Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.

Abstract:

BACKGROUND:During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated. RESULTS:The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). CONCLUSIONS:This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

journal_name

BMC Microbiol

journal_title

BMC microbiology

authors

Coppo E,Del Bono V,Ventura F,Camera M,Orengo G,Viscoli C,Marchese A

doi

10.1186/1471-2180-14-148

subject

Has Abstract

pub_date

2014-06-07 00:00:00

pages

148

issn

1471-2180

pii

1471-2180-14-148

journal_volume

14

pub_type

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