Abstract:
:The macula flavae (MF), populated by vitamin A-storing stellate cells (SCs), are believed to play a fundamental role in development, maintenance and repair of the vocal fold (VF) mucosa; however, to date, they have mostly been examined in observational human cadaver studies. Here, we conducted an interspecies comparison of MF and SC phenotype, as well as vitamin A quantification and localization, in human, pig, dog, rabbit and rat VF mucosae. MF containing vitamin A-positive SCs were only identified in human and rat specimens. Pig, dog and rabbit VF mucosae contained no discernable MF, but rather exhibited preferential vitamin A localization to mucous (pig), serous (dog) or mixed (rabbit) glands. This glandular vitamin A storage corresponded to exceedingly high concentrations of retinol in pig and dog mucosae, and retinyl ester in dog mucosa. These findings have significant implications for the presumed role of the MF and SCs in VF biology, the nature of vitamin A storage within the VF mucosa, and the selection of an appropriate animal model for future experimental studies.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Toya Y,Riabroy N,Davis CR,Kishimoto Y,Tanumihardjo SA,Bless DM,Welham NVdoi
10.1111/joa.12211subject
Has Abstractpub_date
2014-09-01 00:00:00pages
298-305issue
3eissn
0021-8782issn
1469-7580journal_volume
225pub_type
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