Abstract：
PURPOSE:Since there are no proven tumor markers that reflect the course of gastric cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are commonly used alternatives. However, the degree of progression that corresponds to an increase in these markers, and the values of these markers at different cancer stages, remains unclear. MATERIALS AND METHODS:This study enrolled 1,733 gastric cancer patients who underwent surgery and whose pre-operative CEA and CA19-9 levels were known. Survival curves and mean values of the two markers were compared according to the degree of cancer progression: serosa-unexposed (SU), serosa-exposed (SE), direct invasion (DI), localized seeding (P1), and extensive seeding (P2). RESULTS:The 5-year overall survival rates at each stage differed significantly, except between DI and P1 patients (17.1% vs. 10.5%, P=0.344). The mean CEA values in SU, SE, DI, P1, and P2 patients were 5.80, 5.48, 13.36, 8.06, and 22.82, respectively. The CA19-9 values for these patients were 49.40, 38.97, 101.67, 73.77, and 98.57, respectively. The increase in CEA in P2 patients was statistically significant (P=0.002), and the increases in CA19-9 in DI and P2 patients were significant (P=0.025, 0.007, respectively). There was a fair correlation between the two markers in P2 patients (r=0.494, P<0.001). CONCLUSIONS:CA19-9 can be used to assess DI of gastric cancer into adjacent organs. Both markers are useful for predicting the presence of extensive peritoneal seeding.
journal_name
J Gastric Cancerjournal_title
Journal of gastric cancerauthors
Han ES,Lee HH,Lee JS,Song KY,Park CH,Jeon HMdoi
10.5230/jgc.2014.14.2.123subject
Has Abstractpub_date
2014-06-01 00:00:00pages
123-8issue
2eissn
2093-582Xissn
2093-5641journal_volume
14pub_type
杂志文章abstract：:We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the s...
journal_title：Journal of gastric cancer
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journal_title：Journal of gastric cancer
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journal_title：Journal of gastric cancer
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journal_title：Journal of gastric cancer
pub_type： 杂志文章
doi：10.5230/jgc.2015.15.1.29
更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of gastric cancer
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Journal of gastric cancer
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更新日期：2012-06-01 00:00:00
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journal_title：Journal of gastric cancer
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pub_type： 杂志文章,评审
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journal_title：Journal of gastric cancer
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journal_title：Journal of gastric cancer
pub_type： 杂志文章,评审
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章
doi：10.5230/jgc.2014.14.3.156
更新日期：2014-09-01 00:00:00
