Abstract:
BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors and usually presented with locally advanced and distant metastasis disease, which prevent curative resection or treatments. In this regard, we considered identifying molecular subtypes associated with clinicopathological factor as prognosis factors to stratify PDAC for appropriate treatment of patients. RESULTS:In this study, we identified three molecular subtypes which were significant on survival time and metastasis. We also identified significant genes and enriched pathways represented for each molecular subtype. Considering R0 resection patients included in each subtype, metastasis and survival times are significantly associated with subtype 1 and subtype 2. CONCLUSIONS:We observed three PDAC molecular subtypes and demonstrated that those subtypes were significantly related with metastasis and survival time. The study may have utility in stratifying patients for cancer treatment.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Kim S,Kang M,Lee S,Bae S,Han S,Jang JY,Park Tdoi
10.1186/1475-925X-13-S2-S5subject
Has Abstractpub_date
2014-01-01 00:00:00pages
S5issn
1475-925Xpii
1475-925X-13-S2-S5journal_volume
13 Suppl 2pub_type
杂志文章abstract:BACKGROUND:Computer-assisted arrhythmia recognition is critical for the management of cardiac disorders. Various techniques have been utilized to classify arrhythmias. Generally, these techniques classify two or three arrhythmias or have significantly large processing times. A simpler autoregressive modeling (AR) techn...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925x-1-5
更新日期:2002-11-13 00:00:00
abstract:BACKGROUND:Dendritic cells are potent and specialized antigen presenting cells, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The dendritic cell-based vaccination against cancer has been clinically achieved promising successes. But there are still many challenges ...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-13-2
更新日期:2014-01-10 00:00:00
abstract:BACKGROUND:In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric oxide synthase (eNOS) encoding plasmid DNA administered using coated stents in a rabbit iliac artery restenosis model. METHODS:Lipopolyplexes (LPPs) with eNOS expressing plasmid DNA we...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-9-56
更新日期:2010-09-27 00:00:00
abstract:BACKGROUND:Surface roughness is the main factor determining bacterial adhesion, biofilm growth and plaque formation on the dental surfaces in vivo. Air-polishing of dental surfaces removes biofilm but can also damage the surface by increasing its roughness. The purpose of this study was to investigate the surface damag...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-9-59
更新日期:2010-10-12 00:00:00
abstract:BACKGROUND:We and others have previously demonstrated that adipose-derived stem cells (ASCs) transplantation improve cardiac dysfunction post-myocardium infarction (MI) under hemodynamic stress in rats. The beneficial effects appear to be associated with pleiotropic factors due to a complex interplay between the transp...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-13-54
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The loss of the notochordal cells from the nucleus pulposus is associated with ageing and disc degeneration. However, understanding the mechanisms responsible for the loss of these cells has been hampered in part due to the difficulty of culturing and maintaining their phenotype. Furthermore, little is known...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-6-33
更新日期:2007-09-06 00:00:00
abstract:PURPOSE:Coronary artery bypass graft (CABG) surgery represents the standard treatment of advanced coronary artery disease. Two major types of anastomosis exist to connect the graft to the coronary artery, i.e., by using an end-to-side or a side-to-side anastomosis. There is still controversy because of the differences ...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-6-35
更新日期:2007-09-26 00:00:00
abstract:BACKGROUND:Cerebral hyperperfusion syndrome develops in a small subset of patients following carotid artery surgery (CAS) performed to treat severe carotid artery stenosis. This syndrome has been found to have a close correlation with cerebral hyperperfusion occurring after CAS. The purpose of this study is to investig...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-10-84
更新日期:2011-09-23 00:00:00
abstract:BACKGROUND:Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall circumferential strain and its instantaneous wall shear stress is known as stress phase angle (SPA...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0458-8
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:State-of-the-art signal processing methods are known to detect information in single-trial event-related EEG data, a crucial aspect in development of real-time applications such as brain computer interfaces. This paper investigates one such novel approach, evaluating how individual classifier and feature sub...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-6-32
更新日期:2007-08-23 00:00:00
abstract:BACKGROUND:This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical diagnosis and management. This methodology employs a simple waveform contour analysis approach to comp...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0603-4
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Endovascular intervention using a stent is a mainstream treatment for cerebral aneurysms. To assess the effect of intervention strategies on aneurysm hemodynamics, we have developed a fast virtual stenting (FVS) technique to simulate stent deployment in patient-specific aneurysms. However, quantitative valid...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0250-6
更新日期:2016-12-28 00:00:00
abstract:BACKGROUND:Recent studies indicate that the blue-yellow colour discrimination is impaired in ADHD individuals. However, the relationship between colour and performance has not been investigated. This paper describes the development and the testing of a virtual environment that is capable to quantify the influence of re...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-10-74
更新日期:2011-08-19 00:00:00
abstract:PURPOSE:We propose a collaborative and secure transmission scheme in order to safely and efficiently transmit medical data and provide telemedicine services, lighten the load on wireless access networks, and improve the quality of medical treatment such as surgery. METHODS:First, the transmission technology based on o...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-019-0674-x
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Speech production and speech phonetic features gradually improve in children by obtaining audio feedback after cochlear implantation or using hearing aids. The aim of this study was to develop and evaluate automated classification of voice disorder in children with cochlear implantation and hearing aids. ME...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-10-3
更新日期:2011-01-14 00:00:00
abstract:BACKGROUND:Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that significant growth can be ob...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-8-11
更新日期:2009-06-18 00:00:00
abstract:BACKGROUND:Tumor hypoxia is involved in every stage of solid tumor development: formation, progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors-chronic hypoxia and acute hypoxia. Recent studies indicate that the regional hypoxia kinetics is closely linked to metastasis and therapeutic responses,...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0235-5
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:To determine how the mechanical property and micro structure affect tissue regeneration and angiogenesis, three types of scaffolds were studied. Acellular dermal matrices (ADM), produced from human skin by removing the epidermis and cells, has been widely used in wound healing because of its high mechanical ...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-12-125
更新日期:2013-12-04 00:00:00
abstract:BACKGROUND:Quantizing the Breast Imaging Reporting and Data System (BI-RADS) criteria into different categories with the single ultrasound modality has always been a challenge. To achieve this, we proposed a two-stage grading system to automatically evaluate breast tumors from ultrasound images into five categories bas...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-019-0626-5
更新日期:2019-01-24 00:00:00
abstract::The control of robotic prostheses based on pattern recognition algorithms is a widely studied subject that has shown promising results in acute experiments. The long-term implementation of this technology, however, has not yet been achieved due to practical issues that can be mainly attributed to the use of surface el...
journal_title:Biomedical engineering online
pub_type: 杂志文章,评审
doi:10.1186/1475-925X-11-33
更新日期:2012-06-20 00:00:00
abstract:BACKGROUND:Image quality assessment method of photoacoustic tomography has not been completely standardized yet. Due to the combined nature of photonic signal generation and ultrasonic signal transmission in biological tissue, neither optical nor ultrasonic traditional methods can be used without modification. An optic...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-11-37
更新日期:2012-07-13 00:00:00
abstract:BACKGROUND:It is a known fact that blood flow pattern and more specifically the pulsatile time variation of shear stress on the vascular wall play a key role in atherogenesis. The paper presents the conception, the building and the control of a new in vitro test bench that mimics the pulsatile flows behavior based on i...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-015-0065-x
更新日期:2015-08-07 00:00:00
abstract:BACKGROUND:In magnetic resonance electrical impedance tomography (MREIT), we reconstruct conductivity images using magnetic flux density data induced by externally injected currents. Since we extract magnetic flux density data from acquired MR phase images, the amount of measurement noise increases in regions of weak M...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-13-87
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:The QRS complex is the most noticeable feature in the electrocardiogram (ECG) signal, therefore, its detection is critical for ECG signal analysis. The existing detection methods largely depend on hand-crafted manual features and parameters, which may introduce significant computational complexity, especiall...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0441-4
更新日期:2018-01-29 00:00:00
abstract:BACKGROUND:Since hemodynamics plays a key role in the development and evolution of cardiovascular pathologies, physician's decision must be based on proper monitoring of relevant physiological flow quantities. METHODS:A numerical analysis of the error introduced by an intravascular Doppler guide wire on the peak veloc...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0234-6
更新日期:2016-10-10 00:00:00
abstract::It was highlighted that the original article [1] had an omission in the Abstract. This Correction article shows the omitted sentence: "This article [1] was awarded the SIAMOC Best Methodological Paper 2018". ...
journal_title:Biomedical engineering online
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12938-019-0698-2
更新日期:2019-07-23 00:00:00
abstract::Herman P. Schwan [1915-2005] was a distinguished scientist and engineer, and a founding father of the field of biomedical engineering. A man of integrity, Schwan influenced the lives of many, including his wife and children, and his many students and colleagues. Active in science until nearly the end of his life, he w...
journal_title:Biomedical engineering online
pub_type: 传,历史文章,杂志文章
doi:10.1186/1475-925X-4-21
更新日期:2005-03-25 00:00:00
abstract:BACKGROUND:Shape of the dental root canal is highly patient specific. Automated identification methods of the medial line of dental root canals and the reproduction of their 3D shape can be beneficial for planning endodontic interventions as severely curved root canals or multi-rooted teeth may pose treatment challenge...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-11-81
更新日期:2012-10-29 00:00:00
abstract:BACKGROUND:Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescent protein mKate2 for a long-term non-invasive tumor imaging in BALB/c nude mice, by using a low-powe...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0615-0
更新日期:2018-12-29 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (NO) is a selective pulmonary vasodilator used primarily in the critical care setting for patients concurrently supported by invasive or noninvasive positive pressure ventilation. NO delivery devices interface with ventilator breathing circuits to inject NO in proportion with the flow of...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0227-5
更新日期:2016-08-30 00:00:00