Abstract:
OBJECTIVE:Prior to detecting intracranial arterial stenosis, atherosclerotic wall change or plaque with positive remodeling can be evaluated with high-resolution MRI (HRMRI). We prospectively evaluate atherosclerotic arterial wall change in patients without intracranial stenosis using HRMRI at 3.0T and correlate the atherosclerotic change, cerebrovascular risk factors, and white matter hyperintensity (WMH). METHODS:Patients were prospectively recruited for one year and underwent brain MRI, TOF-MRA and HRMRI using axial 3D T1 FSE of the intracranial arteries. After excluding patients with intracranial stenosis, two neuroradiologists graded the atherosclerotic change of the intracranial arterial wall on HRMRI and WMH using a 4-point scale. The relationship between atherosclerotic changes on HRMRI, cerebrovascular risk factors, and WMH were statistically evaluated. RESULTS:Eighty-three patients without intracranial arterial stenosis were finally included. Older age (p=0.000), hypertension (p=0.002), and hyperlipidemia (p=0.007) were associated with severe atherosclerotic change on HRMRI. On multivariate analysis, older age (OR: 0.114; 95% CI: 0.033-0.397; p=0.001) and hypertension (OR: 0.178; 95% CI: 0.049-0.651; p=0.009) were significantly associated with severe atherosclerotic change on HRMRI. The presence of moderate and severe WMH was associated with older age, hypertension, and severe atherosclerotic change on HRMRI. On multivariate analysis, atherosclerotic change on HRMRI remained the only variable significantly associated with WMH (OR: 0.086; 95% CI: 0.016-0461; p=0.004). CONCLUSION:Older age and hypertension are significantly associated with intracranial atherosclerotic change on HRMRI. Atherosclerotic change detected on HRMRI may be the strongest risk factor for WMH than any other cerebrovascular risk factor in patients without intracranial stenosis.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Kim TH,Choi JW,Roh HG,Moon WJ,Moon SG,Chun YI,Kim HYdoi
10.1016/j.clineuro.2014.08.010subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1-6eissn
0303-8467issn
1872-6968pii
S0303-8467(14)00315-1journal_volume
126pub_type
杂志文章abstract::Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosupp...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2009.10.005
更新日期:2010-02-01 00:00:00
abstract::Involvement of those cranial nerves subserving taste is common in the Guillain-Barré syndrome, yet seldom reported are disturbances of taste. This may reflect relative sparing of taste fibers, which are small thinly myelinated fibers. However, the true incidence of taste disturbances in GBS is probably underestimated ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/0303-8467(90)90012-t
更新日期:1990-01-01 00:00:00
abstract::We report a case of multiple brain abscesses (BAs) in a 67-year-old man with symptoms of progredient disorientation and amnestic aphasia. Onset of symptoms occurred one week after surgical treatment of a perianal abscess. No other source of infection was identified and the abscesses were limited to the brain. The immu...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2004.11.024
更新日期:2006-02-01 00:00:00
abstract::Meningiomas are the most common benign intracranial tumors in adults arising from the dura matter. The etiology of meningiomas is mostly unknown, although several risk factors have been described, such as ionizing radiation, head injury, hormones and genetic factors. According to WHO they are classified into 3 grades,...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.12.007
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Phrenic nerve lesion is a known complication of thoracic surgical intervention, but it is rarely described following thymectomy and lung surgery. OBJECTIVE:To review the literature on thoracic intervention and phrenic nerve lesion and to describe four new cases, in which regular neurophysiological studies...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.clineuro.2011.12.016
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Delayed facial palsy (DFP) has often been described during the recovery stage of Fisher syndrome (FS), but the implications of DFP in FS pathophysiology have not been reported previously. The aim of this study was to identify the incidence and clinical course of DFP in FS, and to determine its clinical/pathop...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2015.04.025
更新日期:2015-08-01 00:00:00
abstract::The positive results of recent clinical trials examining endovascular treatment of acute stroke were the culmination of nearly two decades of studies of endovascular stroke treatment. We systematically reviewed this body of work, evaluated the strength of evidence, and performed a meta-analysis to define the clinical ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.clineuro.2017.03.005
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:A restricted neurological deficit is not uncommon in patients with cortical lesions. However, in cheiro-oral syndrome (COS) associated with cortical involvement, the topographic disparity of the cheiral and oral representation area is hardly explained by the restricted sensorium at the homolateral mouth angl...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2005.07.007
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to explore the differences in clinical outcome between short-segment fixation (SSF; occiput-C2) and multi-segment fixation (MSF; occiput-C2, 3). METHODS:From January 2008 to January 2012, patients who underwent surgery for instability at the occipitocervical junction were incl...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2014.10.013
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Preoperative embolization has the potential to decrease intraoperative blood loss and facilitate spinal cord decompression and tumor resection. OBJECTIVE:We report our institutional experience with the embolization of hypervascular extradural spinal tumors with Onyx as well as earlier embolic agents in a se...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2013.09.033
更新日期:2013-12-01 00:00:00
abstract::Arachnoid cysts are rare lesions responsible for spinal cord compression. Five cases of congenital intraspinal arachnoid cysts are reported. Three cases of thoracic and two cases of thoracolumbar region were encountered. The clinical presentation was one of progressive spastic paraparesis. The characteristic radiologi...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(84)90188-4
更新日期:1984-01-01 00:00:00
abstract::Multiple sclerosis is no longer considered to simply be an autoimmune demyelinating disease. Axonal destruction is another central pathological feature and a contributor to the accumulating disability of disease progression. The mechanism underlying axonal pathology has not been fully clarified but does not appear to ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2004.02.017
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in resi...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2018.01.027
更新日期:2018-03-01 00:00:00
abstract::An apparently innocuous complaint such as a numb chin may be associated with malignant disease, either as heralding symptom or as a manifestation of metastasis. A series of 15 patients with numbness of the chin is presented in which a malignancy was diagnosed prior to the numbness. The numbness diminished or disappear...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/s0303-8467(05)80001-0
更新日期:1991-01-01 00:00:00
abstract::Moyamoya is the disease which involves the terminal portions of the internal carotid or origins of the middle or anterior cerebral arteries. The posterior communicating arteries are also involved, but not the vertebrals or the basilar artery. The disease occurs more commonly in females than males and it has two age pe...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(97)00073-5
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:Cranial nerve palsy (CNP) secondary to cerebrospinal fluid (CSF) diversion is less familiar to us as a result of its rarity in incidence and insidiousness in presentation. This study aims to further expound the pathophysiological mechanism, clinical presentation, diagnosis, management and prognosis of CNP. M...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2016.02.010
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Shunt obstructions may partly be caused by brain debris, which intrude into the ventricular catheter during ventricle puncture. Avoiding contact between the catheter and brain tissue, by using a peel-away sheath, should reduce the number of shunt failures caused by obstruction. To test this hypothesis, we con...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.clineuro.2011.11.020
更新日期:2012-05-01 00:00:00
abstract::Polymethyl-methacrylate (PMMA) as part of bone cement is a widely used material in the context of orthopaedic implants and also in cranioplasty. Although PMMA is characterised by excellent biocompatibility with low intrinsic toxicity and inflammatory activation, a minor portion of patients develop allergic reactions. ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.07.013
更新日期:2010-12-01 00:00:00
abstract::Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs i...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2007.10.014
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Cerebral microbleeds (CMBs) are known to be indicative of bleeding-prone microangiopathy. Little is known about the significance of CMBs in anticoagulated patients. We determined the frequency of new CMBs in ischemic stroke patients who had been receiving warfarin treatment for 2 years. METHODS:A total of 20...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2013.03.004
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The relationship between serum uric acid (SUA) and the risk of ischemic stroke (IS) has been fully elucidated in previous studies. Therefore, we further investigated the relationship between SUA levels and the risk of IS. PATIENTS AND METHODS:2195 patients at the Beijing Hospital, between February 2012 and M...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2020.105906
更新日期:2020-08-01 00:00:00
abstract::Although Gamma Knife stereotactic radiosurgery (SRS) is widely used for metastatic brain tumors, optimal patient selection and treatment strategy continue to be investigated. The aim of this study was to provide treatment results with Gamma Knife SRS and to establish prognostic factors. Of the 54 patients treated from...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(00)00117-7
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:Spinal cord stimulation has been proven highly effective in the treatment of Complex Regional Pain Syndrome (CRPS). The definitive implantation of a neurostimulator is usually preceded by a therapeutic test (trial), which has the purpose of identifying whether the patient would respond positively to neuromodu...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2018.06.014
更新日期:2018-08-01 00:00:00
abstract::Spinal pathology resulting in cerebrospinal fluid (CSF) leak and intracranial hypotension is an infrequently reported and a potentially severe cause of headaches. We present a case of cerebrospinal fluid (CSF) leak caused by a thoracic disk herniation successfully treated with two targeted epidural blood patches. Alth...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2016.02.017
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:The frequency of suboccipital injections to treat headaches has increased. The third segment of the vertebral artery is located in the suboccipital triangle and its main muscular branch, the suboccipital artery of Salmon (SAS), supplies blood to the suboccipital muscles. The purpose of this study was to radi...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2013.11.020
更新日期:2014-02-01 00:00:00
abstract::A pancerebellar syndrome of subacute progression associated with cerebellar atrophy is highly suggestive of a paraneoplastic cerebellar degeneration (PCD). We describe a 27-year-old woman with systemic lupus erythematosus (SLE) that presented with a subacute pancerebellar syndrome. Serum and CSF anti-Yo, anti-Hu and a...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(96)00013-3
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Hypertension is the most common cause of intracerebral haemorrhages (ICHs), yet the short-term impact factors associated with hypertensive intracerebral haemorrhages (HICHs) in patients who undergo different surgical treatments are still unknown. MATERIALS AND METHODS:All consecutive patients with acute HIC...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2016.08.023
更新日期:2016-11-01 00:00:00
abstract::Reversible T2 hyperintense signal abnormality in the corpus callosum, although frequently seen after diffuse brain injury, has not been well clarified. With some accumulated evidence, we report a case of diffuse brain injury in a 24-year-old man. Magnetic resonance imaging (MRI) demonstrated T2 hyperintense signals in...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(00)00079-2
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Vascular cognitive impairment associated with small vessel disease (sVCI) may manifest as both cognitive and motor dysfunctions. However, few instruments exist for systematically assessing motor symptoms in sVCI, even though many neuropsychological tests exist to evaluate cognitive function. We developed a ne...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.11.001
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Thromboembolic events, seizures, neurologic symptoms and adverse effects from corticosteroids and chemotherapies are frequent clinical complications seen in Glioblastoma (GB) patients. The exact impact these have on dismal patient outcome has not been fully elucidated. We aimed at assessing treatment associat...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2015.01.006
更新日期:2015-07-01 00:00:00