Meta-analysis in human neuroimaging: computational modeling of large-scale databases.

abstract：:Dendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. Although little is known about their function, two disparate perspectives have arisen to describe the activity patterns inherent to these diverse tree-like structures. Dendrites are thus considered either passive ...

journal_title：Annual review of neuroscience

authors： Johnston D,Magee JC,Colbert CM,Cristie BR

更新日期：1996-01-01 00:00:00

abstract：:The generation of distinct classes of neurons at defined positions within the developing vertebrate nervous system depends on inductive signals provided by local cell groups that act as organizing centers. Genetic and embryological studies have begun to elucidate the processes that control the pattern and identity of ...

journal_title：Annual review of neuroscience

authors： Lee KJ,Jessell TM

更新日期：1999-01-01 00:00:00

abstract：:Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive activation and slowed inactivation, elimination of a subunit tha...

journal_title：Annual review of neuroscience

authors： Lester HA,Karschin A

更新日期：2000-01-01 00:00:00

abstract：:It is apparent from this and other reviews of the subject that our knowledge of vestibular function is most complete for the primary canal and otolithic afferents. Relatively little progress has been made in the understanding of receptor mechanisms and the functional importance of the efferent vestibular system. Since...

journal_title：Annual review of neuroscience

authors： Precht W

更新日期：1979-01-01 00:00:00

abstract：:Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal survival factors, neurotrophins elicit many biological effects, ranging from proliferation to synaptic modulation to axonal pathfinding. Recent data indicate that ...

journal_title：Annual review of neuroscience

authors： Segal RA

更新日期：2003-01-01 00:00:00

abstract：:Mammals can discriminate among a large number (> 10,000) of unique odorants. The most highly supported explanation for this ability is that olfactory neurons express a large number of seven transmembrane receptors that are not spatially organized at the level of the olfactory epithelium, but whose axonal projections f...

journal_title：Annual review of neuroscience

authors： Gibson AD,Garbers DL

更新日期：2000-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease, yet the underlying causative molecular mechanisms are ill defined. Numerous observations based on drug studies and mutations in genes that cause PD point to a complex set of rather subtle mitochondrial defects that may be causative. Indeed, intensive inve...

journal_title：Annual review of neuroscience

authors： Haelterman NA,Yoon WH,Sandoval H,Jaiswal M,Shulman JM,Bellen HJ

更新日期：2014-01-01 00:00:00

abstract：:Odor signals received by odorant receptors (ORs) expressed by olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) are represented as an odor map in the olfactory bulb (OB). In the mouse, there are ~1,000 different OR species, and each OSN expresses only one functional OR gene in a monoallelic manner. Fur...

journal_title：Annual review of neuroscience

authors： Mori K,Sakano H

更新日期：2011-01-01 00:00:00

abstract：:Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic i...

journal_title：Annual review of neuroscience

authors： Bear MF,Abraham WC

更新日期：1996-01-01 00:00:00

abstract：:Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative differences in complex...

journal_title：Annual review of neuroscience

authors： Wehner JM,Radcliffe RA,Bowers BJ

更新日期：2001-01-01 00:00:00

abstract：:Understanding how sensory and motor processes are temporally integrated to control behavior in the hundredths of milliseconds-to-minutes range is a fascinating problem given that the basic electrophysiological properties of neurons operate on a millisecond timescale. Single-unit recording studies in monkeys have ident...

journal_title：Annual review of neuroscience

authors： Merchant H,Harrington DL,Meck WH

更新日期：2013-07-08 00:00:00

abstract：:Supervised learning plays a key role in the operation of many biological and artificial neural networks. Analysis of the computations underlying supervised learning is facilitated by the relatively simple and uniform architecture of the cerebellum, a brain area that supports numerous motor, sensory, and cognitive func...

journal_title：Annual review of neuroscience

authors： Raymond JL,Medina JF

更新日期：2018-07-08 00:00:00

abstract：:Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of...

journal_title：Annual review of neuroscience

authors： Darnell RB

更新日期：2013-07-08 00:00:00

abstract：:Medications, psychotherapy, and other treatments are effective for many patients with psychiatric disorders. However, with currently available interventions, a substantial number of patients experience incomplete resolution of symptoms, and relapse rates are high. In the search for better treatments, increasing intere...

journal_title：Annual review of neuroscience

authors： Holtzheimer PE,Mayberg HS

更新日期：2011-01-01 00:00:00

abstract：:Neural network modeling is often concerned with stimulus-driven responses, but most of the activity in the brain is internally generated. Here, we review network models of internally generated activity, focusing on three types of network dynamics: (a) sustained responses to transient stimuli, which provide a model of ...

journal_title：Annual review of neuroscience

authors： Vogels TP,Rajan K,Abbott LF

更新日期：2005-01-01 00:00:00

abstract：:Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid ...

journal_title：Annual review of neuroscience

authors： Sala Frigerio C,De Strooper B

更新日期：2016-07-08 00:00:00

abstract：:Extensive electrophysiological experiments on Aplysia neurons have resulted in an understanding of simple behaviors in terms of the activities of a single identified neurons. Beginning with the work of Kupfermann & Kandel, neuropeptides in Aplysia have become increasingly implicated as chemical agents that control or ...

journal_title：Annual review of neuroscience

authors： Kaldany RR,Nambu JR,Scheller RH

更新日期：1985-01-01 00:00:00

abstract：:Scientists have been fascinated by the human brain for centuries, yet knowledge of the cellular and molecular events that build the human brain during embryogenesis and of how abnormalities in this process lead to neurological disease remains very superficial. In particular, the lack of experimental models for a proce...

journal_title：Annual review of neuroscience

authors： Velasco S,Paulsen B,Arlotta P

更新日期：2020-07-08 00:00:00

abstract：:Zinc is an essential catalytic or structural element of many proteins, and a signaling messenger that is released by neural activity at many central excitatory synapses. Growing evidence suggests that zinc may also be a key mediator and modulator of the neuronal death associated with transient global ischemia and sust...

journal_title：Annual review of neuroscience

authors： Choi DW,Koh JY

更新日期：1998-01-01 00:00:00

abstract：:Immunotherapeutic strategies to combat neurodegenerative disorders have galvanized the scientific community since the first dramatic successes in mouse models recreating aspects of Alzheimer disease (AD) were reported. However, initial human trials of active amyloid-beta (Abeta) vaccination were halted early because o...

journal_title：Annual review of neuroscience

authors： Brody DL,Holtzman DM

更新日期：2008-01-01 00:00:00

abstract：:The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid beta peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of beta-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified...

journal_title：Annual review of neuroscience

authors： Lee VM,Goedert M,Trojanowski JQ

更新日期：2001-01-01 00:00:00

abstract：:Muscarinic signaling affects attention, action selection, learning, and memory through multiple signaling cascades, which act at different timescales and which alter ion channels in cell type-specific manners. The effects of muscarinic signaling differ between cortical layers and between brain areas. Muscarinic signal...

journal_title：Annual review of neuroscience

authors： Thiele A

更新日期：2013-07-08 00:00:00

abstract：:A prerequisite for the maintenance of homeostasis in a living organism is fine-tuned communication between different cells. The majority of extracellular signaling molecules, such as hormones and neurotransmitters, interact with a three-protein transmembrane signaling system consisting of a receptor, a G protein, and ...

journal_title：Annual review of neuroscience

authors： Gudermann T,Schöneberg T,Schultz G

更新日期：1997-01-01 00:00:00

abstract：:Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role in cortical processing. Here, we revisit the question of how to codify their diversity based upon ...

journal_title：Annual review of neuroscience

authors： Fishell G,Kepecs A

更新日期：2020-07-08 00:00:00

abstract：:Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocyte...

journal_title：Annual review of neuroscience

authors： Kofuji P,Araque A

更新日期：2021-01-06 00:00:00

abstract：:The topographic assembly of neural circuits is dependent upon the generation of specific neuronal subtypes, each subtype displaying unique properties that direct the formation of selective connections with appropriate target cells. Studies of motor neuron development in the spinal cord have begun to elucidate the mole...

journal_title：Annual review of neuroscience

authors： Shirasaki R,Pfaff SL

更新日期：2002-01-01 00:00:00

abstract：:Magnetic fields pass through tissue undiminished and without producing harmful effects, motivating their use as a wireless, minimally invasive means to control neural activity. Here, we review mechanisms and techniques coupling magnetic fields to changes in electrochemical potentials across neuronal membranes. Biologi...

journal_title：Annual review of neuroscience

authors： Christiansen MG,Senko AW,Anikeeva P

更新日期：2019-07-08 00:00:00

abstract：:The brain, which represents 2% of body mass but consumes 20% of body energy at rest, has a limited capacity to store energy and is therefore highly dependent on oxygen and glucose supply from the blood stream. Normal functioning of neural circuits thus relies on adequate matching between metabolic needs and blood supp...

journal_title：Annual review of neuroscience

authors： Andreone BJ,Lacoste B,Gu C

更新日期：2015-07-08 00:00:00

abstract：:Neurons and synapses display a rich range of time-dependent processes. Which of these are critical to understanding specific integrative functions in the brain? Computational methods of various kinds are used to understand how systems of neurons interact to produce behavior. However, these models often assume that neu...

journal_title：Annual review of neuroscience

authors： Marder E

更新日期：1998-01-01 00:00:00

abstract：:In this review, I discuss current knowledge and outstanding questions on the neuromodulators that influence aggressive behavior of the fruit fly Drosophila melanogaster. I first present evidence that Drosophila exchange information during an agonistic interaction and choose appropriate actions based on this informatio...

journal_title：Annual review of neuroscience

authors： Asahina K

更新日期：2017-07-25 00:00:00