Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation.

Abstract:

:Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

authors

Kritas SK,Saggini A,Cerulli G,Caraffa A,Antinolfi P,Pantalone A,Frydas S,Rosati M,Tei M,Speziali A,Saggini R,Pandolfi F,Conti P

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

177-81

issue

2

eissn

0393-974X

issn

1724-6083

pii

2

journal_volume

28

pub_type

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