Abstract:
BACKGROUND:The growth and development of the posterior silk gland and the biosynthesis of the silk core protein at the fifth larval instar stage of Bombyx mori are of paramount importance for silk production. RESULTS:Here, aided by next-generation sequencing and microarry assay, we profile 1,229 microRNAs (miRNAs), including 728 novel miRNAs and 110 miRNA/miRNA* duplexes, of the posterior silk gland at the fifth larval instar. Target gene prediction yields 14,222 unique target genes from 1,195 miRNAs. Functional categorization classifies the targets into complex pathways that include both cellular and metabolic processes, especially protein synthesis and processing. CONCLUSION:The enrichment of target genes in the ribosome-related pathway indicates that miRNAs may directly regulate translation. Our findings pave a way for further functional elucidation of these miRNAs and their targets in silk production.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Li J,Cai Y,Ye L,Wang S,Che J,You Z,Yu J,Zhong Bdoi
10.1186/1471-2164-15-410subject
Has Abstractpub_date
2014-05-29 00:00:00pages
410issn
1471-2164pii
1471-2164-15-410journal_volume
15pub_type
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