Abstract:
:Ceritinib and other second-generation inhibitors have demonstrated promising anticancer activity in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Specifically, they can overcome resistance due to certain gatekeeper mutations acquired following crizotinib exposure. These agents now provide new options for the management of ALK-positive NSCLC.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Ramalingam SS,Khuri FRdoi
10.1158/2159-8290.CD-14-0410subject
Has Abstractpub_date
2014-06-01 00:00:00pages
634-6issue
6eissn
2159-8274issn
2159-8290pii
4/6/634journal_volume
4pub_type
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