Ethological analyses of the effects of naloxone and the opiate antagonist ICI 154, 129 on social interactions in male house mice.

Abstract:

:The influences of the mu blocker naloxone and the novel opioid delta receptor antagonist ICI, 154, 129 on videotaped encounters between individually-housed, male Swiss mice and anosmic male 'standard opponents' were assessed using a variety of ethological analyses. The effects of drugs were studied on individual elements and on the times allocated by subjects to broad categories of behaviour. Neither of the drugs significantly altered times allocated to broad categories of behaviour. Both doses of both compounds significantly increased the incidences of some 'fearful'/defensive postures. A more detailed analysis considered the effects of the drugs on the sequences of postures used in the resident's behaviour. This involved the generation of 'dendrograms' which provided support for the view that both naloxone and ICI 154, 129 altered the associations between behavioural elements seen in saline controls (especially at higher doses) and that the effects of these antagonists were qualitatively different.

journal_name

Behav Processes

journal_title

Behavioural processes

authors

Brain PF,Brain S,Benton D

doi

10.1016/0376-6357(85)90035-X

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

341-54

issue

4

eissn

0376-6357

issn

1872-8308

pii

0376-6357(85)90035-X

journal_volume

10

pub_type

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