Abstract：
BACKGROUND:Pain clinicians have always been challenged by the variability of response to pain treatment. Differences in the degree of pain stimulation and pain sensitivity, weight and age differences, prior opioid use and tolerance, as well as the differences in bioavailability of various opioid formulations have been cited as causes for the wide variability in analgesia seen with opioids. Genetics may explain the variability of responses and help to predict more effective (or less dangerous) medication choices and doses. Genetics may also help to predict the response to specific opioids and antidepressants. OBJECTIVES:In this review article, we discuss the genetic influence of nociception, analgesia, and hyoanalgesia. The CYP450 enzymes involved in the metabolism and activity of opioids and adjuvant analgesics are genetically controlled, as are the opioid receptors and a variety of brain chemistries. METHODS:This article discusses the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A7, OPRM1, OPRK1, OPRD1, COMT, GABA, UGT, MC1R, GCH1, ABCB1, P-glycoprotein, 5HTR1A, 5HTR2A, MTHFR, CACNA2D2, and 5-HTTLPR. RESULTS:Recent research findings suggest the relationship between genetic predisposition and clinical behavior, including the risk of opioid misuse and addiction. While urine drug testing may hint at genetic issues regarding opioid metabolism, cheek swab DNA testing has become economically viable, and we review the current and future genetic pain issues that may influence the decisions that pain clinicians make every day. CONCLUSION:Genetic testing may explain and predict many of the clinical responses seen with opioids and adjuvant medications, and may help the clinician identify those patients at genetic risk of opioid misuse and addiction.
journal_name
Pain Physicianjournal_title
Pain physicianauthors
Trescot AM,Faynboym Ssubject
Has Abstractpub_date
2014-09-01 00:00:00pages
425-45issue
5eissn
1533-3159issn
2150-1149journal_volume
17pub_type
杂志文章,评审相关文献
Pain Physician文献大全abstract：:Strategy formation involves understanding the environment and strengths and weaknesses of a practice to develop a game plan to achieve goals. It starts with the creation of a mission statement that defines a long-term vision of what the practice seeks to be and the markets it seeks to serve. Once the mission of the pr...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Hypersensitivity of the central nervous system to environmental and chemical stimuli is a clinical feature of central sensitization mechanisms that can be assessed with the central sensitization inventory (CSI). OBJECTIVE:The aim was to determine prevalence rate of this feature and explore the treatment-, p...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Opioids are used extensively for chronic pain management in the United States. The frequency of opioid use prior to presenting to interventional pain management settings and in interventional pain management settings has been shown to be above 90%. Opioid abuse has been demonstrated in 9% to 41% of patients ...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Epidural injection of corticosteroids is one of the most commonly used interventions in managing chronic spinal pain. However, there has been a lack of well-designed randomized, controlled studies to determine the effectiveness of epidural injections. Consequently, debate continues as to the value of epidura...
journal_title：Pain physician
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Transforaminal epidural steroid injection (TFESI) can be administered with or without sedation in clinical practice. OBJECTIVES:The aim of this study was to compare both procedures in terms of patient and physician satisfaction, preoperative anxiety level, procedural pain level, and complications. STUDY DE...
journal_title：Pain physician
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Hemiplegic shoulder pain is one of the most common complications after stroke. Although there are many treatment strategies for this complication, sometimes very resistant cases are also seen. OBJECTIVES:To evaluate the effect of suprascapular nerve pulsed radiofrequency (PRF) treatment for hemiplegic shoul...
journal_title：Pain physician
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:The trends of the expenditures of facet joint interventions have not been specifically assessed in the fee-for-service (FFS) Medicare population since 2009. OBJECTIVE:The objective of this investigation is to assess trends of expenditures and utilization of facet joint interventions in FFS Medicare populati...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:It has been generally recommended that platelet function may recover after the recommended 5-day discontinuation period prior to operation. The technique of thromboelastography has been demonstrated to monitor intraoperative platelet function in liver transplantation and coronary bypass surgery. However, the...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Epidural steroid injections are commonly used for chronic spinal pain. However, there is no conclusive evidence regarding their effectiveness, and debate continues as to their value in managing chronic spinal pain. OBJECTIVE:To evaluate various types of epidural injections (interlaminar, transforaminal, and...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Chronic smokers show differences in pain sensitivity compared to healthy non-smokers. Yet, no study to date has examined whether smoker status has an effect on postoperative pain. OBJECTIVE:We aim to examine a possible correlation between preoperative smoking and postoperative opioid dose based on the hypot...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Sacroiliac joint (SIJ) pathology is a common etiologic cause for 10 - 27% of cases of mechanical low back pain (LBP) below the L5 level. In the absence of definite clinical or radiologic diagnostic criteria, controlled blocks of the SIJ have become the choice assessment method for making the diagnosis of SIJ pain. The...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Professional and pre-professional musicians are characterized by physical and psychological demands inherent to their musical activity, and therefore at risk for developing performance related musculoskeletal pain. Physical and psychological demands are known to influence human pain modulation. OBJECTIVES:I...
journal_title：Pain physician
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Conventional open surgical procedures may cause massive dissections of the spine, higher perioperative complications, prolonged hospitalization, protracted rehabilitation programs and recovery. Percutaneous endoscopic lumbar interbody fusion (PELIF) is an evolving treatment option. OBJECTIVES:To present the...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Appropriate diagnosis is essential in providing proper and effective therapy. The field of diagnostic accuracy tests is dynamic with new tests being developed at a fast pace along with improvement in technology of existing tests on a continuous basis. Well-designed diagnostic test accuracy studies can help in making a...
journal_title：Pain physician
pub_type： 杂志文章,评审
doi：
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Liposomal bupivacaine (LipoB), delivered via intercostal nerve blocks (ICNBs), is increasingly being used for postoperative pain control in thoracic surgery patients, but there is limited data on its effectiveness when compared to standard bupivacaine. OBJECTIVE:We sought to compare postoperative opioid use...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:The management of chronic pain is a complex challenge worldwide. Cannabis-based medicines (CBMs) have proven to be efficient in reducing chronic pain, although the topic remains highly controversial in this field. OBJECTIVES:This study's aim is to conduct a conclusive review and meta-analysis, which incorpo...
journal_title：Pain physician
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Interventional pain physicians commonly encounter patients with a treatment refractory "chronic pain syndrome". Such patients have a chronically painful medical disorder that is complicated by a number of psychosocial factors, including psychiatric and substance use disorders, physical deconditioning, depend...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Pain medicine practices vary across different regions within a country and between countries. OBJECTIVES:The objective of the survey was to study the variation in interventional pain medicine practices in the United Kingdom (UK) and the United States (US). METHODS:A survey was designed in 2019 on Survey Mo...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The increase in the utilization of various techniques in managing chronic pain, including interventional techniques, is a major concern for policy-makers and the public at large. Consequently, multiple regulations have been instituted to reduce health care expenditures in general and expenditures related to ...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Facet joint pain is a common cause of low back pain. There are no physical exam findings that provide a reliable diagnosis. Diagnosis is made by medial branch block injections (MBB). Once the source of pain has been determined, radiofrequency neurotomy (RFN) can be performed. Previous studies have shown that...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Throughout the COVID-19 pandemic, clinicians have had to think quickly, adapt to changing recommendations sometimes on a daily basis, and have often had to rely on trial-and-error-based treatment protocols under various conditions. As we move on past the apex of the COVID-19 curve, new treatment protocols fo...
journal_title：Pain physician
pub_type： 杂志文章,评审
doi：
更新日期：2020-08-01 00:00:00
abstract：:Appropriate documentation, billing and coding in interventional pain practice is a crucial issue with a wide arena of regulatory reforms. There have been reports of billions of dollars in losses in health care fraud. Office of Inspector General reports a massive war on health fraud. Substantial savings from prepayment...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Post-dural puncture headache (PDPH) is the most common complication of procedures in which the dura mater is penetrated. OBJECTIVES:To evaluate the effectiveness of caudal saline injections as a therapeutic approach for handling post-dural puncture headache. STUDY DESIGN:Prospective observational study bet...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Individual response to opioid analgesics varies among patients. OBJECTIVE:This study sought to clarify the impact of distinct genetic variations on pain, opioid consumption, and opioid side effects in patients with postoperative pain. STUDY DESIGN:A systematic review and meta-analysis of associations betwe...
journal_title：Pain physician
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Orofacial pain, headaches, and neck pain are very common pain conditions in the general population and might be associated in their pathophysiology, although this is not yet clarified. The development and validation of a prediction inventory is important to minimize risks. Most recent questionnaires have not...
journal_title：Pain physician
pub_type： 杂志文章,多中心研究
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Compared to an abundance of data on surgical techniques for degenerative spine conditions and the outcomes thereof, little is available to guide optimal perioperative pain management after spinal surgery. The aim of this study was to survey patterns of perioperative pain management after spinal surgery and t...
journal_title：Pain physician
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-05-01 00:00:00
abstract：:This study was designed to evaluate psychological status of 150 individuals; 50 without chronic pain and without psychotherapeutic drug therapy, Group I or control group; 50 patients with chronic pain, Group II, chronic pain group with involvement of one region; and 50 chronic pain patients with involvement of two or ...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：:Spinal Cord Stimulation (SCS) is a treatment option for chronic pain patients. Spinal cord stimulation has been employed in the treatment of chronic pain for more than 30 years. The most common indication for SCS is the failed back syndrome with leg pain. Its indications have expanded beyond back and lower extremities...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:When spinal injections are performed, a needle is placed in or around the spine making the risk of complications unavoidable. Spinal structures or adjacent organs are at risk for direct needle trauma, infection, hematoma, hemorrhage, nerve damage, stroke, allergic reaction, or spinal anesthesia with cardiorespiratory ...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:Proper coding and documentation for evaluation and management services continuously and progressively are becoming not only complicated, but also confusing. Although medical evaluation of patients has been a fact of life since the beginnings of medical history, medicine has been substantially influenced by federal reg...
journal_title：Pain physician
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
