D‑galactose‑induced mitochondrial DNA oxidative damage in the auditory cortex of rats.

abstract：:In the present study, a novel polysaccharide, APS2-1, was isolated and purified from Astragalus membranaceus using DEAE-cellulose and Sephadex G-100 chromatography. The effect of APS2‑1 on the promotion of wound healing was evaluated and its preliminary mechanism was investigated. In vitro experiments showed that APS2...

journal_title：Molecular medicine reports

authors： Zhao B,Zhang X,Han W,Cheng J,Qin Y

更新日期：2017-06-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury is a major pathological process in coronary heart disease and cardiac surgery, and is associated with aberrant microRNA (miR) expression. Previous studies have demonstrated that inhibition of miR-15a expression may ameliorate I/R‑induced myocardial injury. In the present st...

journal_title：Molecular medicine reports

authors： Yang Y,Ding S,Xu G,Chen F,Ding F

更新日期：2017-06-01 00:00:00

abstract：:Circular RNAs (circRNAs) are non-coding RNAs forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In the pr...

journal_title：Molecular medicine reports

authors： Zhang Y,Ke X,Liu J,Ma X,Liu Y,Liang D,Wang L,Guo C,Luo Y

更新日期：2019-01-01 00:00:00

abstract：:The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation fr...

journal_title：Molecular medicine reports

authors： Shu J,Liu Z,Jin L,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was determined. The quantitative polymerase chain reaction results demonstrated...

journal_title：Molecular medicine reports

authors： Lu M,Xu L,Wang M,Guo T,Luo F,Su N,Yi S,Chen T

更新日期：2018-06-01 00:00:00

abstract：:Alpinetin is a natural flavonoid widely distributed in Zingiberaceae. Previous studies have demonstrated that alpinetin markedly inhibits tumour growth. However, the molecular mechanisms underlying the antitumour effects of alpinetin are unclear. Bcl‑2‑associated X protein (Bax) tra...

journal_title：Molecular medicine reports

authors： Wang Z,Lu W,Li Y,Tang B

更新日期：2013-03-01 00:00:00

abstract：:Induction of cardiomyocyte proliferation, the most promising approach to reverse myocardial attrition, has been gaining importance as a therapy for cardiovascular disease. Hypoxia and macrophages were previously independently reported to promote cardiomyocyte proliferation in mice. However, whether hypoxia promotes ca...

journal_title：Molecular medicine reports

authors： Liu B,Zhang HG,Zhu Y,Jiang YH,Luo GP,Tang FQ,Jian Z,Xiao YB

更新日期：2017-06-01 00:00:00

abstract：:Dendritic cells, the most powerful type of antigen‑presenting cells, have the unique ability to induce primary immune responses. Connexin43 expression is upregulated to increase gap junctions when immune cells are exposed to inflammatory factors. The present study applied small‑interfering RNA (siRNA) to decrease conn...

journal_title：Molecular medicine reports

authors： Yu F,Yan H,Nie W,Zhu J

更新日期：2016-01-01 00:00:00

abstract：:An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

journal_title：Molecular medicine reports

authors： Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

更新日期：2018-04-01 00:00:00

abstract：:While most cancer types are resistant to mammalian target of rapamycin complex 1 (mTORC1) inhibitor rapamycin, recent studies have identified mTORC2 as an important prospective therapeutic target for cancer. The present study assessed the effects of mTORC2 inhibitor PP242 on the proliferation and migration of bladder ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhang G,Kong C,Gong D

更新日期：2016-01-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:The purpose of the present study was to evaluate distinct metabolic features of meningiomas to distinguish them from other brain lesions using proton magnetic resonance spectroscopy. The study was performed on 17 meningiomas, 24 high-grade gliomas and 9 metastases. Elevated signal intensity at 3.8 ppm observed in low ...

journal_title：Molecular medicine reports

authors： Kousi E,Tsougos I,Fountas K,Theodorou K,Tsolaki E,Fezoulidis I,Kapsalaki E

更新日期：2012-04-01 00:00:00

abstract：:Studies using animal models have demonstrated that probiotics may have a beneficial role in the prevention of colorectal cancer (CRC); however, the underlying mechanism of the beneficial effects of interventional probiotic treatment on gut microbiota has remained elusive. In the present study, pyrosequencing of the V3...

journal_title：Molecular medicine reports

authors： Gao Z,Guo B,Gao R,Zhu Q,Wu W,Qin H

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal ce...

journal_title：Molecular medicine reports

authors： Zhang ZH,Wu LN,Song JG,Li WQ

更新日期：2012-10-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of myricetin on reducing cerebral ischemia injury in a rat model. A rat model of permanent middle cerebral artery occlusion (pMCAO) was used in the present study. Rats were randomized into the following five groups: Sham, model, low‑myricetin (1 mg/kg), mediu...

journal_title：Molecular medicine reports

authors： Sun L,Xu P,Fu T,Huang X,Song J,Chen M,Tian X,Yin H,Han J

更新日期：2018-02-01 00:00:00

abstract：:Numerous studies have demonstrated that pseudolaric acid B (PAB) promotes apoptosis in several cancer cell lines. However, thus far, the effect of PAB on human leukemia cells has not been evaluated. In the present study, the antitumor activity and molecular mechanisms of PAB in human leukemia U937 cells were investiga...

journal_title：Molecular medicine reports

authors： Wang JH,Kan L,Shu LH,Wang N,Li NJ,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to investigate the hypotheses that cytomegalovirus (CMV) may trigger idiopathic pulmonary fibrosis (IPF) in a susceptible host and/or that the presence of CMV may alter IPF in response to a well-defined trigger of pulmonary fibrosis. A mouse model of murine CMV (MCMV) infection was est...

journal_title：Molecular medicine reports

authors： Li Y,Gao J,Wang G,Fei G

更新日期：2016-08-01 00:00:00

abstract：:Activin receptor‑like kinases (ALKs), members of the type I activin receptor family, belong to the serine/threonine kinase receptors of the transforming growth factor‑β (TGF‑β) superfamily. ALKs mediate the roles of activin/TGF‑β in a wide variety of physiological and pathological processes, ranging from cell differen...

journal_title：Molecular medicine reports

authors： Cui X,Shang S,Lv X,Zhao J,Qi Y,Liu Z

更新日期：2019-06-01 00:00:00

abstract：:Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC). Despite an initial response to therapy, resistance to irinotecan reduces its efficacy. We isolated irinotecan-resistant human NSCLC A549 cells, termed A549/CTP-11R cells. A549/CTP-11R c...

journal_title：Molecular medicine reports

authors： Ikeda R,Vermeulen LC,Lau E,Jiang Z,Pomplun M,Kolesar JM

更新日期：2010-11-01 00:00:00

abstract：:Hepatic glycoprotein (gp78), a membrane-anchored E3 ubiquitin ligase, has been reported to be involved in regulating lipid and energy metabolism in animals, and cell death‑inducing DFFA‑like effector c (cidec) has emerged as an important regulator of metabolism, which has been implicated in the process of fat differen...

journal_title：Molecular medicine reports

authors： Li J,Liu G,Zhang F,Zhang Z,Xu Y,Li Q

更新日期：2017-08-01 00:00:00

abstract：:Quantitative polymerase chain reaction (qPCR) analysis is a commonly used method for the study of mRNA expression throughout the field of mesenchymal stem cell (MSC) research. This technology is simple and sensitive; however the results may vary significantly due to the use of various reference genes (RGs) as normaliz...

journal_title：Molecular medicine reports

authors： Li X,Yang Q,Bai J,Yang Y,Zhong L,Wang Y

更新日期：2015-02-01 00:00:00

abstract：:Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (I/R) and is a major contributing factor to its high mortality rate. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell life...

journal_title：Molecular medicine reports

authors： Zhang F,Li ZL,Xu XM,Hu Y,Yao JH,Xu W,Jing HR,Wang S,Ning SL,Tian XF

更新日期：2015-01-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:S100 calcium binding protein A16 (S100A16) is the most recent member of the S100 calcium-binding protein family. The function of S100A16 has been associated with various types of cancer; however, its role in colorectal cancer (CRC) remains unknown. Therefore, the aim of the present study was to investigate the role of...

journal_title：Molecular medicine reports

authors： Ou S,Liao Y,Shi J,Tang J,Ye Y,Wu F,Wang W,Fei J,Xie F,Bai L

更新日期：2021-02-01 00:00:00

abstract：:The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy‑associated cellular apoptosis. A total of 40 Sprague Dawley (SD) rats were used as a diabetic retinopathy model following injection with streptozotocin. Among the 34 rats in which the diabetes model was s...

journal_title：Molecular medicine reports

authors： Wu Y,Chen Y,Wu Q,Jia L,Du X

更新日期：2015-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:The present study aimed to investigate genes and transcription factors (TFs) that may contribute to neuroblastoma (NB) development. The GSE78061 dataset that included 25 human NB cell lines and four retinal pigment epithelial cell lines was used to analyze differentially expressed genes (DEGs) between groups. Function...

journal_title：Molecular medicine reports

authors： Liu J,Li Y

更新日期：2019-10-01 00:00:00

abstract：:Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), the outcome of T‑ALL treatment remains unsatisfactory, therefore, more effective treatment is urgently required. The present study examined the cytotoxicities of bortezomib in combination with daunorubicin against human Jurkat and Molt‑4...

journal_title：Molecular medicine reports

authors： Du X,Tong J,Lu H,He C,Du S,Jia P,Zhao W,Xu H,Li J,Shen Z,Wu Y,Tong J,Zhou L

更新日期：2017-07-01 00:00:00