Abstract:
:Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na(+) to enter and be used as substrate for cation/proton antiporters responsible for cytoplasmic pH homeostasis. Here, we describe a new member of the prokaryotic voltage-gated Na(+) channel family (NsvBa;
journal_name
Elifejournal_title
eLifeauthors
DeCaen PG,Takahashi Y,Krulwich TA,Ito M,Clapham DEdoi
10.7554/eLife.04387subject
Has Abstractpub_date
2014-11-11 00:00:00issn
2050-084Xjournal_volume
3pub_type
杂志文章相关文献
eLife文献大全abstract::Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly exerts its function as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage leading to conformation...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08887
更新日期:2015-12-17 00:00:00
abstract::Learning to perform a complex motor task requires the optimization of specific behavioral features to cope with task constraints. We show that when mice learn a novel motor paradigm they differentially refine specific behavioral features. Animals trained to perform progressively faster sequences of lever presses to ob...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09423
更新日期:2015-09-29 00:00:00
abstract::Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01926
更新日期:2013-12-31 00:00:00
abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneou...
journal_title:eLife
pub_type: 杂志文章,多中心研究
doi:10.7554/eLife.15085
更新日期:2017-01-09 00:00:00
abstract::Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some macrophages persist in the absence of CSF1R. Here, we analyzed mpeg1:GFP-expressing macrophages in csf1r-deficient zebrafish and report that embryonic macrophages emerg...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53403
更新日期:2020-05-05 00:00:00
abstract::Multi-modal MRI techniques have identified biomarkers that could help to predict whether someone will develop epilepsy. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.29853
更新日期:2017-07-26 00:00:00
abstract::Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrophages is highly con...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50414
更新日期:2019-10-14 00:00:00
abstract:: ...
journal_title:eLife
pub_type: 已发布勘误
doi:10.7554/eLife.65214
更新日期:2020-12-04 00:00:00
abstract::One of the major unanswered questions in evolutionary biology is when and how the transition between diderm (two membranes) and monoderm (one membrane) cell envelopes occurred in Bacteria. The Negativicutes and the Halanaerobiales belong to the classically monoderm Firmicutes, but possess outer membranes with lipopoly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14589
更新日期:2016-08-31 00:00:00
abstract::Manipulating gene function cell type-specifically is a common experimental goal in Drosophila research and has been central to studies of neural development, circuit computation, and behavior. However, current cell type-specific gene disruption techniques in flies often reduce gene activity incompletely or rely on cel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22279
更新日期:2017-02-17 00:00:00
abstract::The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the peer-reviewed literature) abou...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57309
更新日期:2020-04-02 00:00:00
abstract::Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays. We purified N-terminally tagged recombinant Wnt3a secreted from cells and accidenta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11621
更新日期:2016-02-23 00:00:00
abstract::Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43079
更新日期:2019-05-21 00:00:00
abstract::The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is a link between developmental programs and the emergence of inborn behaviors remains unknown. Our previous studies revealed that the telencephalic preoptic area (POA) embr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21012
更新日期:2017-03-13 00:00:00
abstract::When a plant cell divides, four related proteins control the trafficking of vesicles and ensure that cargo that is normally recycled to the plasma membrane is instead re-routed to the plane of cell division. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.02747
更新日期:2014-04-08 00:00:00
abstract::The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium release. Here, we report that the zebrafish/human phosphatidylinosit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26362
更新日期:2017-05-02 00:00:00
abstract::Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling and cell division. We show that mechanical strain induced Src-depe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19799
更新日期:2016-10-26 00:00:00
abstract::We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58042
更新日期:2020-08-24 00:00:00
abstract::Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10230
更新日期:2015-11-14 00:00:00
abstract::Although mRNAs are localized in the processes of excitatory neurons, it is still unclear whether interneurons also localize a large population of mRNAs. In addition, the variability in the localized mRNA population within and between cell types is unknown. Here we describe the unbiased transcriptomic characterization ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63092
更新日期:2021-01-06 00:00:00
abstract::Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59587
更新日期:2020-06-10 00:00:00
abstract::Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54095
更新日期:2020-05-11 00:00:00
abstract::Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28080
更新日期:2017-06-13 00:00:00
abstract::β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49853
更新日期:2019-10-15 00:00:00
abstract::Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58593
更新日期:2020-10-22 00:00:00
abstract::Translation is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome. There has been remarkable evolutionary adaptation of this machine through the addition of eukaryote-specific ribosomal proteins whose individual effects on ribosome function are largely unknown. Here we show ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11154
更新日期:2016-04-27 00:00:00
abstract::Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the acti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49315
更新日期:2019-11-01 00:00:00
abstract::Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in part been limit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25174
更新日期:2017-05-19 00:00:00
abstract::Journals and other scientific organizations produce a diverse variety of plain-language summaries. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25411
更新日期:2017-03-15 00:00:00
abstract::WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain protein...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49439
更新日期:2019-09-05 00:00:00