One size does not fit all: the merit of absorbed doses to the blood in 131I therapy for differentiated thyroid carcinoma.

Abstract:

:The amount of 131I necessary for successful ablation in patients with differentiated thyroid cancer (DTC) is still subject to debate. This study investigates the relationship of the absorbed dose of radiation to the blood while administering 131I activity with several other parameters in DTC patients. This prospective study included 90 DTC patients who were classified into three groups according to their level of dosage: 3.7 GBq (38.9%), 5.55 GBq (55.6%), and 7.4 GBq (5.5%). Blood dosimetry of treated patients was performed using external whole-body counting with a Geiger Muller dosimeter located 2 m away from the patients. Dose rate was measured at 2, 4, 5, 24, and 48 h after the administration of radioiodine. Based on the results of whole-body dose rate measurements, 48 h after administration of 3.7, 5.55, and 7.4 GBq of radioiodine, absorbed doses to patients' blood were estimated at 0.49 ± 0.12, 0.71 ± 0.21, and 0.76 ± 0.11 Gy, respectively. Increasing radioiodine dosage from 3.7 GBq to 5.55 GBq significantly increased blood dose, while there was no significant difference in blood dose between radioiodine dosages of 5.55 GBq and 7.4 GBq. The absorbed dose to the blood was significantly correlated to the patients' gender and the presence of lymph node metastases, but it was not significantly correlated to the type of pathology and regional or distant metastases. Ablation activities exceeding 5.55 GBq produce no further increase in the accumulated activity per volume of blood. The literature regarding this issue is scarce, and further studies are required to verify these preliminary results.

journal_name

Health Phys

journal_title

Health physics

authors

Fatholahi L,Tabeie F,Pashazadeh AM,Javadi H,Assadi M,Asli IN

doi

10.1097/HP.0000000000000169

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

53-8

issue

1

eissn

0017-9078

issn

1538-5159

pii

00004032-201501000-00007

journal_volume

108

pub_type

杂志文章
  • Effectiveness of continuously infused DTPA therapy in reducing the radiation dose from inhaled 244Cm2O3 aerosols.

    abstract::Radionuclide decorporation is the only effective method of reducing radiation dose for persons contaminated accidentally. In this study, dogs that had inhaled a moderately soluble aerosol of 244Cm2O3 were treated with either discrete intravenous injections of the chelating agent diethylenetriaminepentaacetic acid (Zn-...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199204000-00002

    authors: Guilmette RA,Muggenburg BA

    更新日期:1992-04-01 00:00:00

  • Dose paradigms for inhaled vapors of primary carcinogens and their impact on risk assessment.

    abstract::In the assessment of risk, several factors affect predictions: selection of reactive agent, selection of tumor incidence data, modeling of dose, scaling across species, adjustment for differences in duration and frequency of exposure, and selection of the most suitable risk extrapolation model. If the endpoints, expos...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198907001-00046

    authors: Beliles RP,Parker JC

    更新日期:1989-01-01 00:00:00

  • A simple approximation for estimating centerline gamma absorbed dose rates due to a continuous Gaussian plume.

    abstract::A simple approximation for estimating the centerline gamma absorbed dose rates due to a continuous Gaussian plume was developed. To simplify the integration of the dose integral, this approach makes use of the Gaussian cloud concentration distribution. The solution is expressed in terms of the I1 and I2 integrals whic...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198708000-00004

    authors: Overcamp TJ,Fjeld RA

    更新日期:1987-08-01 00:00:00

  • Measurement of outdoor terrestrial gamma radiation in the Sultanate of Oman.

    abstract::The terrestrial gamma radiation level was determined throughout the Sultanate of Oman over a 3-y period. The dose rate at 1 m above the ground was measured at 512 locations using a compensated Geiger-Miller detector. The activity concentration of soil/rock samples, collected from 112 locations, was determined by gamma...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200206000-00016

    authors: Goddard CC

    更新日期:2002-06-01 00:00:00

  • Radiation protection and medical practice with special reference to health physicists and the Health Physics Society.

    abstract::This paper broadly examines the historical development of radiation protection in medical practice through an examination of the interactions of those concerned with radiation protection and medical practice with emphasis on the last half century and on the role played by health physicists and the Health Physics Socie...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-199511000-00014

    authors: Stannard JN,Kathren RL

    更新日期:1995-11-01 00:00:00

  • Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure: is There Evidence to Support a Reduction in Threshold Dose?

    abstract::Ionizing radiation exposure to the lens of the eye is a known cause of cataractogenesis. Historically, it was believed that the acute threshold dose for cataract formation was 5 Sv, and annual dose limits to the lens were set at 150 mSv. Recently, however, the International Commission on Radiological Protection has re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000810

    authors: Thome C,Chambers DB,Hooker AM,Thompson JW,Boreham DR

    更新日期:2018-03-01 00:00:00

  • The distribution of Thorotrast in human bone marrow: a case report.

    abstract::Samples of bone containing cellular and fatty bone marrow were removed at autopsy from the body of a woman who, following an automobile accident, had been injected with approximately 25 mL of the radiographic contrast medium Thorotrast. The woman survived for 36 y after the accident and died at age 72 y following bone...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199207000-00007

    authors: Priest ND,Humphreys JA,Kathren RL,Mays CW

    更新日期:1992-07-01 00:00:00

  • Comparison of sliced and whole lung sets for the LLNL and JAERI torso phantoms using GE detectors.

    abstract::The performance characteristics of sliced lung sets were compared to lung sets with activity homogeneously distributed throughout the lung tissue substitute material. The activity estimate from planar sources differs from the estimate from homogeneous sources by a factor of 0.88 to 1.09 depending on the photon energy....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199905000-00013

    authors: Kramer GH,Hauck BM,Lee TY,Chang SY

    更新日期:1999-05-01 00:00:00

  • Dose rates for several organs in a human from contaminated soil and hot particles using the QAD computer code.

    abstract::Dose rates from contaminated soil and hot particles have been calculated for several organs of a reference human. The calculation was performed using the computer code QAD-CGGP, a point kernel code employing combinatorial geometry for the representation of the human phantom. QAD uses buildup factors based on the geome...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199111000-00010

    authors: Tsoulfanidis N,Phillips K

    更新日期:1991-11-01 00:00:00

  • Use of alpha spectroscopy for conducting rapid surveys of transuranic activity on air sample filters and smears.

    abstract::This paper demonstrates the utility of a portable alpha Continuous Air Monitor (CAM) as a bench top scalar counter for multiple sample types. These include using the CAM to count fixed air sample filters and radiological smears. In counting radiological smears, the CAM is used very much like a gas flow proportional co...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000156959.35525.57

    authors: Hayes RB,Peña AM,Goff TE

    更新日期:2005-08-01 00:00:00

  • Twenty years of experience in monitoring 41Ar in a research reactor and decrease of its discharge into the environment.

    abstract::The radioactive gas 41Ar has been produced at high concentration by neutron activation near the reactor core in the Kyoto University Research Reactor. A pipe line for an exhaust stream, so-called sweep gas, was fabricated at the construction of the reactor in 1964 in order to exhale 41Ar from the facilities above to t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200404000-00008

    authors: Fukui M

    更新日期:2004-04-01 00:00:00

  • Measurements of 129I in human and bovine thyroids in Europe--transfer of 129I into the food chain.

    abstract::Bovine thyroid glands from different countries in Europe and human thyroid glands from Lower Saxony (Federal Republic of Germany) show isotopic 129I/127I ratios of 2.1 X 10(-9) to 8.2 X 10(-8) for cattle and 2.1 X 10(-9) to 8 X 10(-8) in humans. These values give information about the concentration of fallout 129I in ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199005000-00006

    authors: Handl J,Pfau A,Huth FW

    更新日期:1990-05-01 00:00:00

  • Estimating thyroid masses for children, infants, and fetuses in Ukraine exposed to (131)I from the Chernobyl accident.

    abstract::For the purpose of improving retrospective internal thyroid dose estimations for children and adolescents following the Chernobyl accident, age- and gender-dependent thyroid masses have been estimated for the children of Kiev and Zhytomyr oblasts, which are two of the most contaminated regions of Northern Ukraine. For...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31826e188e

    authors: Likhtarov I,Kovgan L,Masiuk S,Chepurny M,Ivanova O,Gerasymenko V,Boyko Z,Voillequé P,Antipkin Y,Lutsenko S,Oleynik V,Kravchenko V,Tronko M

    更新日期:2013-01-01 00:00:00

  • Uptake of 244Cm, 238Pu and other radionuclides by trees inhabiting a contaminated flood plain.

    abstract::The plant uptake of 244Cm, 137Cs, 238Pu and 90Sr was measured for trees in a flood plain forest whose soils were contaminated by aqueous discharges from a nuclear-fuel chemical separations facility. Uptake of the naturally occurring radionuclide 226Ra was also measured. The relative availability of the nuclides was 23...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198409000-00003

    authors: Pinder JE 3rd,McLeod KW,Alberts JJ,Adriano DC,Corey JC

    更新日期:1984-09-01 00:00:00

  • Uncertainty of (222)Rn concentrations in the usepa radiation and indoor environments National Laboratory Exposure Chamber.

    abstract::The U.S. Environmental Protection Agency (EPA) operates an environmentally controlled chamber for purposes of exposing various radon and decay product measurement equipment to known (222)Rn concentrations. Exposure durations range from 1 h to several months, and (222)Rn concentrations vary between 37 and 4,440 Bq m(-3...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182712e5a

    authors: Ronca-Battista M,Budd G,McLemore S

    更新日期:2013-02-01 00:00:00

  • Radionuclide export and elimination by coyotes at two radioactive waste disposal areas in southeastern Idaho.

    abstract::Coyote fecal samples were collected near a radioactive waste leaching pond and a solid radioactive waste disposal facility and analyzed for radioactivity. Elevated concentrations of 137Cs, 90Sr and 238Pu in the samples from the liquid radioactive waste leaching area were attributed to coyotes ingesting contaminated po...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198210000-00003

    authors: Arthur WJ 3rd,Markham OD

    更新日期:1982-10-01 00:00:00

  • Analysis of aerosol distribution inside the object "shelter" at the Chernobyl nuclear reactor site.

    abstract::Results of the aerosol sampling inside the Object Shelter at the Chornobyl nuclear reactor site are considered in the work. The results show a consistent and significant contribution of submicron fraction to the total aerosol activity. Different methods of interpretation of impactor data series are compared in order t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200108000-00005

    authors: Bondarenko OA,Aryasov PB,Melnichuk DV,Medvedev SY

    更新日期:2001-08-01 00:00:00

  • Improved confidence intervals when the sample is counted an integer times longer than the blank.

    abstract::Past computer solutions for confidence intervals in paired counting are extended to the case where the ratio of the sample count time to the blank count time is taken to be an integer, IRR. Previously, confidence intervals have been named Neyman-Pearson confidence intervals; more correctly they should have been named ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31820448c4

    authors: Potter WE,Strzelczyk JJ

    更新日期:2011-05-01 00:00:00

  • A comparison between gross and net count methods when searching for orphan radioactive sources.

    abstract::Different numerical strategies in searching for orphan radioactive sources in the environment by means of a mobile detector system have been evaluated. A carborne 3- by 3-inch NaI(Tl) spectrometric system was used with an unshielded 2 GBq 137Cs source as a test source. In this paper, a previous method (MB method), bas...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200302000-00008

    authors: Hjerpe T,Samuelsson C

    更新日期:2003-02-01 00:00:00

  • The Influence of Aerosol Density and Shape Factor on the Assessment of Internal Exposure to 239Pu.

    abstract::Internal exposure due to inhalation of aerosols depends on the ratio of aerodynamic shape factor (χ) to aerosol mass density (ρ). Inhaled aerosol parameters may differ from the default ρ and χ values provided by the International Commission on Radiological Protection, which are adopted for the assessment of internal e...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001052

    authors: Zhang B,Sheng W,Xu M,Zhang Y,Lei JY,Ma HC

    更新日期:2019-10-01 00:00:00

  • A study of amplifying the response of an LR115 solid state track detector by combining it with electret.

    abstract::Radon progeny are positively charged immediately after formation. A negatively charged electret collects radon progeny atoms which are produced in the diffusion chamber. The detector sensitivity may be increased by using an electret in front of solid state nuclear track detector. Dependence of detection sensitivity on...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199512000-00008

    authors: Nikezić D,Krstić D

    更新日期:1995-12-01 00:00:00

  • Immune Reconstitution and Thymic Involution in the Acute and Delayed Hematopoietic Radiation Syndromes.

    abstract::Lymphoid lineage recovery and involution after exposure to potentially lethal doses of ionizing radiation have not been well defined, especially the long-term effects in aged survivors and with regard to male/female differences. To examine these questions, male and female C57BL/6 mice were exposed to lethal radiation ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001352

    authors: Wu T,Plett PA,Chua HL,Jacobsen M,Sandusky GE,MacVittie TJ,Orschell CM

    更新日期:2020-11-01 00:00:00

  • Investigation of neutron scattering for a multisphere spectrometer.

    abstract::Count rates were measured as a function of distance from a planar concrete reflector for a set of eight Bonner-sphere detectors and four isotopic neutron sources. These data can be used to determine the contributions of scattered neutrons to the response of moderated detectors used in environments bounded by concrete....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199009000-00008

    authors: Sun RK

    更新日期:1990-09-01 00:00:00

  • The 42nd Lauriston S. Taylor Lecture: Radiation Dosimetry Research for Medicine and Protection-A European Journey.

    abstract::The assessment of doses related to exposures to ionizing radiation is an essential part of all applications of ionizing radiation including radiation medicine, radiation protection, radiation biology, radiation epidemiology, and also industrial uses of radiation. Absorbed dose is generally considered to be the fundame...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/HP.0000000000001023

    authors: Menzel HG

    更新日期:2019-02-01 00:00:00

  • Doses to patients from diagnostic radiology in France.

    abstract::Reported here are results of a 1982 national survey in France to establish the collective effective dose equivalent associated with the main types of radiological examinations practiced annually in this country (except nuclear medicine, C.T. scans, dental radiology and mass chest screening). This report describes the ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198804000-00002

    authors: Maccia C,Benedittini M,Lefaure C,Fagnani F

    更新日期:1988-04-01 00:00:00

  • A study of worker dose distributions with respect to ICRP dose limitation recommendations.

    abstract::This paper describes an investigation into the distribution of radiation doses to workers, undertaken at the request of ICRP Committee 4. Three main questions are considered. Firstly, the distribution of annual doses to workers is described. Doses are generally well below the ICRP dose limits and most are below 15 mSv...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198611000-00002

    authors: Johnston PD,Brenot J,Kendall GM

    更新日期:1986-11-01 00:00:00

  • Inter-species extrapolation of skin heating resulting from millimeter wave irradiation: modeling and experimental results.

    abstract::This study reports measurements of the skin surface temperature elevations during localized irradiation (94 GHz) of three species: rat (irradiated on lower abdomen), rhesus monkey (posterior forelimb), and human (posterior forearm). Two exposure conditions were examined: prolonged, low power density microwaves (LPM) a...

    journal_title:Health physics

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004032-200305000-00006

    authors: Nelson DA,Walters TJ,Ryan KL,Emerton KB,Hurt WD,Ziriax JM,Johnson LR,Mason PA

    更新日期:2003-05-01 00:00:00

  • A Simple Method to Screen for Radiostrontium in Water by Ion Exchange Chromatography.

    abstract::Radiostrontium isotopes (Sr, Sr, and Sr) are major fission by-products in nuclear reactors, in radiological events, and in environmental radioactive contamination. A method to analyze Sr and Sr in water has been developed using gradient elution with dilute hydrochloric acid and cation exchange resin, followed by carbo...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001020

    authors: Nguyen DM,Moody WA,Williamson JA

    更新日期:2019-06-01 00:00:00

  • Radiation dose implications of airborne contaminant deposition to humans.

    abstract::In nuclear accident consequence assessment, dose contributions from radionuclide deposition on the human body have in the past generally been either ignored or estimated on the basis of rather simple models. Recent experimental work has improved the state of knowledge of relevant processes and parameter ranges. The re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200202000-00007

    authors: Andersson KG,Fogh CL,Byrne MA,Roed J,Goddard AJ,Hotchkiss SA

    更新日期:2002-02-01 00:00:00

  • Collective biodosimetry as a dosimetric "gold standard": a study of three radiation accidents.

    abstract::Quantification of the biologically relevant dose is required for the establishment of cause-and-effect between radiation detriment or burden and important biological outcomes. Most epidemiological studies of unanticipated radiation exposure fail to establish cause and effect because of an inability to construct a vali...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199703000-00006

    authors: Pass B,Baranov AE,Kleshchenko ED,Aldrich JE,Scallion PL,Gale RP

    更新日期:1997-03-01 00:00:00