Abstract:
:The mechanism underlying immune system recognition of different types of pathogens has been extensively studied over the past few decades; however, the mechanism by which healthy self-tissue evades an attack by its own immune system is less well-understood. Here, we established an autoimmune model of melanotic mass formation in Drosophila by genetically disrupting the basement membrane. We found that the basement membrane endows otherwise susceptible target tissues with self-tolerance that prevents autoimmunity, and further demonstrated that laminin is a key component for both structural maintenance and the self-tolerance checkpoint function of the basement membrane. Moreover, we found that cell integrity, as determined by cell-cell interaction and apicobasal polarity, functions as a second discrete checkpoint. Target tissues became vulnerable to blood cell encapsulation and subsequent melanization only after loss of both the basement membrane and cell integrity.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Kim MJ,Choe KMdoi
10.1371/journal.pgen.1004683subject
Has Abstractpub_date
2014-10-16 00:00:00pages
e1004683issue
10eissn
1553-7390issn
1553-7404pii
PGENETICS-D-14-00776journal_volume
10pub_type
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