Abstract：
:CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, increase MDM2 and decrease levels of p53 and the p53 target p21/CDKN1A. CD24 silencing prevents functional inactivation of p53 by both somatic mutation and viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen. In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 mutates at a higher rate among glioma and prostate cancer samples with higher CD24 mRNA levels. These data provide a general mechanism for functional inactivation of ARF and reveal an important cellular context for genetic and viral inactivation of TP53.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Ydoi
10.1038/ncomms6909subject
Has Abstractpub_date
2015-01-20 00:00:00pages
5909issn
2041-1723pii
ncomms6909journal_volume
6pub_type
杂志文章abstract：:Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to targets that are in p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14465-z
更新日期：2020-01-31 00:00:00
abstract：:Naturally occurring single crystals having a multidomain morphology are a counterintuitive phenonomon: the macroscopic appearance is expected to follow the symmetry of the unit cell. Growing such crystals in the lab is a great challenge, especially from organic molecules. We achieve here uniform metallo-organic crysta...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13925-5
更新日期：2020-01-20 00:00:00
abstract：:Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15585-2
更新日期：2020-04-14 00:00:00
abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08276-6
更新日期：2019-01-18 00:00:00
abstract：:Van der Waals materials and their heterostructures offer a versatile platform for studying a variety of quantum transport phenomena due to their unique crystalline properties and the exceptional ability in tuning their electronic spectrum. However, most experiments are limited to devices that have lateral dimensions o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11379-3
更新日期：2019-07-26 00:00:00
abstract：:Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...
journal_title：Nature communications
pub_type： 杂志文章
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05821-1
更新日期：2018-09-04 00:00:00
abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09281-z
更新日期：2019-04-03 00:00:00
abstract：:Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characte...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2330
更新日期：2012-01-01 00:00:00
abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6969
更新日期：2015-01-19 00:00:00
abstract：:The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20071-w
更新日期：2020-12-04 00:00:00
abstract：:The extraction and combustion of fossil natural gas, consisting primarily of methane, generates vast amounts of greenhouse gases that contribute to climate change. However, as a result of recent research efforts, "solar methane" can now be produced through the photocatalytic conversion of carbon dioxide and water to m...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-019-10996-2
更新日期：2019-07-18 00:00:00
abstract：:Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initiall...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12980-2
更新日期：2019-11-01 00:00:00
abstract：:The deployment of next-generation renewable biofuels can be enhanced by improving their compatibility with the current infrastructure for transportation, storage and utilization. Propane, the bulk component of liquid petroleum gas, is an appealing target as it already has a global market. In addition, it is a gas unde...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5731
更新日期：2014-09-02 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-020-16538-5
更新日期：2020-06-03 00:00:00
abstract：:Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific expression analysi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17526-5
更新日期：2020-07-30 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms14013. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms15795
更新日期：2017-08-14 00:00:00
abstract：:Superionic ice is a special group of ice phases at high temperature and pressure, which may exist in ice-rich planets and exoplanets. In superionic ice liquid hydrogen coexists with a crystalline oxygen sublattice. At high pressures, the properties of superionic ice are largely unknown. Here we report evidence that fr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9156
更新日期：2015-08-28 00:00:00
abstract：:Cotton is an important natural fiber crop, however, its comprehensive and high-resolution gene map is lacking. Here we integrate four complementary high-throughput techniques, including Pacbio long read Iso-seq, strand-specific RNA-seq, CAGE-seq, and PolyA-seq, to systematically explore the transcription landscape acr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12575-x
更新日期：2019-10-17 00:00:00
abstract：:Rabies is a viral zoonosis transmitted by vampire bats across Latin America. Substantial public health and agricultural burdens remain, despite decades of bats culls and livestock vaccinations. Virally vectored vaccines that spread autonomously through bat populations are a theoretically appealing solution to managing...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19832-4
更新日期：2020-11-23 00:00:00
abstract：:Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5822
更新日期：2014-09-10 00:00:00
abstract：:Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by the chemical complexity of dissolved organic matter (DOM). Here, using bioassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simpl...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7711
更新日期：2015-03-31 00:00:00
abstract：:HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with decreased bone mineral density (BMD) in untreated HIV infection. Paradoxically, antiretroviral therapy (ART) wors...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9282
更新日期：2015-09-22 00:00:00
abstract：:Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11243-4
更新日期：2019-07-19 00:00:00
abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12248-9
更新日期：2019-09-16 00:00:00
abstract：:Multidrug resistance (MDR) represents a global threat to health. Here, we used whole genome sequencing to characterise Pseudomonas aeruginosa MDR clinical isolates from a hospital in Thailand. Using long-read sequence data we obtained complete sequences of two closely related megaplasmids (>420 kb) carrying large arra...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15081-7
更新日期：2020-03-13 00:00:00
abstract：:The continuum hypothesis states that both deterministic and stochastic processes contribute to the assembly of ecological communities. However, the contextual dependency of these processes remains an open question that imposes strong limitations on predictions of community responses to environmental change. Here we me...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9444
更新日期：2015-10-05 00:00:00
abstract：:Perceptual decisions are accompanied by feelings of confidence that reflect the likelihood that the decision was correct. Here we aim to clarify the relationship between perception and confidence by studying the same perceptual task across three different confidence contexts. Human observers were asked to categorize t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15561-w
更新日期：2020-04-09 00:00:00
abstract：:Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03683-1
更新日期：2018-04-03 00:00:00
abstract：:The temperature-jump technique, in which the sample is rapidly heated by a powerful laser pulse, has been widely used to probe the fast dynamics of folding of proteins and nucleic acids. However, the existing temperature-jump setups tend to involve sophisticated and expensive instrumentation, while providing only mode...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6737
更新日期：2014-12-17 00:00:00
