of medications prior to referral and the side effects encountered. METHODS:Data on children seen by respiratory paediatricians for persistent cough (> or =4 weeks) in a tertiary respiratory ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2002.00045.x
更新日期：2002-12-01 00:00:00
abstract：:Ultrasound techniques have been developed since the past century and are becoming more useful in different areas of medical knowledge. More recently, lung ultrasound gained importance throughout artefacts analysis to help clinical evaluation at bedside and became subject of interest in the paediatric intensive care an...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/jpc.14067
更新日期：2018-09-01 00:00:00
abstract：:Legal and clinical complexities surrounding consent to medical treatment for trans and gender diverse (TGD) youth in Australia continue to develop. New Australian Standards of Care and Treatment Guidelines have also introduced substantial clinical developments. Significant changes to legal principles from court decisi...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.15181
更新日期：2020-12-01 00:00:00
abstract：:Australia requires a national plan, similar to plans developed internationally, to address the impacts of rare diseases on individuals, the community and health services. Rare diseases often present in childhood, many are chronic, some life threatening and others associated with significant disability. However, diagno...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2009.01608.x
更新日期：2010-01-01 00:00:00
abstract：AIM:This study aims to describe the phenotypic and genotypic characteristics of 45 Australian patients with tuberous sclerosis complex (TSC), to assess risk factors for intellectual disability, to compare patients with TSC1 and TSC2 mutations and to assess adherence to surveillance recommendations. METHODS:Phenotypic ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2011.02038.x
更新日期：2011-10-01 00:00:00
abstract：:Malaria is one of the greatest killers of children in the world. Treatment is available, but there are problems with affordability, availability, accessibility and increasing drug resistance. A new regime, intermittent preventive treatment in infants (IPTi) shows promise. It involves giving a treatment course of antim...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1754.2007.01105.x
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:To explore the opinions of non-tertiary obstetricians towards the care and outcome of extremely premature infants. METHODS:A structured questionnaire was mailed nationally to 232 obstetricians affiliated to maternity facilities with Level II nurseries. RESULTS:The overall response rate was 75% (n = 174) aft...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2003.00187.x
更新日期：2003-08-01 00:00:00
abstract：AIM:The purpose of our study was to build a multiple renal length nomogram for Hong Kong Asian children based on normal renal ultrasonography. METHODS:All children below the age of 13 years, who underwent ultrasonography in a local Hospital in Hong Kong from 23 September 2008 to 31 January 2009 due to melamine exposur...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2010.01714.x
更新日期：2010-06-01 00:00:00
abstract：AIM:To investigate the impact of regular exposure to paediatric medical trauma on multidisciplinary teams in a paediatric hospital and the relationships between psychological distress, resilience and coping skills. METHOD:Symptoms of post-traumatic stress disorder, secondary traumatic stress, depression, anxiety, stre...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12260
更新日期：2013-09-01 00:00:00
abstract：AIM:Early-revisits are frequent in the paediatric emergency department (ED) setting, but few data are available about early-revisited patients. The aim of this study was to investigate the hospitalisation rate of a population of early-revisited patients and to detect if an early-revisited patient was at risk of a more ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.13561
更新日期：2017-09-01 00:00:00
abstract：:We present a case of a 2-month-old boy with partially treated meningitis and suspected Pneumocystis carinii pneumonia. A full blood count revealed profound lymphopenia. The child was diagnosed with adenosine deaminase deficiency, a rare cause of severe combined immunodeficiency (SCID). SCID is an immunological emergen...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2010.01870.x
更新日期：2011-08-01 00:00:00
abstract：AIM:To compare weight gain and head growth in very-low-birthweight (VLBW, <1501 g) infants with or without exposure to short duration of skin-to-skin contact (STSC) during their stay in a neonatal intensive care unit. METHODS:Stable VLBW infants were randomised into either STSC or control group. Parents of the STSC gr...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1440-1754.2007.01198.x
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To explore the use of sun protection behaviours and the experience of sunburn in a sample of parents and their children in New Zealand. METHODOLOGY:Information was collected from 887 parents using postal questionnaires at the beginning of and during the summer. RESULTS:Thirty per cent of the parents believe...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.1998.00307.x
更新日期：1998-12-01 00:00:00
abstract：:Routine childhood immunizations are compulsory in a small number of countries, including the United States of America. Arguments used to justify making immunizations compulsory include enhancing the health of the community and treating as paramount the rights of the child to be protected against vaccine-preventable di...
journal_title：Journal of paediatrics and child health
pub_type： 历史文章,杂志文章
doi：10.1111/j.1440-1754.2004.00399.x
更新日期：2004-07-01 00:00:00
abstract：:This paper considers diagnostic frameworks in developmental-behavioural paediatrics. The purpose of a diagnostic assessment is reviewed, and the use of categorical diagnoses is explored. A multi-level process of diagnostic formulation is outlined, highlighting the importance of a comprehensive focus on presenting symp...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2011.02071.x
更新日期：2012-02-01 00:00:00
abstract：AIM:The aim of this study was to undertake a retrospective review of admissions and discharges to the neonatal unit at the National Hospital Guido Valadares, Dili, in order to gain insight into the epidemiology of hospitalised neonates in East Timor, as the information cannot be obtained from the hospital health manage...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12209
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To investigate the process and quality of informed consent, motivation and influence in parents who were invited to enroll their baby in a research project. METHODOLOGY:A mixed quantitative/qualitative questionnaire was sent to a cohort invited to participate in a physiological research project on sudden inf...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2001.00612.x
更新日期：2001-02-01 00:00:00
