Gender-based impact of epidermal growth factor receptor mutation in patients with nonsmall cell lung cancer and previous tuberculosis.

Abstract:

:The association between tuberculosis (TB) and lung cancer is well known. However, carcinogenesis of TB and its connection with epidermal growth factor receptor (EGFR) mutation remains unclear. This study aimed to determine this connection to see if TB can affect the outcome of patients with lung cancer. This is a retrospective cohort study of patients with lung cancer receiving EGFR-tyrosine kinase inhibitors (TKIs) between 1996 and 2010 using the National Health Insurance Research Database of Taiwan. Because therapeutic response was required to apply EGFR-TKIs for >90 days, only patients with a follow-up of >120 days were studied and a responder was defined as intake of EGFR-TKIs >90 days. Predictors of EGFR-TKI response and survival were identified using logistic and Cox regression analyses, respectively. There were 8265 patients analyzed, including 6073 (73.5%) EGFR-TKI responder and 2192 (26.5%) nonresponder. A history of TB was found in 1.2% and 1.8% of the 2 groups, respectively. Comparing to male with pulmonary TB history, female with or without pulmonary TB history and male without pulmonary TB history all had a better EGFR-TKI response and 1-year progression-free survival (PFS). Gender and TB history were not independent prognostic factors of 2-year overall survival. The findings were similar in the subpopulation without chronic obstructive pulmonary disease, malignancies other than lung cancer, and low-income status. TB has a gender-dependent impact, with better EGFR-TKI response and 1-year PFS in female patients with lung cancer. The carcinogenesis and inflammation of TB may be different between genders.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Chang CH,Lee CH,Ho CC,Wang JY,Yu CJ

doi

10.1097/MD.0000000000000444

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

e444

issue

4

eissn

0025-7974

issn

1536-5964

pii

00005792-201501040-00019

journal_volume

94

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Liver stiffness measurement and spleen diameter as predictors for the presence of esophageal varices in chronic hepatitis C patients.

    abstract::Although it is an invasive and unpleasant procedure, esophagogastroduodenoscopy (EGD) is still the gold standard for esophageal varices (EV) detection. The aim of this study was to investigate liver stiffness measurement (LSM) and spleen diameter as simple noninvasive tools for EV prediction in chronic hepatitis C pat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008621

    authors: Tag-Adeen M,Alsenbesy M,Ghweil AA,Abd Elrazek MAH,Elgohary EA,Sallam MM,Ismael A,Nawara A

    更新日期:2017-11-01 00:00:00

  • Retrospective analysis of cervical cancer and precancerous lesions in patients with atypical squamous cells of undetermined significance in China.

    abstract::Atypical squamous cells of undetermined significance (ASCUS) are the most common cytological abnormality of all smear test. No study has demonstrated the prevalence of cervical cancer or its precursor in Chinese patients with ASCUS. This study aims to investigate the prevalence of cervical intraepithelial neoplasia 1 ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018239

    authors: Wang YY,Kong LH,Liu Y,Wang S,Fan QB,Zhu L,Lang JH

    更新日期:2019-12-01 00:00:00

  • Early oral feeding versus traditional feeding after transanal endorectal pull-through procedure in Hirschsprung's disease.

    abstract::Our study questioned whether the outcome of postoperative early oral feeding is different from traditional postoperative feeding in children with Hirschsprung's disease who underwent transanal endorectal pull-through.This was an observational and comparative study. Patients were allocated into 2 groups. Age, gender, f...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014829

    authors: Ashjaei B,Ghamari Khameneh A,Darban Hosseini Amirkhiz G,Nazeri N

    更新日期:2019-03-01 00:00:00

  • Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study.

    abstract::This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002734

    authors: Li X,Pang X,Zhang Q,Qu Q,Hou Z,Liu Z,Lv L,Na G,Zhang W,Sun C,Li Y

    更新日期:2016-02-01 00:00:00

  • Effectiveness of extracorporeal shock-wave therapy for frozen shoulder: A protocol for a systematic review of randomized controlled trial.

    abstract:BACKGROUND:This systematic review aims to explore the effectiveness and safety of extracorporeal shock-wave therapy (ESWT) for patients with frozen shoulder. METHODS:The sources of Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science,...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000014506

    authors: Cao DZ,Wang CL,Qing Z,Liu LD

    更新日期:2019-02-01 00:00:00

  • Early Markers of Tubulointerstitial Fibrosis in Children With Idiopathic Nephrotic Syndrome: Preliminary Report.

    abstract:UNLABELLED:Tubulointerstitial fibrosis and tubular atrophy play a crucial role in the pathogenesis of chronic kidney disease (CKD). They are also major determinants in chronic kidney disease development and progression in patients with primary renal diseases characterized by persistent or recurrent proteinuria. The pur...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001746

    authors: Bieniaś B,Zajączkowska M,Borzęcka H,Sikora P,Wieczorkiewicz-Płaza A,Wilczyńska B

    更新日期:2015-10-01 00:00:00

  • Cetuximab concurrent with IMRT versus cisplatin concurrent with IMRT in locally advanced nasopharyngeal carcinoma: A retrospective matched case-control study.

    abstract::To evaluate the treatment efficacies and toxicities of concurrent cetuximab-based bioradiotherapy (BRT) or cisplatin-based chemoradiotherapy (CRT) in locally advanced nasopharyngeal carcinoma. :Patients with previously untreated locally advanced nasopharyngeal carcinoma were matched into pairs, and enrolled into the s...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004926

    authors: Wu X,Huang J,Liu L,Li H,Li P,Zhang J,Xie L

    更新日期:2016-09-01 00:00:00

  • One case report of giant atypical leiomyoma of the ovary.

    abstract:RATIONALE:Ovarian leiomyoma is a rare ovarian tumor that occurs in 20-65 year-old women, and is mostly misdiagnosed as malignant tumor. In most reports on this type of tumor, ovarian myoma has a benign histology. Herein,we describe a case of ovarian atypical leiomyoma. PATIENT CONCERNS:The patient is a 58-year-old wom...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012526

    authors: Wang QM,Zhao Y,Ma Y,Yao LT,Han X

    更新日期:2018-10-01 00:00:00

  • Triglyceride glucose-body mass index is effective in identifying nonalcoholic fatty liver disease in nonobese subjects.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is highly correlated with obesity; however, it is not uncommon among nonobese individuals. Triglyceride (TG) and glucose index combined with body mass index (TyG-BMI) has been proposed as a favorable marker of insulin resistance. We soug...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007041

    authors: Zhang S,Du T,Li M,Jia J,Lu H,Lin X,Yu X

    更新日期:2017-06-01 00:00:00

  • A case report of primary central nervous system lymphoma with intestinal obstruction as the initial symptom.

    abstract:RATIONALE:Primary central nervous system lymphoma (PCNSL) with initial manifestations of constipation and intestinal obstruction (IO) is rare. PATIENT CONCERNS:A 50-year-old Chinese male patient was admitted to the gastroenterology department due to constipation and abdominal distention for 8 days. He had experienced ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010080

    authors: Li X,Qi S,Jiao Y,Gao J,Du H

    更新日期:2018-03-01 00:00:00

  • Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature.

    abstract:RATIONALE:Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagno...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000015053

    authors: Yang K,Jiang H,Li Q

    更新日期:2019-04-01 00:00:00

  • Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study.

    abstract::To investigate the effect of different dialysis modalities on the incidence of peripheral artery occlusive disease (PAOD) among patients with end-stage renal disease (ESRD) in a large population-based cohort study. The cohort study included 26,927 ESRD patients who underwent hemodialysis (17,737 patients, hemodialysis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001164

    authors: Lin CS,Chen SJ,Sung CC,Lin CL,Lin SH,Cheng SM,Wang IK,Huang WS,Kao CH

    更新日期:2015-07-01 00:00:00

  • Erratum: Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000003413.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000484496.43819.1a

    authors:

    更新日期:2016-08-19 00:00:00

  • Relationship between CT activity score with lung function and the serum angiotensin converting enzyme in pulmonary sarcoidosis on chest HRCT.

    abstract::To address the reliability of CT activity score (CTAS) and investigate the relationships between CTAS, lung function changes after treatment and the serum angiotensin-converting enzyme (SACE) levels.Fifty-seven sarcoidosis patients underwent chest high-resolution CT (HRCT) and spirometry, as well as SACE examination, ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012205

    authors: Duan J,Xu Y,Zhu H,Zhang H,Sun S,Sun H,Wang W,Xie S

    更新日期:2018-09-01 00:00:00

  • Does well-functioning hand constraint induce stress in forced-use therapy for children with unilateral cerebral palsy?

    abstract::This study investigated the stress induced by well-functioning hand constraint in forced-use therapy (FUT) for children with unilateral spastic cerebral palsy (CP).Seventeen children with unilateral spastic CP (mean age 5.8 years) received FUT: 4-week unaffected upper limb immobilization with a short-arm Scotchcast an...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019016

    authors: Ko EJ,Sung IY,Yuk JS

    更新日期:2020-03-01 00:00:00

  • Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention.

    abstract::Although the new oral P2Y12 inhibitors, prasugrel/ticagrelor have shown greater efficacy than clopidogrel in patients with the acute coronary syndrome, but they have not shown better efficacy in Korean patients. So we evaluated the efficacy of the prasugrel/ticagrelor in patients with myocardial infarction (MI) and di...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000014833

    authors: Ahn KT,Seong SW,Choi UL,Jin SA,Kim JH,Lee JH,Choi SW,Jeong MH,Chae SC,Kim YJ,Kim CJ,Kim HS,Cho MC,Gwon HC,Jeong JO,Seong IW,Korea Acute Myocardial Infarction Registry - National Institute of Health (KAMIR-NIH) Investigato

    更新日期:2019-03-01 00:00:00

  • Survival time and prognostic factors of patients with initial noncurative colorectal liver metastases.

    abstract::The true survival benefit of different curative strategies involving type of operative procedure and timing for patients with initial noncurative colorectal liver metastases remains uncertain. The goal of this study was to examine the effect of primary tumor resection on patients' survival and to clarify the predictiv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008831

    authors: Liu Q,Hao L,Lou Z,Gao X,Gong H,Hong Y,Fu C,Zhang W

    更新日期:2017-12-01 00:00:00

  • Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: A case report.

    abstract:INTRODUCTION:Systemic Bartonella spp. infections are being increasingly reported in association with complex medical presentations. Individuals with frequent arthropod exposures or animal contact appear to be at risk for acquiring long standing infections with Bartonella spp. CASE REPORT:This case report describes inf...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010465

    authors: Mozayeni BR,Maggi RG,Bradley JM,Breitschwerdt EB

    更新日期:2018-04-01 00:00:00

  • A prospective, randomized and controlled study of interscalene brachial plexus block for arthroscopic shoulder surgery: A comparison of C5 and conventional approach, a CONSORT-compliant article.

    abstract:BACKGROUND:The shoulder area is mainly innervated with the C5 and C6 nerve roots, and interscalene brachial plexus block (ISB) is widely used for postoperative analgesia after shoulder surgery. However, it is associated with adverse effects, such as numbness and weakness in the blocked arm due to an unwanted block of t...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000004921

    authors: Shin HJ,Na HS,Oh AY,Hwang JW,Kim BG,Park HP,Jeon YT,Min SW,Ryu JH

    更新日期:2016-09-01 00:00:00

  • Primary malignancy in giant cell tumor of thoracic vertebrae: A case report.

    abstract:RATIONALE:Primary malignancy in giant cell tumor of bone (PMGCTB) is extremely unusual. PMGCTB in the thoracic vertebrae is particularly rare. PATIENTS CONCERNS:A 23-year-old man was admitted with a chief complaint of chest pain associated with cough for approximately 3 days. Physical examination revealed a palpable, ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011484

    authors: Yu H,Shi R,Peng ZG,Yu BH,Cui JL

    更新日期:2018-07-01 00:00:00

  • Intraoperative blood salvage may shorten the lifespan of red blood cells within 3 days postoperatively: A pilot study.

    abstract:BACKGROUND:Intraoperative blood salvage (IBS) recovers most lost blood, and is widely used in the clinic. It is unclear why IBS does not reduce long-term postoperative requirements for red blood cells (RBCs), and 1 possibility is that IBS affects RBC lifespan. METHODS:Prospectively enrolled patients who underwent spin...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008143

    authors: Liao XY,Zuo SS,Meng WT,Zhang J,Huang Q,Gou DM

    更新日期:2017-09-01 00:00:00

  • Percutaneous transforaminal endoscopic decompression for the treatment of intraspinal tophaceous gout: A case report.

    abstract:RATIONALE:Intraspinal tophaceous gout is relatively rare condition presenting with major clinical manifestations, such as spinal cord or nerve roots compressions (radiculopathy). It is usually difficult to differentiate intraspinal tophaceous gout, lumbar disc herniation, stenosis of spinal canal, ossification of ligam...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020125

    authors: Chen X,Xu G,Hu Q,Zhao T,Bi Q,Huang Y,Shao H,Zhang J

    更新日期:2020-05-22 00:00:00

  • Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study.

    abstract::Gastric polyps are frequently reported in patients undergoing upper endoscopic procedures. In this retrospective study, the association between hyperplastic polyps and celiac disease in Northern Sardinia was estimated.Age, gender, body mass index, and medications taken in the 2 preceding months, including proton-pump ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005923

    authors: Dore MP,Pes GM,Rocchi C,Loria MF,Soro S,Bassotti G

    更新日期:2017-02-01 00:00:00

  • A 14-year literature survey on spine-related clinical research output by orthopedic surgeons from mainland China.

    abstract:BACKGROUND:In recent years, China is increasingly playing an active role in various fields of biomedical research. Many bibliometric studies have provided valuable insights to different fields of clinical studies. However, similar evaluation on spine surgery-related clinical research is still limited. We herein aimed t...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011959

    authors: Si G,Liu X,Xu N,Yu M,Liu X

    更新日期:2018-08-01 00:00:00

  • Pseudouveitis: a clue to the diagnosis of primary central nervous system lymphoma in immunocompetent patients.

    abstract::Primary oculocerebral non-Hodgkin lymphoma (NHL) of the immunocompetent patient is associated with significant morbidity and mortality, but early diagnosis and follow-up may improve prognosis. The eye, anatomically and embryologically part of the central nervous system (CNS), can be the primary site of the lymphomatou...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/01.md.0000134850.35118.46

    authors: Park S,Abad S,Tulliez M,Monnet D,Merlat A,Gyan E,Bouscary D,Dreyfus F,Grimaldi D,Dhote R,Rollot F,Kelaïdi C,Nazal EM,Brézin AP,Blanche P

    更新日期:2004-07-01 00:00:00

  • A case report of unexpected sudden cardiac death due to aortic rupture following laparoscopic appendectomy.

    abstract:INTRODUCTION:Aortic dissection is a very rare but life-threatening condition associated with a high mortality. Unexpected sudden cardiac death due to aortic rupture following laparoscopic appendectomy is very rare and may be difficult to diagnose. However, early diagnosis of aortic dissection is essential for the timel...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012823

    authors: Joo C,Min JW,Noh G,Seo J

    更新日期:2018-10-01 00:00:00

  • Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report.

    abstract:RATIONALE:The diagnosis of anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (IMT) remains challenging because of their morphological resemblance with spindle cell sarcoma with myofibroblastic characteristics. PATIENT CONCERNS:A 69-year-old female patient presented with loco-regional recurr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019577

    authors: Hou TC,Wu PS,Huang WY,Yang YT,Tan KT,Liu SH,Chen YJ,Chen SJ,Su YW

    更新日期:2020-03-01 00:00:00

  • Concurrent lymphoma and hemophilia B in a pediatric patient: A case report.

    abstract:INTRODUCTION:Lymphoma is the third most common cancer among children in the United States and Europe. Hemophilia is a congenital bleeding disorder characterized by deficiency of coagulation factor VIII or IX. Hemophilia B is a consequence of factor IX deficiency and has an incidence of 1 in 20,000 male births. A concur...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015474

    authors: Lu G,Qiao L,Li D,Liu Z,Zhao F,Yu D

    更新日期:2019-05-01 00:00:00

  • Efficacy and safety of Xiaofeng powder (xiao feng san) in treating urticaria: A protocol for a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Urticaria is a common skin disease that has a high impact on a patient's daily life. Xiaofeng powder (XFP) is one of the most commonly used Chinese herbal formula in China for urticaria. However, due to the lack of systematic evaluations, its clinical efficacy remains controversial. This meta-analysis was pe...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000013039

    authors: Chen G,Zhao J,Chen T,Zhang Z,Huang C,Xu Z,Xu H

    更新日期:2018-11-01 00:00:00

  • Chronic chorioretinal detachment under normal intraocular pressure in eye with uveitic glaucoma after trabeculectomy: A case report.

    abstract:RATIONALE:Choroidal detachment is a major postoperative complication of trabeculectomy. Postoperative choroidal detachment occurs with low intraocular pressure (IOP), and is naturally resolved by elevation of IOP. We report a case of chronic chorioretinal detachment (CRD) in the eye with uveitic glaucoma after trabecul...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018652

    authors: Sakurai Y,Takayama K,Abe T,Takeuchi M

    更新日期:2020-01-01 00:00:00