Immunological basis of stem cell therapy in liver diseases.

Abstract:

:Unbalanced immune cell populations or immune cell infiltration of the liver can disrupt the immune-privileged state of the liver, resulting in liver injury or fibrosis. Therefore, the treatment for liver diseases involves not only hepatic regeneration but also immunological regulation. Recent studies demonstrated that stem cells, especially mesenchymal stem cells, have the capacity for not only hepatic differentiation but also immunomodulation. In this respect, stem cell therapy could be a realistic aim for liver diseases by modulating the liver regenerative processes and down-regulating immune-mediated liver damage. In this review, we discuss in detail the importance of immune cells in liver injury and repair; the mechanism by which stem cells demonstrate an immune-tolerant phenotype that can be used for allogeneic transplantation; the effect of stem cell transplantation on immune-mediated diseases, especially liver diseases; and the mechanism by which stem cells improve the hepatic microenvironment.

authors

Cui L,Shi Y,Han Y,Fan D

doi

10.1586/1744666X.2014.930665

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1185-96

issue

9

eissn

1744-666X

issn

1744-8409

journal_volume

10

pub_type

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