Outcomes and management strategies for graft failure after umbilical cord blood transplantation.

Abstract:

:Graft failure is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Graft failure is more prevalent after umbilical cord blood transplantation (UCBT) compared with conventional adult stem cell sources. We identified 21 consecutive patients who experienced graft failure after UCBT at our center between 2004 and 2013 and describe their treatment strategies and outcomes. Two patients experienced early death. Seven patients had return of autologous hematopoiesis including 1 patient who was given previously collected autologous stem cells. Twelve patients received a second early HSCT, six from separate UCB units and six from a haploidentical donor. With a median follow-up of 33.2 months for surviving patients, 3-year PFS is 23% and 3-year OS is 37%. Of the six long-term survivors without relapse, four received a second HSCT from a haploidentical donor with post-HSCT high-dose cyclophosphamide based GVHD prophylaxis. This strategy appears safe and merits further investigation in this setting.

journal_name

Am J Hematol

authors

Singh H,Nikiforow S,Li S,Ballen KK,Spitzer TR,Soiffer R,Antin JH,Cutler C,Chen YB

doi

10.1002/ajh.23845

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1097-101

issue

12

eissn

0361-8609

issn

1096-8652

journal_volume

89

pub_type

杂志文章
  • Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.

    abstract::Drug metabolizing genes are involved in the detoxification of chemical carcinogens. Polymorphisms in drug-metabolizing genes affect the risk of some forms of cancer. We analyzed six polymorphisms to evaluate their association with risk for non-Hodgkin lymphoma (NHL), and to examine whether smoking modifies these assoc...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21556

    authors: Kim HN,Kim NY,Yu L,Kim YK,Lee IK,Yang DH,Lee JJ,Shin MH,Park KS,Choi JS,Kim HJ

    更新日期:2009-12-01 00:00:00

  • Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia.

    abstract::In a pilot study to reduce the duration of treatment and potential long-term toxicities, 39 patients with acute promyelocytic leukemia in remission received a single cycle of intensive consolidation therapy, followed by intermittent ATRA maintenance. Consolidation therapy required prolonged hospitalization and was ass...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20354

    authors: Gore SD,Smith BD,Gojo I,Grever M,Kaufmann SH,Letendre L,Leonard DG,Marcucci G,Miller CB,Morris L,Piantadosi S,Prior T,Stock W,Karp JE

    更新日期:2005-06-01 00:00:00

  • Cytokine profile of sickle cell disease in Oman.

    abstract::The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients in steady state and in vaso-occlusive crisis (VOC). VOC has a complex nature, involving interactions between sickle red blood cells (RBC), the endothelium, and leucocytes. Endothelial damage due to recurrent adhesion of sickl...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20196

    authors: Pathare A,Al Kindi S,Alnaqdy AA,Daar S,Knox-Macaulay H,Dennison D

    更新日期:2004-12-01 00:00:00

  • Familial type II protein C deficiency associated with warfarin-induced skin necrosis and bilateral adrenal hemorrhage.

    abstract::A family is described in which venous thromboembolic disease is associated with reduced plasma protein C activity and normal levels of protein C antigen. Immunoelectrophoretic analysis of protein C antigen gave an abnormal pattern in all affected members, suggesting that the disorder is related to the presence of a st...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830290410

    authors: Conlan MG,Bridges A,Williams E,Marlar R

    更新日期:1988-12-01 00:00:00

  • Rearrangement and expression of MDM2 oncogene in chronic lymphocytic leukemia.

    abstract::Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM2 has been mapped to this chromosome, we examined the possible association of MDM2 in the pathogenesis of CLL. A rearrangement of the MDM2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Sout...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830470215

    authors: Huang YQ,Raphael B,Buchbinder A,Li JJ,Zhang WG,Friedman-Kien AE

    更新日期:1994-10-01 00:00:00

  • Sickle cell anemia as a syndrome: a review of diagnostic features.

    abstract::Sickle cell (SS) disease is a complex of various genetic conditions. In some, homozygosity for the beta S gene may be present alone or in combination with the heterozygous or homozygous alpha-thalassemia-2 condition. Such combinations might ameliorate the clinical and hematological condition of the patient. The same m...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.2830060210

    authors: Huisman TH

    更新日期:1979-01-01 00:00:00

  • Intensive short-term chemotherapy regimen induces high remission rate (over 90%) and event-free survival both in children and adult patients with advanced sporadic Burkitt lymphoma/leukemia.

    abstract::The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients-46 adults, 25 children-affected by Burkitt lymphoma/leukemia were tr...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.22189

    authors: Todeschini G,Bonifacio M,Tecchio C,Balter R,Carli G,Stefani PM,Adami F,Zamò A,Dei Tos AP,Marino F,Gherlinzoni F,Marradi P,Semenzato G,Pizzolo G

    更新日期:2012-01-01 00:00:00

  • Prognostic factors for therapeutic outcome of diffuse small non-cleaved cell lymphoma in adults.

    abstract::Most reports of prognosis and therapy in diffuse small non-cleaved cell lymphoma (DSNCL), an aggressive high-grade non-Hodgkin's lymphoma (NHL) which appears to be of two histopathologic subtypes, have included predominantly a pediatric population and very few adults. We studied 20 newly diagnosed, previously untreate...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830460408

    authors: Morrison VA,Frizzera G,Arthur DC,Ogle KM,Hurd DD,Bloomfield CD,Peterson BA

    更新日期:1994-08-01 00:00:00

  • Severe thrombotic tendency associated with a type I plasminogen deficiency.

    abstract::We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, elect...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830300107

    authors: Leebeek FW,Knot EA,Ten Cate JW,Traas DW

    更新日期:1989-01-01 00:00:00

  • Ultrasound-guided fine needle biopsy of the spleen: high clinical efficacy and low risk in a multicenter Italian study.

    abstract::The aim of this study was to evaluate the clinical efficacy and safety of the ultrasound-guided fine needle biopsy (UG-FNB) of the spleen in a large population of patients. We collected retrospectively the findings concerning the application of UG-FNB of the spleen from eight Italian clinical centers that utilized thi...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ajh.1085

    authors: Civardi G,Vallisa D,Bertè R,Giorgio A,Filice C,Caremani M,Caturelli E,Pompili M,De Sio I,Buscarini E,Cavanna L

    更新日期:2001-06-01 00:00:00

  • The use of ATG abrogates the antileukemic effect of cytomegalovirus reactivation in patients with acute myeloid leukemia receiving grafts from unrelated donors.

    abstract::Several studies provided evidence of a consistent antileukemic effect induced by cytomegalovirus (CMV) replication in acute myeloid leukemia (AML) patients receiving allogeneic hematopoietic stem cell transplantation (HSCT), however the use of antithymocyte globulin (ATG) as graft-versus-host disease prophylaxis, may ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23998

    authors: Busca A,Passera R,Pini M,Zallio F,Dellacasa C,Audisio E,Giaccone L,Maffini E,Costa C,Cavallo R,Bruno B

    更新日期:2015-06-01 00:00:00

  • Concurrent presentation of erythrocytic and megakaryocytic aplasia.

    abstract::A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-8652(199601)51:1<68::AID-AJH11>

    authors: Canavan BF,Huhn RD,Kim HC,Kosmin M,Sheay W,Saidi P

    更新日期:1996-01-01 00:00:00

  • Erythrocyte pyruvate kinase deficiency: a kinetic method for differentiation between heterozygosity and compound-heterozygosity.

    abstract::The goal of the present study was to search for criteria that allow one to distinguish between normal individuals and heterozygotes as well as compound heterozygotes for pyruvate kinase (PK) deficiency. As the residual activity of PK with heterozygotes was between 35% and 110% of the normal activity, it was necessary ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830310402

    authors: Lakomek M,Winkler H,Linne S,Schröter W

    更新日期:1989-08-01 00:00:00

  • Chronic lymphocytic leukemia: Time to go past genomics?

    abstract::Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biolog...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.24301

    authors: Roos-Weil D,Nguyen-Khac F,Bernard OA

    更新日期:2016-05-01 00:00:00

  • Sustained remissions and low rate of BCR-ABL resistance mutations with imatinib treatment chronic myelogenous leukemia in patients treated in late chronic phase: a 5-year follow up.

    abstract::The introduction of Imatinib (IM) has significantly altered the treatment for CML, although only limited follow-up results are available. As failure of Interferon-alpha had been associated with poor prognosis and results of IM-treatment in this patient group may allow earlier estimation of long-term benefits for early...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21055

    authors: Hess G,Meyer RG,Schuch B,Bechthold K,El-Kholy I,Huber C

    更新日期:2008-03-01 00:00:00

  • Change of enzyme properties caused by cross-linking treatment of human erythrocytes.

    abstract::Aragon et al [4] reported that rat erythrocytes can be cross-linked and permeabilized without significant inactivation or alterations of several enzymes in the glycolytic pathway. If this is the case, in situ kinetic analysis of the red cell enzymes in normal human red cells and abnormal red cells associated with hemo...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830130103

    authors: Ikawa M,Yoshida A

    更新日期:1982-08-01 00:00:00

  • A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia.

    abstract::Regulatory T-cells (Tregs) are increased in chronic lymphocytic leukemia(CLL) and correlates with clinical and biological features of active/progressive disease. However, little is known about their ability to predict the time to first treatment (TFT). We evaluated 75 patients with Rai stage 0 CLL, in whom the absolut...

    journal_title:American journal of hematology

    pub_type: 信件

    doi:10.1002/ajh.23170

    authors: D'Arena G,D'Auria F,Simeon V,Laurenti L,Deaglio S,Mansueto G,Del Principe MI,Statuto T,Pietrantuono G,Guariglia R,Innocenti I,Martorelli MC,Villani O,De Feo V,Del Poeta G,Musto P

    更新日期:2012-06-01 00:00:00

  • Drug-associated agranulocytosis: 20 years of reporting in The Netherlands (1974-1994).

    abstract::In this descriptive study, all 425 reports were included concerning drug-associated agranulocytosis as registered between 1974 and 1994 in the files of the Drug Safety Unit of the Dutch Inspectorate for Health Care. All reports were analysed as to the probability of agranulocytosis or neutropenia according to previous...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199803)57:3<206::aid-ajh4>

    authors: van der Klauw MM,Wilson JH,Stricker BH

    更新日期:1998-03-01 00:00:00

  • The effect of acute and chronic leukapheresis on the natural killer (NK) cell function of normal human volunteers.

    abstract::Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830220203

    authors: Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

    更新日期:1986-06-01 00:00:00

  • Dissociation between the level of von Willebrand factor-cleaving protease activity and disease in a patient with congenital thrombotic thrombocytopenic purpura.

    abstract::Decreased von Willebrand factor (VWF)-cleaving protease activity (<5%) has been implicated in patients with congenital thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (Upshaw-Schulman syndrome) and associated with mutations within the ADAMTS13 gene. In this report, we describe longitudinal studies in a p...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20221

    authors: Snider CE,Moore JC,Warkentin TE,Finch CN,Hayward CP,Kelton JG

    更新日期:2004-12-01 00:00:00

  • Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients.

    abstract::Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population-based cohort of newly diagnosed CLL (n = 265) and in relation to other prognostic markers. Short telomer...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ajh.23466

    authors: Mansouri L,Grabowski P,Degerman S,Svenson U,Gunnarsson R,Cahill N,Smedby KE,Geisler C,Juliusson G,Roos G,Rosenquist R

    更新日期:2013-08-01 00:00:00

  • Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway.

    abstract::Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events. However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199804)57:4<277::aid-ajh2>

    authors: Cortelazzo S,Marchetti M,Orlando E,Falanga A,Barbui T,Buchanan MR

    更新日期:1998-04-01 00:00:00

  • Treatment of immune thrombocytopenia associated with interferon therapy of hepatitis C with the anti-CD20 monoclonal antibody, rituximab.

    abstract::This case report describes a patient with hepatitis C virus infection responding to pegylated INF/ribaviron therapy, who developed immune thrombocytopenia. The severe thrombocytopenia failed to resolve with cessation of the peg-IFN/ribaviron. Because of rising hepatitis C virus RNA levels and evidence of rising serum ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20270

    authors: Weitz IC

    更新日期:2005-02-01 00:00:00

  • Cytogenetic risk score maintains its prognostic significance in AML patients with detectable measurable residual disease undergoing transplantation in remission: On behalf of the acute leukemia working party of the European society for blood and marrow tr

    abstract::While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prog...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.25905

    authors: Nagler A,Labopin M,Canaani J,Niittyvuopio R,Socié G,Kröger N,Itäla-Remes M,Yakoub-Agha I,Labussière-Wallet H,Gallego-Hernanz MP,Deconinck E,Chevallier P,Finke J,Esteve J,Mohty M

    更新日期:2020-06-12 00:00:00

  • Philadelphia-chromosome-negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation.

    abstract::A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830180211

    authors: Kessler JF,Grogan TM,Greenberg BR

    更新日期:1985-02-01 00:00:00

  • Increased Heinz body formation and impaired erythrocyte pentose phosphate shunt function during pregnancy.

    abstract::The erythrocytes of 90 pregnant women were evaluated for the presence of in vivo or in vitro oxidant damage. The reduced glutathione (P less than 0.005) and the membrane reduced sulfhydryl (P less than 0.001) concentrations were decreased in fresh erythrocytes. Following incubation with acetylphenylhydrazine, Heinz bo...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830180204

    authors: Lachant NA,Gottlieb AJ,DiFino SM,Landaw SA,Tanaka KR

    更新日期:1985-02-01 00:00:00

  • Synthesis of the minor fetal hemoglobin Fic in colonies of erythropoietic precursors isolated from human umbilical cord blood.

    abstract::The biosynthesis of the minor hemoglobin FIc, which contains acetylated gamma chains, and the major hemoglobin Fo was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesis of Hb FIc was...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830120302

    authors: Abraham EC,Reese AL,Stallings M,Abraham A,Garbutt GJ,Huisman TH

    更新日期:1982-05-01 00:00:00

  • Protein-bound cobalamin absorption declines in the elderly.

    abstract::A modified protein-bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55-75 years compared with young adu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830390202

    authors: Scarlett JD,Read H,O'Dea K

    更新日期:1992-02-01 00:00:00

  • Evaluation of single-tube osmotic fragility as a screening test for thalassemia.

    abstract::A single-tube osmotic fragility test has been proposed for thalassemia screening with a range of different concentrations of saline having been employed. We have compared the sensitivity and specificity of 0.32%, 0.34%, and 0.36% buffered saline, and on the basis of our findings, recommend the use of 0.36% saline. Thi...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20387

    authors: Chow J,Phelan L,Bain BJ

    更新日期:2005-07-01 00:00:00

  • Coincidental occurrence of pernicious anemia and mycosis fungoides in two elderly males.

    abstract::We experienced two rare cases of pernicious anemia that presented in the course of mycosis fungoides in elderly males. Pernicious anemia has recently been reported to be caused by autoimmune gastritis that produces autoantibodies to gastric parietal cells and intrinsic factor. Immunological abnormalities in mycosis fu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199806)58:2<127::aid-ajh7>

    authors: Saitoh T,Murakami H,Hayashi K,Matsushima T,Tamura J,Karasawa M,Naruse T,Tsuchiya J

    更新日期:1998-06-01 00:00:00