Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors.

Abstract:

:A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were prepared by propargylation of N-heteroaryl compounds. Compound 5 was obtained from sulfanilamide and sodium nitrite followed by addition of sodium azide. The products (6 a-k) were synthesized from compounds 3 and 5. The results showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Figure 6a (IC50 = 0.52 µM for hCA I and 0.34 µM for hCA II) has the most inhibitory effect among the synthesized compounds.

authors

Balci A,Arslan M,Nixha AR,Bilen C,Ergun A,Gençer N

doi

10.3109/14756366.2014.940933

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

377-82

issue

3

eissn

1475-6366

issn

1475-6374

journal_volume

30

pub_type

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