Abstract：
BACKGROUND:Obstructive sleep apnea (OSA) has been increasingly linked to elevated blood pressure (BP) and hypertension. Repeated night-time hypoxia in OSA is associated with activation of two critical mechanisms of BP control: the autonomic nervous system and the renin-angiotensin system (RAS). The effects of OSA on the RAS are not well understood, especially in children. We hypothesized that children with OSA have elevated renin levels and abnormal relationships between BP and renin. METHODS:Polysomnography was conducted in 173 children to diagnose OSA (apnea-hypopnea index [AHI] >1 event/h) and control (AHI ≤1 event/h) groups. Age- and gender-specific z-scores for body mass index (BMI) were calculated to divide subjects into obese (BMI ≥95%), overweight (BMI ≥85% and <95%) and normal-weight (BMI <85%) groups. Morning BP was measured with an automatic sphygmomanometer and venous blood samples were collected for measurements of plasma renin, after overnight polysomnography. RESULTS:Plasma renin levels were not significantly different in all four groups after adjustment of age, gender, and race. Significantly negative associations between renin and BP were present only in the normal-weight control group and were absent in the other three groups. CONCLUSION:Plasma renin levels were not significantly increased in children with OSA compared to controls for both normal-weight and overweight subjects. The absence of normal, negative renin-BP relationships in both overweight and OSA children suggests a dysfunction of the RAS, which could be a mechanism for increased BP and the development of hypertension.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Shamsuzzaman A,Szczesniak RD,Fenchel MC,Amin RSdoi
10.1016/j.sleep.2014.05.022subject
Has Abstractpub_date
2015-01-01 00:00:00pages
101-6issue
1eissn
1389-9457issn
1878-5506pii
S1389-9457(14)00256-1journal_volume
16pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract：STUDY OBJECTIVE:We analyzed archival data from an epidemiology study to test the association between vitamin use and sleep. DESIGN:Random digit dialing was used to recruit 772 people ranging in age from 20 to 98 for a study of people's sleep experience. These individuals completed a set of questionnaires about their s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.12.009
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To produce a valid insomnia treatment satisfaction questionnaire (ITSAT-Q) to assess treatment satisfaction with pharmacotherapy for use in patients with insomnia. PATIENTS AND METHODS:Items developed for a self-administered questionnaire were analyzed using exploratory factor analysis (EFA), which produced 5 ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2009.12.010
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVES:The microbiota-gut-brain axis is an intricate communication network that is emerging as a key modulator of psychological and physiological wellbeing. Recent pioneering work in the field has suggested a possible link between gut microbiome composition with sleep, an evolutionarily conserved behavior demonstra...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.04.013
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:The association between restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) has seldom been reported. There is one study reporting improvement of RLS symptoms severity in patients naive of treatment after initiation of continuous positive airway pressure (CPAP) for OSAS. The aim of this s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.06.023
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:Sleep-disordered breathing is associated with hypertension and cardiovascular disease. Increased aortic stiffness is one possible linking mechanism. We evaluated the association between sleep-disordered breathing and aortic stiffness in a community-based sample. METHODS:Our community-based cross-sectional ob...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.11.009
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:This study aimed to evaluate children's bedtime, wake-up time, total sleep duration (TSD), sleep latency, and daytime napping by age and gender. Its secondary aim was to compare sleep duration among demographic and lifestyle factors. METHODS:We performed a cross-sectional study of 3639 children in Daegu, Ko...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.03.011
更新日期：2010-06-01 00:00:00
abstract：STUDY OBJECTIVES:Using a multi-method design, this study examined the construct validity of the Parent-Child Sleep Interactions Scale (PSIS; Alfano et al., 2013), which measures sleep-related parenting behaviors and interactions that contribute to preschoolers' sleep problems. METHODS:Participants included a community...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.04.002
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:As the relationships of sleep-wake schedule and mealtime with children's behaviors have not often been studied together, we investigated the relationships of these lifestyles variables with preschool children's well-being. METHODS:Using a network survey, we investigated several lifestyle variables of 1000 fa...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.03.023
更新日期：2019-09-01 00:00:00
abstract：:This report describes a patient with iron deficiency in bone marrow examination and iron-responsive restless legs syndrome (RLS), in whom serum ferritin levels were well above the conventional cutoff for considering iron deficiency. The predictive value of serum ferritin for iron deficiency in RLS depends on the cutof...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2004.10.008
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To explore the correlates of nocturnal sleep duration, nocturnal sleep variability, and nocturnal sleep problems in a sample of Australian toddlers. METHODS:Participants were 173 toddlers (average age 19.7 ± 4.1 months) from the GET UP! STUDY:Nocturnal sleep duration, nocturnal sleep variability, nap(s) and...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2018.08.035
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:Women with premenstrual dysphoric disorder (PMDD) experience disturbed mood, altered melatonin circadian rhythms, and frequent reports of insomnia during the luteal phase (LP) of their menstrual cycle. In this study we aimed to investigate nocturnal polysomnographic (PSG) sleep across the menstrual cycle in ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2012.05.012
更新日期：2012-09-01 00:00:00
abstract：:Floppy eyelid syndrome (FES) is a recently recognized entity, originally described in obese men with easily everted upper eyelids and chronic ocular irritation. Although the eyelids are primarily involved, other ocular structures such as the conjunctiva and cornea are frequently affected and cause much of the morbidit...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2005.07.001
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:Two doses of EVT 201, a partial positive allosteric modulator of the GABA(A) system, were evaluated in elderly primary insomnia patients with daytime sleepiness. PATIENTS AND METHODS:Participants were 149 elderly patients with DSM-IV primary insomnia including evidence of daytime sleepiness (53 males, 96 fem...
journal_title：Sleep medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.sleep.2009.07.012
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To estimate the prevalence of insomnia symptoms and syndrome in the general population, describe the types of self-help treatments and consultations initiated for insomnia, and examine help-seeking determinants. PATIENTS AND METHODS:A randomly selected sample of 2001 French-speaking adults from ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2005.08.008
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:Erectile dysfunction (ED) is highly prevalent in obstructive sleep apnea (OSA), however, the effect of continuous positive airway pressure (CPAP) therapy on erectile function has not yet been thoroughly investigated in these patients. METHODS:Ninety-four men with severe OSA (ie, with an apnea-hypopnea-index...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2018.03.018
更新日期：2019-01-01 00:00:00
abstract：:Circadian clocks are intracellular molecular mechanisms designed to allow the cell, organ, and organism to prepare for an anticipated stimulus prior to its onset. In order for circadian clocks to maintain their selective advantage, they must be entrained to the environment. Light, sound, temperature, physical activity...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2006.12.010
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Sleep quality affects all aspects of daily functioning, and it is vital for facilitating recovery from illness and injury. Sleep commonly becomes disrupted following moderate to severe brain injury, yet little is known about the prevalence of sleep disruption over time and how it impacts on recovery followin...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.04.013
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:There have been few quality of life (QoL) studies of patients with restless legs syndrome (RLS) in Asian countries. We studied the QoL of patients with RLS and compared it to normal controls and patients with hypertension, type 2 diabetes, or osteoarthritis in Korea. METHODS:A total of 215 RLS patients (141...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2012.05.005
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To examine the associations between sleep hygiene and sleep patterns in children ages newborn to 10 years. The relationships between key features of good sleep hygiene in childhood and recognizable outcomes have not been studied in large, nationally representative samples. PARTICIPANTS AND METHODS:A national...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.07.016
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Relatively few epidemiologic studies have focused on narcolepsy, a disabling sleep disorder with a strong association with HLA-DQB1 *0602. METHODS:We sought to estimate the prevalence of narcolepsy using multiple overlapping techniques to identify residents of King County, WA who were 18 years or older with...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.05.009
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Prior studies report less favorable sleep characteristics among non-Whites as compared with non-Hispanic Whites. However, few population-based studies have used objective measures of sleep duration, especially in more than two racial/ethnic groups. We tested whether objectively estimated sleep duration and s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.07.005
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To provide normative values for sleep macroarchitecture of healthy children aged 1-18 years using the AASM sleep scoring criteria, assessing the effects of gender, age, and Tanner pubertal stage. METHODS:One-night polysomnography was performed at subjects' habitual bedtimes in 16 laboratories on 209 healthy ...
journal_title：Sleep medicine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.sleep.2010.11.011
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:The aim was to study, with a developmental approach, the longitudinal association between night-waking from age 2 to 5-6 years and behavior at age 5-6 years. METHODS:Within the French birth cohort study Etude sur les Déterminants pré et post natals du développement et de la santé de l'ENfant (EDEN), repeated...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.10.008
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE(S):(a) To determine if self-reported diabetes mellitus is independently associated with sleep-disordered breathing (SDB); (b) to determine if diabetes mellitus is specifically associated with central sleep apnea including periodic breathing (Cheyne-Stokes breathing pattern) during sleep. STUDY POPULATION:The...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(03)00118-7
更新日期：2003-07-01 00:00:00
abstract：:We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(99)00016-7
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:With the onset of the COVID-19 outbreak there has been concern that patients with obstructive sleep apnea (OSA) who develop COVID-19 may be at risk of greater morbidity and mortality than patients without OSA. COVID-19 is associated with an increased mortality in the elderly and particularly those with obesi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.07.013
更新日期：2020-10-01 00:00:00
abstract：:A 63-year-old right-handed woman developed an alien hand syndrome (AHS) after an acute infarction in the territory of the left anterior cerebral artery. The uncontrolled hand movements were present during the daytime and eventually disturbed sleep. Polysomnography revealed that these motor actions only appeared when t...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(02)00236-8
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:To date few studies have examined how multiple layers of influences shape the emergence of bed-sharing practices in the first 2 years postpartum. In our report, we examined bed-sharing in a large multiethnic sample, exploring the influences of three broad classes of influence on bed-sharing at single time po...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.04.019
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To explore the gender differences of brain regional homogeneity (ReHo) in healthy subjects during the resting-state, after normal sleep, and after sleep deprivation (SD) using functional magnetic resonance imaging (fMRI) and the ReHo method. METHODS:Sixteen healthy subjects (eight males and eight females) ea...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2011.09.019
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Sleep contributes to processes of memory, but many questions still remain open. The aim of this study was to test the role of different aspects of sleep for memory performance in a group of patients with chronic non-restorative sleep. METHODS:Forty-two consecutive patients (mean age 40.3 years; 31 women) wit...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.11.014
更新日期：2007-08-01 00:00:00
