Abstract:
:Sudden death (SD) is the most dramatic event in hypertrophic cardiomyopathy (HCM), often representing the first clinical manifestation of the disease, and the first concern of the clinicians who take care of such patients. HCM is now recognized as the primary cause of SD in young persons (<35 years of age), including trained athletes. Current data in unselected HCM patient populations report an approximate 0.7% per year incidence of SD, with the total cardiovascular mortality being around 1.4% annually. This review, incorporating contemporary research findings, addresses the major aspects of SD and its prevention in HCM. The traditional risk factors and other controversial risk factors for SD or the arbitrators for that event are thoroughly analyzed and the need for the development of a unique and accurate factor for SD risk stratification is discussed. Rather than enumerating clinical studies and guidelines, challenging problems concerning all aspects of SD in HCM, are critically appraised, highlighting current speculations and recommending future directions.
journal_name
Cardiol Revjournal_title
Cardiology in reviewauthors
Efthimiadis GK,Zegkos T,Meditskou S,Hadjimiltiades Sdoi
10.1097/CRD.0000000000000017subject
Has Abstractpub_date
2014-09-01 00:00:00pages
210-6issue
5eissn
1061-5377issn
1538-4683pii
00045415-201409000-00003journal_volume
22pub_type
杂志文章,评审abstract::The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200107000-00005
更新日期:2001-07-01 00:00:00
abstract::Automatic implantable cardioverter-defibrillators (AICDs) were implanted in 378 men and 95 women, mean age 69 +/- 12 years. At 3.6-year follow up, survival was 76% in patients who had an AICD because of cardiac arrest as a result of ventricular fibrillation or ventricular tachycardia not resulting from a transient or ...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000128728.49766.3f
更新日期:2005-01-01 00:00:00
abstract::Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus ce...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000003
更新日期:2014-07-01 00:00:00
abstract::Elderly patients with valvular aortic stenosis have an increased prevalence of coronary risk factors, of coronary artery disease, and evidence of other atherosclerotic vascular diseases. Statins may reduce the progression of aortic stenosis (AS). Angina pectoris, syncope or near syncope, and congestive heart failure a...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31805f6796
更新日期:2007-09-01 00:00:00
abstract::The presence of pulmonary arterial hypertension (PAH) in pregnancy is rare and signifies a high-risk pregnancy. Although the majority of mothers have knowledge of their condition before pregnancy, approximately one-third of patients are diagnosed during pregnancy. Termination of pregnancy should be discussed, and is o...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e318275cf01
更新日期:2013-07-01 00:00:00
abstract::Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythm...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31823efde2
更新日期:2012-03-01 00:00:00
abstract::Differences in the overall mortality for acute infarction in women vs men have been appreciated for some time. Some of these differences are based on the age at the time of presentation of women compared with men. Excess mortality in women is most clear at the younger end of the age spectrum. More careful examination ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200008040-00009
更新日期:2000-07-01 00:00:00
abstract::It has been shown in rodents and newborn babies that brown adipose tissue (BAT) plays an important role in the generation of heat for maintenance of core body temperature. BAT is responsible for the process of adaptive thermogenesis, which involves heat generation in response to a drop in the environment's temperature...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31829cabff
更新日期:2013-11-01 00:00:00
abstract::Cholesterol metabolism and transport has been a major focus in cardiovascular disease risk modification over the past several decades. Hydroxymethylglutaryl-CoA reductase inhibitors (statins) have been the most commonly used agents, with the greatest benefit in reducing both the primary and secondary risks of cardiova...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000245
更新日期:2019-09-01 00:00:00
abstract::Cardiac computed tomographic angiography (CCTA) has evolved at an unprecedented pace over the past decade, during which time it has proven to be an accurate and effective tool for imaging of the heart in a growing list of clinical applications. However, the rapid growth in the use of CT imaging in general has prompted...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31821daa8f
更新日期:2011-07-01 00:00:00
abstract::Vitamin K antagonists (VKAs) such as warfarin have traditionally been the major therapeutic option for anticoagulation in clinical practice. VKAs are effective and extensively recommended for the prevention of venous and arterial thromboembolism in cardiovascular disease. Despite its effectiveness, warfarin is limited...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182503e2d
更新日期:2012-09-01 00:00:00
abstract::Cardiac rupture after a myocardial infarction is an uncommon event with devastating consequences. Although the clinical features of rupture have been described, the genetic and molecular influences on this outcome in patients are less certain. In mice, at least 17 genetic models have been developed that enhance or sup...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181bf4ab4
更新日期:2009-11-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in the United States, accounting for approximately 60% of total mortality in 2002. There is evidence that race and ethnicity is a risk factor for atherothrombotic events. Blacks have a greater risk of complications from coronary heart disease and unstable angina, wi...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31815685fa
更新日期:2008-03-01 00:00:00
abstract::Endothelin is a potent vasoconstrictor substance that also can exert proliferative, inflammatory, and fibrotic changes in blood vessels and other organs. It acts on tissues in a paracrine and autocrine fashion, with local production and regulation occurring in both endothelial and nonendothelial cells. Endothelin stim...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181aa8f4a
更新日期:2009-07-01 00:00:00
abstract::Ayurveda is derived from 2 Sanskrit words, namely, "Ayus" and "Veda," meaning life and knowledge, respectively. It literally means science of life. Ayurveda, of which yoga is an integral part, is widely practiced in India and is gaining acceptance in many countries around the world. It is a comprehensive and a holisti...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000128730.31658.36
更新日期:2004-09-01 00:00:00
abstract::Intravascular ultrasound imaging is a relatively new imaging modality that uses miniaturized ultrasound transducers, which are mounted on catheter tips and introduced into the vessel lumen to provide cross-sectional images of the vascular structure in real time. It has gained popularity rapidly among interventional ca...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-199909000-00014
更新日期:1999-09-01 00:00:00
abstract::A decision-tree analysis was used to estimate the average cost per patient using the direct thrombin inhibitor argatroban for early treatment (<48 hours after thrombocytopenia onset) compared with delayed treatment (> or =48 hours after thrombocytopenia onset) of immune-mediated heparin-induced thrombocytopenia (HIT) ...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000164011.17381.6f
更新日期:2006-01-01 00:00:00
abstract::Cryptogenic stroke (CS) accounts for 20% to 40% of ischemic strokes. CS is defined as a cortical infarct suggestive of an embolic stroke with no identifiable cardiac etiology, large vessel occlusive disease, or small vessel lacunar stroke. The likely etiologies for CS are patent foramen ovale (PFO) and paroxysmal atri...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000073
更新日期:2016-07-01 00:00:00
abstract::The field of durable left ventricular assist devices has advanced dramatically since its introduction into the clinical realm. From the first-generation pulsatile HeartMate XVE device to the second-generation continuous axial flow HeartMate-2 to the current third-generation centrifugal flow devices, the left ventricul...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000268
更新日期:2019-11-01 00:00:00
abstract::Eisenmenger syndrome is characterized by elevated pulmonary vascular resistance and right-to-left shunting of blood through a systemic to pulmonary circulation connection. Treatment requires either lung transplantation with intracardiac repair or heart-lung transplantation. There are inadequate data regarding treatmen...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000181618.29506.1e
更新日期:2005-11-01 00:00:00
abstract::As direct oral anticoagulants (DOACs) have demonstrated favorable efficacy and safety outcomes compared with vitamin K antagonists for the treatment and prevention of venous thromboembolism and the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, their role in the management...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000188
更新日期:2018-09-01 00:00:00
abstract::Care of pregnant patients with congenital heart disease requires understanding of the specific congenital defect, the nature of previous surgical correction, and the residua and sequelae. General risks and principles can be adduced in management decisions. In addition, lesion- and patient-specific details are importan...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200008030-00007
更新日期:2000-05-01 00:00:00
abstract::Severe acute respiratory coronavirus-2 (SARS-CoV-2) is responsible for one of the greatest public health challenges of our lifetime, the coronavirus disease 2019 (COVID-19) pandemic. Because of the complicated postinfection sequelae and grave consequences, the search for effective therapies has become a worldwide prio...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000337
更新日期:2020-11-01 00:00:00
abstract::There is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. Viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. Antibiotic trials have been ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200207000-00004
更新日期:2002-07-01 00:00:00
abstract::Saphenous vein graft (SVG) disease after coronary artery bypass grafting (CABG) occurs in three phases: thrombosis, intimal hyperplasia, and atherosclerosis. Within the first month, thrombosis plays a major role. From month 1 to month 12, intimal hyperplasia occurs. Beyond 12 months, atherosclerosis becomes the primar...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182736190
更新日期:2013-03-01 00:00:00
abstract::The effect of an ongoing educational program on the use of cardiovascular drugs in patients with coronary artery disease without contraindications to these drugs seen in an academic cardiology clinic was assessed in 100 patients seen during the 6-month period prior to the educational program and in 200 patients seen 9...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000131191.57664.e7
更新日期:2005-03-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes. The structural and functional abnormalities are not explained by flow-limiting coronary artery disease or loading conditions. The disease affect...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000184
更新日期:2018-05-01 00:00:00
abstract::Evacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has been recently studied as a cholesterol modifying agent to reduce cardiovascular risk and mortality in high risk cardiovascular disease patients. Evacetrapib acts to decrease lipid exchange through CETP inhibition. CETP acts to transfer chole...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000137
更新日期:2017-03-01 00:00:00
abstract::Radiation-induced heart disease (RIHD) is becoming an increasing concern for patients and clinicians alike as the use of radiation therapy for the treatment of certain malignancies increases, and patient mortality secondary to neoplasms of the thorax, in particular Hodgkin's lymphoma and breast cancer, decreases. The ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182431c23
更新日期:2012-07-01 00:00:00
abstract::The physiologic effect of the sauna in human beings has been studied extensively, but only recently have there been studies to suggest sauna can be an effective therapeutic modality for patients with cardiovascular disease, especially for those with congestive heart failure. The data reported to date have been promisi...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000124844.56479.05
更新日期:2004-11-01 00:00:00