Abstract:
BACKGROUND:During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated. RESULTS:The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). CONCLUSIONS:This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Coppo E,Del Bono V,Ventura F,Camera M,Orengo G,Viscoli C,Marchese Adoi
10.1186/1471-2180-14-148subject
Has Abstractpub_date
2014-06-07 00:00:00pages
148issn
1471-2180pii
1471-2180-14-148journal_volume
14pub_type
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