Differences in rates of radiation-induced true and false rib fractures after stereotactic body radiation therapy for Stage I primary lung cancer.

Abstract:

:The purpose of this study was to analyze the dosimetry and investigate the clinical outcomes of radiation-induced rib fractures (RIRFs) after stereotactic body radiotherapy (SBRT). A total of 126 patients with Stage I primary lung cancer treated with SBRT, who had undergone follow-up computed tomography (CT) at least 12 months after SBRT and who had no previous overlapping radiation exposure were included in the study. We used the Mantel-Haenszel method and multiple logistic regression analysis to compare risk factors. We analyzed D(0.5 cm(3)) (minimum absolute dose received by a 0.5-cm(3) volume) and identified each rib that received a biologically effective dose (BED) (BED3, using the linear-quadratic (LQ) formulation assuming an α/β = 3) of at least 50 Gy. Of the 126 patients, 46 (37%) suffered a total of 77 RIRFs. The median interval from SBRT to RIRF detection was 15 months (range, 3-56 months). The 3-year cumulative probabilities were 45% (95% CI, 34-56%) and 3% (95% CI, 0-6%), for Grades 1 and 2 RIRFs, respectively. Multivariate analysis showed that tumor location was a statistically significant risk factor for the development of Grade 1 RIRFs. Of the 77 RIRFs, 71 (92%) developed in the true ribs (ribs 1-7), and the remaining six developed in the false ribs (ribs 8-12). The BED3 associated with 10% and 50% probabilities of RIRF were 55 and 210 Gy to the true ribs and 240 and 260 Gy to the false ribs. We conclude that RIRFs develop more frequently in true ribs than in false ribs.

journal_name

J Radiat Res

authors

Miura H,Inoue T,Shiomi H,Oh RJ

doi

10.1093/jrr/rru107

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

332-7

issue

2

eissn

0449-3060

issn

1349-9157

pii

rru107

journal_volume

56

pub_type

杂志文章
  • Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map.

    abstract::In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw083

    authors: Kanzaki N,Kataoka T,Etani R,Sasaoka K,Kanagawa A,Yamaoka K

    更新日期:2017-01-01 00:00:00

  • Microbeam studies of the bystander response.

    abstract::Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coi...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.09012s

    authors: Prise KM,Schettino G,Vojnovic B,Belyakov O,Shao C

    更新日期:2009-03-01 00:00:00

  • Mutation induction and RBE of low energy neutrons in V79 cells.

    abstract::We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.s21

    authors: Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

    更新日期:1999-12-01 00:00:00

  • Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients.

    abstract::The current study retrospectively analyzed the results of radiotherapy for clinically localized sebaceous carcinoma of the eyelid.We reviewed records of 83 patients with histologically confirmed sebaceous carcinoma who were treated radiotherapeutically between 1983 and 2015. Sixty-five patients (78%) were initially tr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz046

    authors: Takagawa Y,Tamaki W,Suzuki S,Inaba K,Murakami N,Takahashi K,Igaki H,Nakayama Y,Shigematsu N,Itami J

    更新日期:2019-10-23 00:00:00

  • Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice.

    abstract::The radioprotective effect of chitosan was studied in mice following whole-body X-ray irradiation. C3H/He mice were exposed to 7 Gy, and their survival rates were examined. The survival rates of chitosan-diet mice were about 20% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau a...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.44.53

    authors: Nishimura Y,Kim HS,Ikota N,Arima H,Bom HS,Kim YH,Watanabe Y,Yukawa M,Ozawa T

    更新日期:2003-03-01 00:00:00

  • Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells.

    abstract::Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv039

    authors: Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

    更新日期:2015-09-01 00:00:00

  • Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons.

    abstract::The direct biological effects of radiation, particularly accelerated heavy particle ions, on neurons are not fully known. Hence, the direct effect of carbon-ion beams on immature neurons was investigated by comparing to the effect of X-rays in vitro using primary hippocampal neurons. Primary neurons were prepared from...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10050

    authors: Kaminuma T,Suzuki Y,Shirai K,Mizui T,Noda SE,Yoshida Y,Funayama T,Takahashi T,Kobayashi Y,Shirao T,Nakano T

    更新日期:2010-01-01 00:00:00

  • Analysis of cardiac toxicity after definitive chemoradiotherapy for esophageal cancer using a biological dose-volume histogram.

    abstract::This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and the dose-volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed the data of 83 patients with esophageal cancer treated using definitive...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa001

    authors: Takeuchi Y,Murakami Y,Kameoka T,Ochi M,Imano N,Takahashi I,Nishibuchi I,Kimura T,Kawahara D,Saito A,Nagata Y

    更新日期:2020-03-23 00:00:00

  • Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules?

    abstract::In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1093/jrr/rrw015

    authors: Shibamoto Y,Miyakawa A,Otsuka S,Iwata H

    更新日期:2016-08-01 00:00:00

  • Quantifying biological effects of radiation from high-energy linear accelerators on lymphocytes.

    abstract::The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz073

    authors: Farkas G,Kocsis ZS,Székely G,Mihály D,Pesznyák C,Pócza T,Major T,Polgár C,Jurányi Z

    更新日期:2020-01-23 00:00:00

  • A novel monofunctional DNA glycosylase activity against thymine glycol in mouse cell nuclei.

    abstract::Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.07100

    authors: Yamamoto R,Akiyama M,Ide H,Yamamoto K,Matsuyama S,Kubo K

    更新日期:2008-05-01 00:00:00

  • What motivated medical students and residents to become radiation oncologists in Japan?-Questionnaire report by the radiotherapy promotion committee of JASTRO.

    abstract::This study aimed to clarify the motivations and timing of the decision to become radiation oncologists. MATERIALS AND METHODS:We conducted an online survey for new members of the Japanese Society for Radiation Oncology (JASTRO). RESULTS:The response rate was 43.3%. Data of the 79 respondents who wanted to obtain a b...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa051

    authors: Murakami Y,Noda SE,Hatayama Y,Maebayashi T,Jingu K,Nagata Y,Mizowaki T

    更新日期:2020-09-08 00:00:00

  • Acquired radioresistance after low dose X-irradiation in mice.

    abstract::Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.31.256

    authors: Yonezawa M,Takeda A,Misonoh J

    更新日期:1990-09-01 00:00:00

  • Dosimetry of mixed neutron and gamma radiation with paired Fricke solutions in light and heavy water.

    abstract::Paired Fricke solutions, made up from light water or heavy water and 0.8N in H2SO4 and 1 mM in Fe(NH4)2(SO4)2 and NaCl, were calibrated with 60Co gamma rays and with mixed neutron and gamma radiation from a 252Cf source. Absorbance increases, AL and AH, in light- and heavy-water Fricke dosimeters, respectively, increa...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.37.97

    authors: Himit M,Itoh T,Endo S,Fujikawa K,Hoshi M

    更新日期:1996-06-01 00:00:00

  • Dosimetric comparison between volumetric modulated arc therapy planning techniques for prostate cancer in the presence of intrafractional organ deformation.

    abstract::The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverag...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa123

    authors: Varnava M,Sumida I,Oda M,Kurosu K,Isohashi F,Seo Y,Otani K,Ogawa K

    更新日期:2020-12-21 00:00:00

  • Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.

    abstract::When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s209

    authors: Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

    更新日期:2002-12-01 00:00:00

  • Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: a multi-institutional retrospective research study.

    abstract::The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer p...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jrr/rrv036

    authors: Ariga T,Toita T,Kato S,Kazumoto T,Kubozono M,Tokumaru S,Eto H,Nishimura T,Niibe Y,Nakata K,Kaneyasu Y,Nonoshita T,Uno T,Ohno T,Iwata H,Harima Y,Wada H,Yoshida K,Gomi H,Numasaki H,Teshima T,Yamada S,Nakano T

    更新日期:2015-09-01 00:00:00

  • Subjective voice quality, communicative ability and swallowing after definitive radio(chemo)therapy, laryngectomy plus radio(chemo)therapy, or organ conservation surgery plus radio(chemo)therapy for laryngeal and hypopharyngeal cancer.

    abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru093

    authors: Szuecs M,Kuhnt T,Punke C,Witt G,Klautke G,Kramp B,Hildebrandt G

    更新日期:2015-01-01 00:00:00

  • Time course of reoxygenation in experimental murine tumors after carbon-beam and X-ray irradiation.

    abstract::We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irrad...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.42.131

    authors: Oya N,Sasai K,Shibata T,Takagi T,Shibuya K,Koike S,Nojima K,Furusawa Y,Ando K,Hiraoka M

    更新日期:2001-06-01 00:00:00

  • Clinical factors related to recurrence after hepatic arterial concurrent chemoradiotherapy for advanced but liver-confined hepatocellular carcinoma.

    abstract::Before the sorafenib era, advanced but liver-confined hepatocellular carcinoma (HCC) was treated by liver-directed therapy. Hepatic arterial concurrent chemoradiotherapy (CCRT) has been performed in our group, giving substantial local control but frequent failure. The aim of this study was to analyze patterns of failu...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt034

    authors: Cha H,Yoon HI,Lee IJ,Koom WS,Han KH,Seong J

    更新日期:2013-11-01 00:00:00

  • The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy.

    abstract::New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesor...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz092

    authors: Alickikus ZA,Kuru A,Aydin B,Akcay D,Gorken IB

    更新日期:2020-03-23 00:00:00

  • Reassessment of gamma-ray doses in Hiroshima and Nagasaki.

    abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement_40

    authors: Maruyama T,Kumamoto Y,Noda Y

    更新日期:1991-03-01 00:00:00

  • Can the two mechanisms of tumor cell killing by radiation be exploited for therapeutic gain?

    abstract::The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1093/jrr/rrt111

    authors: Chapman JD

    更新日期:2014-01-01 00:00:00

  • Optimized enzymatic dual functions of PaPrx protein by proton irradiation.

    abstract::We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt081

    authors: Park CH,Lee SS,Kim KR,Jung MH,Lee SY,Cho EJ,Singh S,Chung BY

    更新日期:2014-01-01 00:00:00

  • Multimodal approaches including three-dimensional conformal re-irradiation for recurrent or persistent esophageal cancer: preliminary results.

    abstract::The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradi...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.11066

    authors: Yamaguchi S,Ohguri T,Imada H,Yahara K,Moon SD,Higure A,Yamaguchi K,Yoshikawa I,Harada M,Korogi Y

    更新日期:2011-01-01 00:00:00

  • Synthetic trehalose dicorynomycolate (S-TDCM): behavioral effects and radioprotection.

    abstract::This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.38.45

    authors: Landauer MR,McChesney DG,Ledney GD

    更新日期:1997-03-01 00:00:00

  • Growth retardation of Paramecium and mouse cells by shielding them from background radiation.

    abstract::In the 1970s and 1980s, Planel et al. reported that the growth of paramecia was decreased by shielding them from background radiation. In the 1990s, Takizawa et al. found that mouse cells displayed a decreased growth rate under shielded conditions. The purpose of the present study was to confirm that growth is impaire...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.11145

    authors: Kawanishi M,Okuyama K,Shiraishi K,Matsuda Y,Taniguchi R,Shiomi N,Yonezawa M,Yagi T

    更新日期:2012-01-01 00:00:00

  • Inter-fractional variations in the dosimetric parameters of accelerated partial breast irradiation using a strut-adjusted volume implant.

    abstract::The aim of the study was to evaluate inter-fractional dosimetric variations for high-dose rate breast brachytherapy using a strut-adjusted volume implant (SAVI). For the nine patients included, dosimetric constraints for treatment were as follows: for the planning target volume for evaluation (PTV_Eval), the volume re...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz061

    authors: Iijima K,Okamoto H,Takahashi K,Aikawa A,Wakita A,Nakamura S,Nishioka S,Harada K,Notake R,Sugawara A,Yoshimura R,Kunieda E,Itami J

    更新日期:2020-01-23 00:00:00

  • Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions.

    abstract::The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome co...

    journal_title:Journal of radiation research

    pub_type: 临床试验,杂志文章

    doi:10.1269/jrr.45.195

    authors: Lee R,Yamada S,Yamamoto N,Miyamoto T,Ando K,Durante M,Tsujii H

    更新日期:2004-06-01 00:00:00

  • Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction.

    abstract::In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on ce...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.46.401

    authors: Ogino H,Shibamoto Y,Sugie C,Ito M

    更新日期:2005-12-01 00:00:00