Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence.

Abstract:

BACKGROUND:Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance. METHODS:This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery. RESULTS:Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores. CONCLUSIONS:These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Roten A,Baker NL,Gray KM

doi

10.1016/j.addbeh.2015.01.013

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

119-23

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(15)00014-3

journal_volume

45

pub_type

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