Abstract：
:The objective of this study was to develop mucoadhesive polymeric excipients for vaginal drug delivery systems. Hyaluronic acid was thiolated and subsequently preactivated with 6-mercaptonicotinamide (HA-CYS-MNA) to enhance stability and mucoadhesive properties on vaginal mucosa. After determination of the thiol group content, disintegration studies and in vitro mucoadhesion studies (rotating cylinder and tensile) were performed. Furthermore, swelling behavior and cytotoxicity studies were performed in comparison with corresponding polymers. Both, disintegration and in vitro mucoadhesive studies revealed that modifying HA-CYS with MNA resulted in higher stability (3.6-fold prolonged disintegration time compared to unmodified hyaluronic acid) and prolonged mucoadhesion time. MTT assay and LDH revealed no toxicity for the polymeric excipients and safe for their use. Disintegration and swelling results conducted more pronounced stability of the preactivated thiomers compared to corresponding unmodified ones. According to these results preactivated hyaluronic acid might be a useful tool for vaginal delivery systems.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Nowak J,Laffleur F,Bernkop-Schnürch Adoi
10.1016/j.ijpharm.2014.11.048subject
Has Abstractpub_date
2015-01-15 00:00:00pages
383-389issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(14)00863-1journal_volume
478pub_type
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